公开(公告)号：US20230242480A1

公开(公告)日：2023-08-03

申请号：US18087881

申请日：2022-12-23

Applicant: Tokyo University of Agriculture and Technology ,  JEOL Ltd.

Inventor： Akiko Nagata ,  Yuka Mizumoto ,  Ryota Sakamoto ,  Kazuo Nagasawa ,  Masaki Takiwaki ,  Yoshikuni Kikutani ,  Koji Takahashi ,  Seketsu Fukuzawa

IPC: C07C401/00 ,  G01N30/72 ,  C07F7/18

CPC classification number: C07C401/00 ,  G01N30/72 ,  C07F7/1804 ,  G01N2030/027

Abstract: The present invention is intended to provide a compound useful to analyze a vitamin D compound. The present invention provides an alkyne compound represented by Formula (I):




where in Formula (I), A is a linear carbon chain having an alkynyl group at an end and having a vinyl group at another end; X1 is CH or 13CH; X2 is CHY, CDY, 13CHY, 13CDY, CO, 13CO, C18O, or 13C18O; m is an integer from 1 to 4; when m is 2 or more, X2s are identical or different; Y is H, D, NH2, 15NH2, OH, 18OH, SH, OR, O(CO)R, OSO3H, OSO3Na, or a sugar substituent; when Formula (I) contains two or more Ys, Ys are identical or different; R is an alcohol protective group, an alkyl group, an alkenyl group, or an aryl group; X3 is C or 13C; and at least one selected from the group consisting of X1, X2(s), and X3 is modified with a stable isotope D, 13C, 18O, or 15N.

公开(公告)号：US11932595B2

公开(公告)日：2024-03-19

申请号：US17478871

申请日：2021-09-17

Applicant: KYOTO UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY ,  TEIKYO UNIVERSITY ,  THE UNIVERSITY OF TOKYO

Inventor： Motonari Uesugi ,  Yasushi Takemoto ,  Kazuo Nagasawa ,  Atsushi Kittaka ,  Fumihiro Kawagoe ,  Hayato Nakagawa

IPC: C07C31/137 ,  A61P35/00 ,  C07C215/68 ,  C07D209/48 ,  C07D249/06 ,  C07D257/04 ,  C07D401/04 ,  C07D409/04

CPC classification number: C07C31/137 ,  A61P35/00 ,  C07C215/68 ,  C07D209/48 ,  C07D249/06 ,  C07D257/04 ,  C07D401/04 ,  C07D409/04

Abstract: Provided are vitamin D3 derivatives of formula (I), pharmaceutical compositions thereof, and pharmaceutical or medical uses thereof for treating metabolic disease, a liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

公开(公告)号：US20220081381A1

公开(公告)日：2022-03-17

申请号：US17478871

申请日：2021-09-17

Applicant: Adil Salih Wakil ,  KYOTO UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY ,  TEIKYO UNIVERSITY ,  THE UNIVERSITY OF TOKYO

Inventor： Motonari Uesugi ,  Yasushi Takemoto ,  Kazuo Nagasawa ,  Atsushi Kittaka ,  Fumihiro Kawagoe ,  Hayato Nakagawa ,  Adil Salih Wakil

IPC: C07C31/137 ,  C07D209/48 ,  C07D257/04 ,  C07C215/68 ,  C07D249/06 ,  C07D401/04 ,  C07D409/04 ,  A61P35/00

Abstract: Provided are vitamin D3 derivatives of formula (I), pharmaceutical compositions thereof, and pharmaceutical or medical uses thereof for treating metabolic disease, a liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

公开(公告)号：US20180265463A1

公开(公告)日：2018-09-20

申请号：US15539260

申请日：2015-12-24

Applicant: Kyoto University ,  National University Corporation Tokyo University of Agriculture and Technology

Inventor： Mizuki Watanabe ,  Risa Asano ,  Kazuo Nagasawa ,  Motonari Uesugi

IPC: C07C401/00 ,  C07D209/48 ,  C07D495/04 ,  A61P3/04 ,  A61P1/16 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00

CPC classification number: C07C401/00 ,  A61K31/59 ,  A61K31/593 ,  A61P1/16 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00 ,  C07C2601/14 ,  C07C2602/24 ,  C07D209/48 ,  C07D211/46 ,  C07D295/125 ,  C07D495/04

Abstract: The present invention relates to vitamin D3 derivatives of the following formula, wherein each symbol has the same meaning as defined herein, and pharmaceutical or medical use thereof for treating metabolic disease, liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.