公开(公告)号：US20230242480A1

公开(公告)日：2023-08-03

申请号：US18087881

申请日：2022-12-23

申请人： Tokyo University of Agriculture and Technology ,  JEOL Ltd.

发明人： Akiko Nagata ,  Yuka Mizumoto ,  Ryota Sakamoto ,  Kazuo Nagasawa ,  Masaki Takiwaki ,  Yoshikuni Kikutani ,  Koji Takahashi ,  Seketsu Fukuzawa

IPC分类号： C07C401/00 ,  G01N30/72 ,  C07F7/18

CPC分类号： C07C401/00 ,  G01N30/72 ,  C07F7/1804 ,  G01N2030/027

摘要： The present invention is intended to provide a compound useful to analyze a vitamin D compound. The present invention provides an alkyne compound represented by Formula (I):




where in Formula (I), A is a linear carbon chain having an alkynyl group at an end and having a vinyl group at another end; X1 is CH or 13CH; X2 is CHY, CDY, 13CHY, 13CDY, CO, 13CO, C18O, or 13C18O; m is an integer from 1 to 4; when m is 2 or more, X2s are identical or different; Y is H, D, NH2, 15NH2, OH, 18OH, SH, OR, O(CO)R, OSO3H, OSO3Na, or a sugar substituent; when Formula (I) contains two or more Ys, Ys are identical or different; R is an alcohol protective group, an alkyl group, an alkenyl group, or an aryl group; X3 is C or 13C; and at least one selected from the group consisting of X1, X2(s), and X3 is modified with a stable isotope D, 13C, 18O, or 15N.

公开(公告)号：US11927510B2

公开(公告)日：2024-03-12

申请号：US16953502

申请日：2020-11-20

申请人： JEOL Ltd.

发明人： Masaki Takiwaki ,  Seketsu Fukuzawa ,  Yoshikuni Kikutani ,  Kiyotaka Fujino ,  Kentaro Abe ,  Yoshiyuki Ito

IPC分类号： G01N1/28 ,  G01N33/74 ,  G01N33/82

CPC分类号： G01N1/28 ,  G01N33/743 ,  G01N33/82 ,  G01N2001/2893 ,  Y10T436/104165

摘要： A standard calibration solution includes water, a non-alcoholic solvent that is mixed with water, and a steroid hormone, and a content of the non-alcoholic solvent is 10% by volume or more and 50% by volume or less. The standard calibration solution is used for quantitative measurement using a mass spectrometry device.

公开(公告)号：US20240125786A1

公开(公告)日：2024-04-18

申请号：US18374781

申请日：2023-09-29

申请人： JEOL Ltd. ,  Nihon University

发明人： Yoshikuni Kikutani ,  Masaki Takiwaki ,  Hiroshi Umemura ,  Seketsu Fukuzawa

IPC分类号： G01N33/574 ,  C07D209/42 ,  G01N33/96

CPC分类号： G01N33/5743 ,  C07D209/42 ,  G01N33/96 ,  C07B2200/05

摘要： A stable isotope-labeled indole carboxylic acid compound represented by Formula (I) is provided. In Formula (I), X1 to X8 are each independently C or 13C; Y is N or 15N; M is H, Na, K, Li, CH3, or C2H5; R1 is H or D; R2 is H, CH3, 13CH3, C2H5, or 13C2H5; R3 is H, CH3, 13CH3, C2H5, or 13C2H5; R4 is H or D; and R5 is H or D.

公开(公告)号：US20210156770A1

公开(公告)日：2021-05-27

申请号：US16953502

申请日：2020-11-20

申请人： JEOL Ltd.

发明人： Masaki Takiwaki ,  Seketsu Fukuzawa ,  Yoshikuni Kikutani ,  Kiyotaka Fujino ,  Kentaro Abe ,  Yoshiyuki Ito

IPC分类号： G01N1/28

摘要： A standard calibration solution includes water, a non-alcoholic solvent that is mixed with water, and a steroid hormone, and a content of the non-alcoholic solvent is 10% by volume or more and 50% by volume or less. The standard calibration solution is used for quantitative measurement using a mass spectrometry device.