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    Method for screening therapeutic agents for disuse muscular atrophy using interaction between selected proteins and a polyubiquitin chain
    1.
    发明授权
    Method for screening therapeutic agents for disuse muscular atrophy using interaction between selected proteins and a polyubiquitin chain 失效
    使用所选蛋白质与多聚遍在蛋白链之间的相互作用来筛选治疗剂用于不服用肌肉萎缩的方法

    公开(公告)号：US07700362B2

    公开(公告)日：2010-04-20

    申请号：US10581969

    申请日：2004-12-07

    申请人： Tohru Natsume ,  Ken Watanabe

    发明人： Tohru Natsume ,  Ken Watanabe

    IPC分类号： H01L21/20

    CPC分类号： G01N33/6887 ,  A61K38/1709 ,  C07K14/4702 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14

    摘要： A method for screening therapeutic agents for disuse muscular atrophy is provided that includes the steps of interacting a selected protein with a polyubiquitin chain in the presence of a candidate therapeutic agent, and determining the effect of the candidate on the binding strength between the protein and the polyubiquitin chain. The effect may be observed by color development on a substrate when the steps are carried out by way of an enzyme-linked immunosorbent assay, or by direct observation via NMR spectroscopy, X-ray crystal analysis, electron microscopy or surface plasmon resonance.

    摘要翻译： 提供了一种用于筛选用于不服用肌肉萎缩的治疗剂的方法，其包括在候选治疗剂存在下使选择的蛋白质与多聚遍在蛋白链相互作用的步骤，以及确定候选物对蛋白质与 多聚遍在蛋白链。 当通过酶联免疫吸附测定法或通过NMR光谱，X射线晶体分析，电子显微镜或表面等离子体共振直接观察时，可以通过底物上的显色来观察该效果。

    Novel Interaction Between Proteins, and Therapeutic Agent for Disuse Muscular Atrophy or Method Associated with Disuse Muscular Atrophy Taking Advantage of Novel Interaction
    2.
    发明申请
    Novel Interaction Between Proteins, and Therapeutic Agent for Disuse Muscular Atrophy or Method Associated with Disuse Muscular Atrophy Taking Advantage of Novel Interaction 失效
    蛋白质之间的新型相互作用和用于消除肌肉萎缩的治疗剂或与消除肌肉萎缩相关的方法利用新颖的相互作用

    公开(公告)号：US20080227694A1

    公开(公告)日：2008-09-18

    申请号：US10581969

    申请日：2004-12-07

    申请人： Tohru Natsume ,  Ken Watanabe

    发明人： Tohru Natsume ,  Ken Watanabe

    IPC分类号： A61K38/00 ,  C07K14/00 ,  G01N33/00 ,  A61P21/00

    CPC分类号： G01N33/6887 ,  A61K38/1709 ,  C07K14/4702 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14

    摘要： [Problem] Providing a novel interaction between proteins.[Solution Means] It has been found that there is an interaction between proteins between proteasome and ZNF216 (or AWP1). It has also been found that there is an interaction between proteins between a polyubiquitin chain and ZNF216 (or AWP1). By utilizing this novel interaction between the proteins, a therapeutic agent for disuse muscular atrophy, and a method for screening the therapeutic agents for disuse muscular atrophy, a marker for disease diagnosis, a method for evaluating the risk of onset of the disuse muscular atrophy, etc., are provided.

    摘要翻译： [问题]提供蛋白质之间的新颖相互作用。 [解决方案]已经发现蛋白酶体和ZNF216（或AWP1）之间的蛋白质之间存在相互作用。 还发现多聚遍在蛋白链与ZNF216（或AWP1）之间的蛋白质之间存在相互作用。 通过利用蛋白质之间的这种新的相互作用，用于消除肌肉萎缩的治疗剂，以及筛选用于不服用肌肉萎缩的治疗剂的方法，疾病诊断的标记物，用于评估滥用性肌肉萎缩发生风险的方法， 等等。

    Method for producing progressive power eyeglass lens
    3.
    发明授权
    Method for producing progressive power eyeglass lens 有权
    渐进式眼镜镜片的制造方法

    公开(公告)号：US09120278B2

    公开(公告)日：2015-09-01

    申请号：US13257613

    申请日：2010-03-31

    申请人： Shinichiro Kadowaki ,  Yuji Hoshi ,  Ken Watanabe

    发明人： Shinichiro Kadowaki ,  Yuji Hoshi ,  Ken Watanabe

    IPC分类号： B29D11/00 ,  B29C39/00 ,  B29C39/26 ,  B29L11/00

    CPC分类号： B29D11/00028 ,  B29C39/006 ,  B29C39/26 ,  B29L2011/0016

    摘要： A method for producing a progressive-addition plastic lens having a prism thinning applied thereto without cutting and polishing includes: a lens molding die forming step of forming a lens molding die configured by a first molding die having a molding face for forming one optical surface, which is a progressive-addition surface, of the lens and a second molding die having a molding face for forming the other optical surface of the lens, wherein the first molding die and the second molding die are arranged so that the respective molding faces thereof face inner side; a filling step of filling a lens material liquid containing a monomer composition into the formed lens molding die; and a curing step of polymerizing and curing the filled lens material liquid so as to form the lens. The molding face of the first molding die is formed so that a normal line at a point where the molding face of the first molding die intersects with a reference axis of the first molding die is inclined in the vertical direction with respect to the reference axis of the first molding die.

    摘要翻译： 一种用于制造具有施加于其上而不进行切割和抛光的棱镜变薄的渐进式塑料透镜的方法包括：透镜成型模具形成步骤，形成由具有用于形成一个光学表面的成型面的第一成型模具构成的透镜成型模具， 所述透镜的渐进加成面和具有用于形成所述透镜的另一光学面的成形面的第二成型模具，其中，所述第一成型模具和所述第二成形模具被配置成使其各成形面面对 内侧 将含有单体组合物的透镜材料液填充到成形的透镜成型模具中的填充步骤; 以及使填充的透镜材料液体聚合和固化以形成透镜的固化步骤。 第一成型模具的成型面形成为使得第一成型模具的成型面与第一成型模具的基准轴线相交的点的法线相对于第一成型模具的基准轴线在垂直方向上倾斜 第一个成型模具。

    TRANSLATOR FOR IP NETWORKS, NETWORK SYSTEM USING THE TRANSLATOR, AND IP NETWORK COUPLING METHOD THEREFOR
    4.
    发明申请
    TRANSLATOR FOR IP NETWORKS, NETWORK SYSTEM USING THE TRANSLATOR, AND IP NETWORK COUPLING METHOD THEREFOR 有权
    用于IP网络的转换器，使用转换器的网络系统及其IP网络耦合方法

    公开(公告)号：US20110211581A1

    公开(公告)日：2011-09-01

    申请号：US13105143

    申请日：2011-05-11

    申请人： Shinichi HAMAMOTO ,  Ken Watanabe ,  Kazuaki Tsuchiya ,  Naoya Ikeda

    发明人： Shinichi HAMAMOTO ,  Ken Watanabe ,  Kazuaki Tsuchiya ,  Naoya Ikeda

    IPC分类号： H04L12/56

    CPC分类号： H04L61/251 ,  H04L29/12358 ,  H04L29/12462 ,  H04L29/12801 ,  H04L61/255 ,  H04L61/6004 ,  H04L69/08 ,  H04L69/16 ,  H04L69/167 ,  H04L69/22

    摘要： A translator for coupling a first IPv4 network and a second IPv6 network having different addressing architectures for IP addresses so as not to exhaust the IP addresses of one of the two networks, a network system using the translator, and a network coupling method. When a packet is transferred from the IPv6 network to the IPv4 network, the translator assigns any of previously prepared IPv4 addresses to an IPv6 address stored in a source storing field of the IPv6 packet. The assigned address is stored in a source storing field of an IPv4 packet. A packet translation unit assigns the foregoing IPv6 address to an IPv4 address stored in a destination storing field of the IPv4 packet, when a packet is transferred from the IPv4 network to the IPv6 network, and stores this address in a destination storing field of the IPv6 packet.

    摘要翻译： 一种用于耦合第一IPv4网络和具有用于IP地址的不同寻址架构的第二IPv6网络的翻译器，以便不排除两个网络中的一个网络的IP地址，使用该转换器的网络系统以及网络耦合方法。 当数据包从IPv6网络传输到IPv4网络时，转换器将任何先前准备的IPv4地址分配给存储在IPv6数据包的源存储字段中的IPv6地址。 分配的地址存储在IPv4数据包的源存储字段中。 分组转换单元将分组从IPv4网络传送到IPv6网络时，将上述IPv6地址分配给存储在IPv4分组的目的地存储区域中的IPv4地址，并将该地址存储在IPv6的目的地存储区域中 包。

    Translator for IP networks, network system using the translator, and IP network coupling method therefor
    5.
    发明授权
    Translator for IP networks, network system using the translator, and IP network coupling method therefor 有权
    IP网络翻译器，使用翻译器的网络系统及其IP网络耦合方法

    公开(公告)号：US07965724B2

    公开(公告)日：2011-06-21

    申请号：US12629954

    申请日：2009-12-03

    申请人： Shinichi Hamamoto ,  Ken Watanabe ,  Kazuaki Tsuchiya ,  Naoya Ikeda

    发明人： Shinichi Hamamoto ,  Ken Watanabe ,  Kazuaki Tsuchiya ,  Naoya Ikeda

    IPC分类号： H04L12/66

    CPC分类号： H04L61/251 ,  H04L29/12358 ,  H04L29/12462 ,  H04L29/12801 ,  H04L61/255 ,  H04L61/6004 ,  H04L69/08 ,  H04L69/16 ,  H04L69/167 ,  H04L69/22

    摘要： A translator for coupling a first IPv4 network and a second IPv6 network having different addressing architectures for IP addresses so as not to exhaust the IP addresses of one of the two networks, a network system using the translator, and a network coupling method. When a packet is transferred from the IPv6 network to the IPv4 network, the translator assigns any of previously prepared IPv4 addresses to an IPv6 address stored in a source storing field of the IPv6 packet. The assigned address is stored in a source storing field of an IPv4 packet. A packet translation unit assigns the foregoing IPv6 address to an IPv4 address stored in a destination storing field of the IPv4 packet, when a packet is transferred from the IPv4 network to the IPv6 network, and stores this address in a destination storing field of the IPv6 packet.

    摘要翻译： 一种用于耦合第一IPv4网络和具有用于IP地址的不同寻址架构的第二IPv6网络的翻译器，以便不排除两个网络中的一个网络的IP地址，使用该转换器的网络系统以及网络耦合方法。 当数据包从IPv6网络传输到IPv4网络时，转换器将任何先前准备的IPv4地址分配给存储在IPv6数据包的源存储字段中的IPv6地址。 分配的地址存储在IPv4数据包的源存储字段中。 分组转换单元将分组从IPv4网络传送到IPv6网络时，将上述IPv6地址分配给存储在IPv4分组的目的地存储区域中的IPv4地址，并将该地址存储在IPv6的目的地存储区域中 包。

    Translator for IP networks, network system using the translator, and IP network coupling method therefor
    7.
    发明授权
    Translator for IP networks, network system using the translator, and IP network coupling method therefor 失效
    IP网络翻译器，使用翻译器的网络系统及其IP网络耦合方法

    公开(公告)号：US07653077B2

    公开(公告)日：2010-01-26

    申请号：US11892189

    申请日：2007-08-21

    申请人： Shinichi Hamamoto ,  Ken Watanabe ,  Kazuaki Tsuchiya ,  Naoya Ikeda

    发明人： Shinichi Hamamoto ,  Ken Watanabe ,  Kazuaki Tsuchiya ,  Naoya Ikeda

    IPC分类号： H04L12/66

    CPC分类号： H04L61/251 ,  H04L29/12358 ,  H04L29/12462 ,  H04L29/12801 ,  H04L61/255 ,  H04L61/6004 ,  H04L69/08 ,  H04L69/16 ,  H04L69/167 ,  H04L69/22

    摘要： A translator for coupling a first IPv4 network and a second IPv6 network having different addressing architectures for IP addresses so as not to exhaust the IP addresses of one of the two networks, a network system using the translator, and a network coupling method. When a packet is transferred from the IPv6 network to the IPv4 network, the translator assigns any of previously prepared IPv4 addresses to an IPv6 address stored in a source storing field of the IPv6 packet. The assigned address is stored in a source storing field of an IPv4 packet. A packet translation unit assigns the foregoing IPv6 address to an IPv4 address stored in a destination storing field of the IPv4 packet, when a packet is transferred from the IPv4 network to the IPv6 network, and stores this address in a destination storing field of the IPv6 packet.

    摘要翻译： 一种用于耦合第一IPv4网络和具有用于IP地址的不同寻址架构的第二IPv6网络的翻译器，以便不排除两个网络中的一个网络的IP地址，使用该转换器的网络系统以及网络耦合方法。 当数据包从IPv6网络传输到IPv4网络时，转换器将任何先前准备的IPv4地址分配给存储在IPv6数据包的源存储字段中的IPv6地址。 分配的地址存储在IPv4数据包的源存储字段中。 分组转换单元将分组从IPv4网络传送到IPv6网络时，将上述IPv6地址分配给存储在IPv4分组的目的地存储区域中的IPv4地址，并将该地址存储在IPv6的目的地存储区域中 包。

    PACKET COMMUNICATION APPARATUS
    8.
    发明申请
    PACKET COMMUNICATION APPARATUS 有权
    分组通讯设备

    公开(公告)号：US20080056238A1

    公开(公告)日：2008-03-06

    申请号：US11675184

    申请日：2007-02-15

    申请人： Yuuki Inujima ,  Yoshitaka Sainomoto ,  Ken Watanabe

    发明人： Yuuki Inujima ,  Yoshitaka Sainomoto ,  Ken Watanabe

    IPC分类号： H04L12/66

    CPC分类号： H04L12/66

    摘要： A packet communication apparatus sends an authentication request packet received from a user terminal to an authentication server. If a packet received from the authentication server is an authentication packet for the user terminal, an authentication controller executes authentication processing of the authentication packet. If the authentication packet includes connection limit information for the user terminal, a connection limit controller sets the connection limit information to the user terminal. According to the connection limit information, the packet communication apparatus sends the packet received from the user terminal to a quarantine server disposed to quarantine the user terminal.

    摘要翻译： 分组通信装置将从用户终端接收到的认证请求分组发送给认证服务器。 如果从认证服务器接收到的分组是用户终端的认证分组，则认证控制器执行认证分组的认证处理。 如果认证包包括用户终端的连接限制信息，则连接限制控制器将连接限制信息设置到用户终端。 根据连接限制信息，分组通信装置将从用户终端接收到的分组发送到隔离用户终端的隔离服务器。

    Translator for IP networks, network system using the translator, and IP network coupling method therefor
    9.
    发明申请
    Translator for IP networks, network system using the translator, and IP network coupling method therefor 失效
    IP网络翻译器，使用翻译器的网络系统及其IP网络耦合方法

    公开(公告)号：US20080043762A1

    公开(公告)日：2008-02-21

    申请号：US11892189

    申请日：2007-08-21

    申请人： Shinichi Hamamoto ,  Ken Watanabe ,  Kazuaki Tsuchiya ,  Naoya Ikeda

    发明人： Shinichi Hamamoto ,  Ken Watanabe ,  Kazuaki Tsuchiya ,  Naoya Ikeda

    IPC分类号： H04L12/56

    CPC分类号： H04L61/251 ,  H04L29/12358 ,  H04L29/12462 ,  H04L29/12801 ,  H04L61/255 ,  H04L61/6004 ,  H04L69/08 ,  H04L69/16 ,  H04L69/167 ,  H04L69/22

    摘要： A translator for coupling a first IPv4 network and a second IPv6 network having different addressing architectures for IP addresses so as not to exhaust the IP addresses of one of the two networks, a network system using the translator, and a network coupling method. When a packet is transferred from the IPv6 network to the IPv4 network, the translator assigns any of previously prepared IPv4 addresses to an IPv6 address stored in a source storing field of the IPv6 packet. The assigned address is stored in a source storing field of an IPv4 packet. A packet translation unit assigns the foregoing IPv6 address to an IPv4 address stored in a destination storing field of the IPv4 packet, when a packet is transferred from the IPv4 network to the IPv6 network, and stores this address in a destination storing field of the IPv6 packet.

    摘要翻译： 一种用于耦合第一IPv4网络和具有用于IP地址的不同寻址架构的第二IPv6网络的翻译器，以便不排除两个网络中的一个网络的IP地址，使用该转换器的网络系统以及网络耦合方法。 当数据包从IPv6网络传输到IPv4网络时，转换器将任何先前准备的IPv4地址分配给存储在IPv6数据包的源存储字段中的IPv6地址。 分配的地址存储在IPv4数据包的源存储字段中。 分组转换单元将分组从IPv4网络传送到IPv6网络时，将上述IPv6地址分配给存储在IPv4分组的目的地存储字段中的IPv4地址，并将该地址存储在IPv6的目的地存储区域中 包。