公开(公告)号：US06940625B2

公开(公告)日：2005-09-06

申请号：US10851854

申请日：2004-05-20

申请人： Tomio Endo ,  Takeshi Yamagishi ,  Katsuya Sadamori

发明人： Tomio Endo ,  Takeshi Yamagishi ,  Katsuya Sadamori

IPC分类号： G02B21/00 ,  G02B26/02

CPC分类号： G02B21/0032 ,  G02B21/0024 ,  G02B21/0044

摘要： In a pattern formation member adopted to a sectioning image observation apparatus which selectively irradiates a light from a light source to a sample, scans the sample, and acquires a light from the sample as a sectioning image, the pattern formation member comprises an irradiation section and a cutoff section, each of the irradiation section and the cutoff section is in a straight pattern, and these straight patterns are disposed alternatively.

摘要翻译： 在对选择性地将来自光源的光照射到样本的切片图像观察装置的图案形成部件中，扫描样品，并从样品获取光作为切片图像，图案形成部件包括照射部和 截止部分，每个照射部分和截断部分是直线图案，并且这些直线图案交替设置。

公开(公告)号：US06747772B2

公开(公告)日：2004-06-08

申请号：US10002102

申请日：2001-11-02

申请人： Tomio Endo ,  Takeshi Yamagishi ,  Katsuya Sadamori

发明人： Tomio Endo ,  Takeshi Yamagishi ,  Katsuya Sadamori

IPC分类号： G02B2602

CPC分类号： G02B21/0032 ,  G02B21/0024 ,  G02B21/0044

摘要： In a pattern formation member adopted to a sectioning image observation apparatus which selectively irradiates a light from a light source to a sample, scans the sample, and acquires a light from the sample as a sectioning image, the pattern formation member comprises an irradiation section and a cutoff section, each of the irradiation section and the cutoff section is in a straight pattern, and these straight patterns are disposed alternatively.

摘要翻译： 在对选择性地将来自光源的光照射到样本的切片图像观察装置的图案形成部件中，扫描样品，并从样品获取光作为切片图像，图案形成部件包括照射部和 截止部分，每个照射部分和截断部分是直线图案，并且这些直线图案交替设置。

公开(公告)号：US06426835B1

公开(公告)日：2002-07-30

申请号：US09532818

申请日：2000-03-21

申请人： Tomio Endo ,  Yukio Eda ,  Katsuya Sadamori

发明人： Tomio Endo ,  Yukio Eda ,  Katsuya Sadamori

IPC分类号： G02B2106

CPC分类号： G02B21/0044 ,  G02B21/008

摘要： In a confocal microscope, a beam of light from a light source is lead to a rotary disk by way of an optical lens and a half mirror, and made to strike specimen by way of an objective lens. The rotary disk has random pin hole pattern sections where pin holes are randomly bored through a light blocking mask, and an aperture section having an area k2 times greater than the area of the random pin hole pattern sections and allowing any light to pass therethrough. The beam of light reflected by the specimen is made to enter a CCD camera by way of the objective lens, the rotary disk, the half mirror and a condenser lens. The CCD camera is adapted to selectively pick up a composite image containing a confocal image component and a non-confocal image component of the specimen obtained through the random pin hole pattern sections and a conventional image of the specimen obtained through the aperture section. Then, a CPU carries out an arithmetic operation of subtracting the conventional image data from the composite image data by means of a difference program to produce a confocal image of the specimen.

摘要翻译： 在共聚焦显微镜中，来自光源的光束通过光学透镜和半反射镜被引导到旋转盘，并通过物镜进行拍打。 旋转盘具有随机的针孔图案部分，其中针孔通过遮光掩模而随机钻孔，并且具有开口部分，其面积比随机针孔图案部分的面积大k2倍，并允许任何光通过。 由样本反射的光束通过物镜，旋转盘，半反射镜和聚光透镜进入CCD摄像机。 CCD摄像机适于选择性地拾取包含通过随机针孔图案部分获得的样本的共聚焦图像分量和非共焦图像分量的复合图像以及通过孔部分获得的样本的常规图像。 然后，CPU通过差分程序执行从合成图像数据中减去常规图像数据的算术运算，以产生样本的共聚焦图像。

公开(公告)号：US06778323B2

公开(公告)日：2004-08-17

申请号：US10086152

申请日：2002-02-27

申请人： Tomio Endo ,  Yukio Eda ,  Katsuya Sadamori

发明人： Tomio Endo ,  Yukio Eda ,  Katsuya Sadamori

IPC分类号： G02B2100

CPC分类号： G02B21/0044 ,  G02B21/008

摘要： In a confocal microscope, a beam of light from a light source is lead to a rotary disk by way of an optical lens and a half mirror, and made to strike specimen by way of an objective lens. The rotary disk has random pin hole pattern sections where pin holes are randomly bored through a light blocking mask, and an aperture section having an area k2 times greater than the area of the random pin hole pattern sections and allowing any light to pass therethrough. The beam of light reflected by the specimen is made to enter a CCD camera by way of the objective lens, the rotary disk, the half mirror and a condenser lens. The CCD camera is adapted to selectively pick up a composite image containing a confocal image component and a non-confocal image component of the specimen obtained through the random pin hole pattern sections and a conventional image of the specimen obtained through the aperture section. Then, a CPU carries out an arithmetic operation of subtracting the conventional image data from the composite image data by means of a difference program to produce a confocal image of the specimen.

摘要翻译： 在共聚焦显微镜中，来自光源的光束通过光学透镜和半反射镜被引导到旋转盘，并通过物镜进行拍打。 旋转盘具有随机的针孔图案部分，其中针孔通过遮光掩模而被随机地钻孔，孔径部分具有比随机针孔图案部分的面积大k倍的面积，并允许任何光通过 通过。 由样本反射的光束通过物镜，旋转盘，半反射镜和聚光透镜进入CCD摄像机。 CCD摄像机适于选择性地拾取包含通过随机针孔图案部分获得的样本的共聚焦图像分量和非共焦图像分量的复合图像以及通过孔部分获得的样本的常规图像。 然后，CPU通过差分程序执行从合成图像数据中减去常规图像数据的算术运算，以产生样本的共聚焦图像。

公开(公告)号：US5351544A

公开(公告)日：1994-10-04

申请号：US793615

申请日：1991-11-18

申请人： Tomio Endo ,  Masahiro Aoki ,  Takeshi Yamagishi

发明人： Tomio Endo ,  Masahiro Aoki ,  Takeshi Yamagishi

IPC分类号： G01N29/06 ,  G01N29/04 ,  G01N29/11 ,  G01N29/12 ,  G01N29/44

CPC分类号： G01N29/4454 ,  G01N29/11 ,  G01N29/12 ,  G01N29/343 ,  G01N2291/02854 ,  G01N2291/044 ,  G01N2291/2697

摘要： A measuring apparatus using an ultrasonic wave according to the invention transmits an ultrasonic wave pulse into a specimen, receives the echo reflected by the specimen and converts it into an electric signal. The components of the electric signal that represent the wave reflected by the specimen and contain data on the state of the specimen are extracted by a gate circuit. The components obtained by the gate circuit are converted into a power spectrum by a circuit for performing a Fourier transformation. The thickness of the specimen and/or the flaking state of the specimen can be determined from this power spectrum.

摘要翻译： 使用根据本发明的超声波的测量装置将超声波脉冲发送到样本中，接收由样本反射的回波并将其转换为电信号。 表示由样本反射并包含样本状态数据的电信号的分量由门电路提取。 由门电路获得的分量通过用于执行傅里叶变换的电路被转换成功率谱。 样品的厚度和/或样品的剥离状态可以从该功率谱确定。

公开(公告)号：US06577886B1

公开(公告)日：2003-06-10

申请号：US09930416

申请日：2001-08-15

申请人： Hideyuki Takaoka ,  Uma Maheswari Rajagopalan ,  Manabu Tanifuji ,  Tomio Endo

发明人： Hideyuki Takaoka ,  Uma Maheswari Rajagopalan ,  Manabu Tanifuji ,  Tomio Endo

IPC分类号： A61B505

CPC分类号： A61B5/00 ,  A61B5/16

摘要： A living body function measurement method comprises separating a light from a low coherence light source into a signal light and a reference light, modulating a frequency of at least one of the signal light and the reference light, irradiating the signal light to an observation area of a living body sample, giving a stimulation to the living body sample from an outside of the living body sample, synthesizing the signal light via the observation area and the reference light and detecting a heterodyne interference signal, and measuring a living body function of the observation area by measuring a change in the heterodyne interference signal when the stimulation is changed.

摘要翻译： 生物体功能测量方法包括将来自低相干光源的光分离成信号光和参考光，调制信号光和参考光中的至少一个的频率，将信号光照射到 生物体样品，从生物体样品的外部对生物体样品进行刺激，经由观察区域和参考光合成信号光，并检测外差干涉信号，并测量观察的生物体功能 当刺激改变时测量外差干扰信号的变化。

公开(公告)号：US4005200A

公开(公告)日：1977-01-25

申请号：US596741

申请日：1975-07-17

申请人： Isamu Utsumi ,  Tomio Endo ,  Tadaaki Kamata ,  Masayasu Ando

发明人： Isamu Utsumi ,  Tomio Endo ,  Tadaaki Kamata ,  Masayasu Ando

IPC分类号： A61K31/565 ,  A61P13/02 ,  A61P15/00 ,  C07J31/00

CPC分类号： A61K31/565 ,  C07J31/006

摘要： A new use of dehydroepiandrosterone sulfate or its salt as a parturient canal conditioning agent is disclosed.The maturity of the parturient canal and the sensitivity of uterine musculature to oxytocin are improved resulting in normal parturition by administering to a pregnant human subject at the 37th to 39th week of pregnancy a therapeutically effective amount of dehydroepiandrosterone sulfate or its pharmaceutically acceptable salts such as the sodium salt.

摘要翻译： 公开了硫酸脱氢表雄酮或其盐作为分娩管调节剂的新用途。

公开(公告)号：US6020965A

公开(公告)日：2000-02-01

申请号：US35609

申请日：1998-03-05

申请人： Tomio Endo

发明人： Tomio Endo

IPC分类号： G02B21/00 ,  G01B11/02 ,  G01B11/30 ,  G02B21/06 ,  G02B21/14 ,  G01B9/02

CPC分类号： G01B11/026 ,  G01B11/303

摘要： A phase interference microscope, comprising a light source for emitting coherent light with a constant wavelength, an interference optical system for splitting the light emitted from the light source into two light beams, irradiating one of the split light beams onto a sample and the other split light beam onto a reference mirror, and making the light beam reflected from the sample interfere with the light beam reflected from the reference mirror, a focusing device for recognizing a position of a middle point in a phase anomaly of interference light generated in the vicinity of a focusing point as a focusing point for the sample, and moving the sample to the focusing position, and a size measurement device for measuring a size of the sample on the basis of the interference light.

摘要翻译： 一种相位干涉显微镜，包括用于发射恒定波长的相干光的光源，用于将从光源发射的光分成两束光的干涉光学系统，将分离光束中的一个照射到样本上，而另一个分裂 使得从样本反射的光束与从参考反射镜反射的光束干涉的聚焦装置，用于识别在相邻反射镜附近产生的干涉光的相位异常中的中点的位置的聚焦装置， 聚焦点作为样品的聚焦点，并将样品移动到聚焦位置;以及尺寸测量装置，用于根据干涉光测量样品的尺寸。

公开(公告)号：US5834451A

公开(公告)日：1998-11-10

申请号：US776888

申请日：1997-04-15

申请人： Nakaaki Ohsawa ,  Masakazu Sugino ,  Tomio Endo

发明人： Nakaaki Ohsawa ,  Masakazu Sugino ,  Tomio Endo

IPC分类号： A61K9/08 ,  A61K9/48 ,  A61K31/56 ,  A61K31/565 ,  A61K31/5685 ,  A61P43/00 ,  C07J1/00

CPC分类号： A61K31/5685

摘要： A remedy for myotonic dystrophy, containing dehydroepiandrosterone sulfate or a pharmacologically acceptable salt thereof, being efficacious for myotonia, adynamia and amyotrophy, and having a high safety.

摘要翻译： PCT No.PCT / JP95 / 01561 Sec。 371日期1997年04月15日 102（e）日期1997年4月15日PCT提交1995年8月7日PCT公布。 出版物WO96 / 04917 日期1996年2月22日一种含有硫酸脱氢表雄酮硫酸盐或其药理学上可接受的盐的强直性营养不良症的治疗方法，对于肌强直，腺苷和肌萎缩有效，安全性高。

公开(公告)号：US5553499A

公开(公告)日：1996-09-10

申请号：US300064

申请日：1994-09-02

申请人： Nahoko Hisata ,  Tomio Endo

发明人： Nahoko Hisata ,  Tomio Endo

IPC分类号： G01N29/06 ,  G01N29/22 ,  G01N29/26 ,  G01S7/52 ,  G01S15/89 ,  G10K11/30 ,  G01N29/04

CPC分类号： G01S7/52033 ,  G01N29/06 ,  G01N29/22 ,  G01S15/8906 ,  G01S15/8911 ,  G10K11/30

摘要： Ultrasonic wave converged by an acoustic lens is made incident onto a sample and wave reflected from the sample is received and converted into received electric signal by a transducer. A part of this electric signal is picked up by a gate section and the signal thus picked up is applied to an attenuator where it is converted into a variable ratio of input to output. The strength of the signal thus gain-adjusted is compared with a threshold value by a comparator. Responsive to the comparison result thus obtained, the gain of the attenuator is adjusted to make the input/output ratio of the attenuator a desired value. A computer calculates the focus position of the acoustic lens from a gain curve of the attenuator changing when the acoustic lens is moved from a position, remote enough from its focus position, to the sample. Drivel signal responsive to the result thus calculated is applied to a Z-drive control section. As the result, the distance of the acoustic lens relative to the sample is adjusted to bring the acoustic lens to the focus position.

摘要翻译： 由声透镜收敛的超声波被入射到样品上，并且从样品反射的波被接收并由换能器转换成接收的电信号。 该电信号的一部分由栅极部分拾取，并且由此拾取的信号被施加到衰减器，在衰减器处被转换成输入到输出的可变比率。 因此通过比较器将由此增益调节的信号的强度与阈值进行比较。 响应于如此获得的比较结果，调节衰减器的增益以使衰减器的输入/输出比达到期望值。 计算机根据衰减器的增益曲线计算声透镜的聚焦位置，当声透镜从远离其对焦位置的位置移动到样本时，该放大曲线改变。 响应于如此计算的结果的驱动信号被施加到Z驱动控制部分。 结果，调节声透镜相对于样品的距离，使声透镜进入聚焦位置。