公开(公告)号：US20060074140A1

公开(公告)日：2006-04-06

申请号：US11235038

申请日：2005-09-26

申请人： Katsuya Sadamori ,  Yoshiaki Shiba

发明人： Katsuya Sadamori ,  Yoshiaki Shiba

IPC分类号： A61K6/083

CPC分类号： A61L27/12 ,  A61L27/38

摘要： To efficiently manufacture globular ceramic particles which can be formed uniformly in surrounding gaps when they are arbitrarily filled into a defect part of biological tissue or the like, without impairing the adhesiveness of cells. There is provided a method of manufacturing globular ceramic particles comprising; containing a predetermined amount of granular shaped ceramic particles inside a cylindrical container 5 that is arranged approximately horizontally, and rotating the cylindrical container about its axis.

摘要翻译： 为了有效地制造球状陶瓷颗粒，当它们任意填充到生物组织等的缺陷部分时，可以在周围间隙中均匀地形成，而不损害细胞的粘附性。 提供了制造球状陶瓷颗粒的方法，其包括： 在圆筒状的容器5的内部，大致水平地配置规定量的粒状陶瓷粒子，并使圆筒形容器绕其轴线旋转。

公开(公告)号：US06426835B1

公开(公告)日：2002-07-30

申请号：US09532818

申请日：2000-03-21

申请人： Tomio Endo ,  Yukio Eda ,  Katsuya Sadamori

发明人： Tomio Endo ,  Yukio Eda ,  Katsuya Sadamori

IPC分类号： G02B2106

CPC分类号： G02B21/0044 ,  G02B21/008

摘要： In a confocal microscope, a beam of light from a light source is lead to a rotary disk by way of an optical lens and a half mirror, and made to strike specimen by way of an objective lens. The rotary disk has random pin hole pattern sections where pin holes are randomly bored through a light blocking mask, and an aperture section having an area k2 times greater than the area of the random pin hole pattern sections and allowing any light to pass therethrough. The beam of light reflected by the specimen is made to enter a CCD camera by way of the objective lens, the rotary disk, the half mirror and a condenser lens. The CCD camera is adapted to selectively pick up a composite image containing a confocal image component and a non-confocal image component of the specimen obtained through the random pin hole pattern sections and a conventional image of the specimen obtained through the aperture section. Then, a CPU carries out an arithmetic operation of subtracting the conventional image data from the composite image data by means of a difference program to produce a confocal image of the specimen.

摘要翻译： 在共聚焦显微镜中，来自光源的光束通过光学透镜和半反射镜被引导到旋转盘，并通过物镜进行拍打。 旋转盘具有随机的针孔图案部分，其中针孔通过遮光掩模而随机钻孔，并且具有开口部分，其面积比随机针孔图案部分的面积大k2倍，并允许任何光通过。 由样本反射的光束通过物镜，旋转盘，半反射镜和聚光透镜进入CCD摄像机。 CCD摄像机适于选择性地拾取包含通过随机针孔图案部分获得的样本的共聚焦图像分量和非共焦图像分量的复合图像以及通过孔部分获得的样本的常规图像。 然后，CPU通过差分程序执行从合成图像数据中减去常规图像数据的算术运算，以产生样本的共聚焦图像。

公开(公告)号：US20080306607A1

公开(公告)日：2008-12-11

申请号：US12191541

申请日：2008-08-14

申请人： Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

发明人： Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

IPC分类号： A61F2/28

CPC分类号： A61L27/12 ,  A61F2/28 ,  A61F2/30771 ,  A61F2/32 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30118 ,  A61F2002/30144 ,  A61F2002/30146 ,  A61F2002/30154 ,  A61F2002/3024 ,  A61F2002/3028 ,  A61F2002/30677 ,  A61F2002/30785 ,  A61F2002/30828 ,  A61F2002/30879 ,  A61F2002/30892 ,  A61F2002/30957 ,  A61F2002/3412 ,  A61F2002/3611 ,  A61F2210/0004 ,  A61F2230/0006 ,  A61F2230/0017 ,  A61F2230/0021 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2310/00293

摘要： A bone substitute (a material for repairing biological tissues) made from β-TCP as the raw material comprises a plate-type base member on the surface of which a plurality of grooves extending in a single direction are formed and separated from each other by partition wall members having an almost uniform thickness. This material sustains a sufficient binding force after application to a biological tissue and exhibits an excellent effect of forming a biological tissue. This bone substitute (material for repairing biological tissues) having a main body provided with a plurality of grooves extending in a single direction which are separated from each other by partition wall members having an almost uniform thickness, and a biodegradable viscous member which is filled into at least one of the penetrating holes of the main body, and contains an agonistic factor capable of increasing the cell activity, can provide agonistic factors of sufficient types and amounts to a biological tissue, and can control the sustained-release dose thereof.

摘要翻译： 由β-TCP制成的骨替代物（用于修复生物组织的材料）作为原料，包括板状基材，其表面上形成有沿单个方向延伸的多个槽，并通过分隔彼此分离 壁构件具有几乎均匀的厚度。 这种材料在施用到生物组织后维持足够的结合力，并且表现出优异的形成生物组织的效果。 这种骨替代物（用于修复生物组织的材料）具有主体，该主体设置有沿单个方向延伸的多个槽，所述多个槽通过具有几乎均匀厚度的分隔壁构件彼此分离，以及可生物降解的粘性构件，其被填充 主体的穿透孔中的至少一个，并且含有能够增加细胞活性的激动因子，可以向生物组织提供足够类型和量的激动因子，并且可以控制其持续释放剂量。

公开(公告)号：US20070112434A1

公开(公告)日：2007-05-17

申请号：US10555243

申请日：2004-03-31

申请人： Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

发明人： Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

IPC分类号： A61F2/28

CPC分类号： A61L27/12 ,  A61F2/28 ,  A61F2/30771 ,  A61F2/32 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30118 ,  A61F2002/30144 ,  A61F2002/30146 ,  A61F2002/30154 ,  A61F2002/3024 ,  A61F2002/3028 ,  A61F2002/30677 ,  A61F2002/30785 ,  A61F2002/30828 ,  A61F2002/30879 ,  A61F2002/30892 ,  A61F2002/30957 ,  A61F2002/3412 ,  A61F2002/3611 ,  A61F2210/0004 ,  A61F2230/0006 ,  A61F2230/0017 ,  A61F2230/0021 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2310/00293

摘要： A bone substitute (a material for repairing biological tissues) made from β-TCP as the raw material comprises a plate-type base member on the surface of which a plurality of grooves extending in a single direction are formed and separated from each other by partition wall members having an almost uniform thickness. This material sustains a sufficient binding force after application to a biological tissue and exhibits an excellent effect of forming a biological tissue. This bone substitute (material for repairing biological tissues) having a main body provided with a plurality of grooves extending in a single direction which are separated from each other by partition wall members having an almost uniform thickness, and a biodegradable viscous member which is filled into at least one of the penetrating holes of the main body, and contains an agonistic factor capable of increasing the cell activity, can provide agonistic factors of sufficient types and amounts to a biological tissue, and can control the sustained-release dose thereof.

摘要翻译： 由β-TCP制成的骨替代物（用于修复生物组织的材料）作为原料，包括板状基材，其表面上形成有沿单个方向延伸的多个槽，并通过分隔彼此分离 壁构件具有几乎均匀的厚度。 这种材料在施用到生物组织后维持足够的结合力，并且表现出优异的形成生物组织的效果。 这种骨替代物（用于修复生物组织的材料）具有主体，该主体设置有沿单个方向延伸的多个槽，所述多个槽通过具有几乎均匀厚度的分隔壁构件彼此分离，以及可生物降解的粘性构件，其被填充 主体的穿透孔中的至少一个，并且含有能够增加细胞活性的激动因子，可以向生物组织提供足够类型和量的激动因子，并且可以控制其持续释放剂量。

公开(公告)号：US06778323B2

公开(公告)日：2004-08-17

申请号：US10086152

申请日：2002-02-27

申请人： Tomio Endo ,  Yukio Eda ,  Katsuya Sadamori

发明人： Tomio Endo ,  Yukio Eda ,  Katsuya Sadamori

IPC分类号： G02B2100

CPC分类号： G02B21/0044 ,  G02B21/008

摘要： In a confocal microscope, a beam of light from a light source is lead to a rotary disk by way of an optical lens and a half mirror, and made to strike specimen by way of an objective lens. The rotary disk has random pin hole pattern sections where pin holes are randomly bored through a light blocking mask, and an aperture section having an area k2 times greater than the area of the random pin hole pattern sections and allowing any light to pass therethrough. The beam of light reflected by the specimen is made to enter a CCD camera by way of the objective lens, the rotary disk, the half mirror and a condenser lens. The CCD camera is adapted to selectively pick up a composite image containing a confocal image component and a non-confocal image component of the specimen obtained through the random pin hole pattern sections and a conventional image of the specimen obtained through the aperture section. Then, a CPU carries out an arithmetic operation of subtracting the conventional image data from the composite image data by means of a difference program to produce a confocal image of the specimen.

摘要翻译： 在共聚焦显微镜中，来自光源的光束通过光学透镜和半反射镜被引导到旋转盘，并通过物镜进行拍打。 旋转盘具有随机的针孔图案部分，其中针孔通过遮光掩模而被随机地钻孔，孔径部分具有比随机针孔图案部分的面积大k倍的面积，并允许任何光通过 通过。 由样本反射的光束通过物镜，旋转盘，半反射镜和聚光透镜进入CCD摄像机。 CCD摄像机适于选择性地拾取包含通过随机针孔图案部分获得的样本的共聚焦图像分量和非共焦图像分量的复合图像以及通过孔部分获得的样本的常规图像。 然后，CPU通过差分程序执行从合成图像数据中减去常规图像数据的算术运算，以产生样本的共聚焦图像。

公开(公告)号：US06747772B2

公开(公告)日：2004-06-08

申请号：US10002102

申请日：2001-11-02

申请人： Tomio Endo ,  Takeshi Yamagishi ,  Katsuya Sadamori

发明人： Tomio Endo ,  Takeshi Yamagishi ,  Katsuya Sadamori

IPC分类号： G02B2602

CPC分类号： G02B21/0032 ,  G02B21/0024 ,  G02B21/0044

摘要： In a pattern formation member adopted to a sectioning image observation apparatus which selectively irradiates a light from a light source to a sample, scans the sample, and acquires a light from the sample as a sectioning image, the pattern formation member comprises an irradiation section and a cutoff section, each of the irradiation section and the cutoff section is in a straight pattern, and these straight patterns are disposed alternatively.

摘要翻译： 在对选择性地将来自光源的光照射到样本的切片图像观察装置的图案形成部件中，扫描样品，并从样品获取光作为切片图像，图案形成部件包括照射部和 截止部分，每个照射部分和截断部分是直线图案，并且这些直线图案交替设置。

公开(公告)号：US20080099948A1

公开(公告)日：2008-05-01

申请号：US10555140

申请日：2004-03-30

申请人： Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

发明人： Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

IPC分类号： B27N3/02

CPC分类号： A61L27/12 ,  A61F2/28 ,  A61F2/3094 ,  A61F2002/30154 ,  A61F2002/30224 ,  A61F2002/30785 ,  A61F2230/0021 ,  A61F2230/0069 ,  A61F2310/00293

摘要： An object is to promote the growth of adhered cells and improve adhesiveness of stem cells. A cylindrical scaffold made of a porous calcium phosphate (for example, beta-TCP) material has a form in which a plurality of through-holes extending in a single direction are separated from each other by partition wall members having an almost uniform thickness. The material for repairing biological tissues wherein each through-hole has a quadrangular shape, and each partition wall member has a plurality of concavities and a plurality of pores in the surface, and a process for producing the same are provided.

摘要翻译： 目的是促进粘附细胞的生长，提高干细胞的粘附性。 由多孔磷酸钙（例如β-TCP）材料制成的圆柱形支架具有这样的形式，其中通过具有几乎均匀厚度的分隔壁构件将单个方向上延伸的多个通孔彼此分离。 用于修复生物组织的材料，其中每个通孔具有四边形形状，并且每个分隔壁构件在表面中具有多个凹部和多个孔，并且提供其制造方法。

公开(公告)号：US06940625B2

公开(公告)日：2005-09-06

申请号：US10851854

申请日：2004-05-20

申请人： Tomio Endo ,  Takeshi Yamagishi ,  Katsuya Sadamori

发明人： Tomio Endo ,  Takeshi Yamagishi ,  Katsuya Sadamori

IPC分类号： G02B21/00 ,  G02B26/02

CPC分类号： G02B21/0032 ,  G02B21/0024 ,  G02B21/0044

摘要： In a pattern formation member adopted to a sectioning image observation apparatus which selectively irradiates a light from a light source to a sample, scans the sample, and acquires a light from the sample as a sectioning image, the pattern formation member comprises an irradiation section and a cutoff section, each of the irradiation section and the cutoff section is in a straight pattern, and these straight patterns are disposed alternatively.

摘要翻译： 在对选择性地将来自光源的光照射到样本的切片图像观察装置的图案形成部件中，扫描样品，并从样品获取光作为切片图像，图案形成部件包括照射部和 截止部分，每个照射部分和截断部分是直线图案，并且这些直线图案交替设置。