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    Microfluidic device and sample analysis method
    1.
    发明授权
    Microfluidic device and sample analysis method 有权

    公开(公告)号：US11097269B2

    公开(公告)日：2021-08-24

    申请号：US15945272

    申请日：2018-04-04

    Applicant: TOPPAN PRINTING CO., LTD.

    Inventor： Keisuke Goto ,  Yoichi Makino ,  Akihiro Hoshino

    IPC: B01L3/00 ,  G01N21/03 ,  G01N33/52 ,  B81B3/00 ,  B81B1/00 ,  G01N21/64 ,  B01L7/00

    Abstract: A microfluidic device includes: a base plate allowing an electromagnetic wave to pass therethrough and having no autofluorescence; a microwell array formed on the base plate and including a wall layer in which a plurality of through-holes are formed in a thickness direction; and a lid member disposed opposite to the base plate in a state of being separated from the wall layer, wherein microwells are formed by the base plate and the through-holes formed in the wall layer, and wherein the wall layer is formed of a material containing a colored component that absorbs an electromagnetic wave of a predetermined wavelength.

    MICROFLUIDIC DEVICES AND OBSERVATION METHODS
    2.
    发明申请
    MICROFLUIDIC DEVICES AND OBSERVATION METHODS 审中-公开

    公开(公告)号：US20180299380A1

    公开(公告)日：2018-10-18

    申请号：US16018277

    申请日：2018-06-26

    Applicant: Toppan Printing Co., Ltd.

    Inventor： Yoichi Makino ,  Keisuke Goto

    IPC: G01N21/64 ,  G01N21/05 ,  G01N35/08 ,  C12Q1/25 ,  C12Q1/68

    Abstract: A microfluidic device includes a substrate having an electromagnetic wave transmission property, a lid member facing the substrate and being separated from the substrate such that a flow channel is formed between the substrate and the lid member, a light absorption layer which is placed in the flow channel and absorbs an electromagnetic wave, and a microwell array formed on the substrate and having plural microwells that are open to the flow channel to receive a target of analysis.

    Analysis devices, analysis kits, and analysis systems
    5.
    发明授权
    Analysis devices, analysis kits, and analysis systems 有权

    公开(公告)号：US11559804B2

    公开(公告)日：2023-01-24

    申请号：US16173102

    申请日：2018-10-29

    Applicant: TOPPAN PRINTING CO., LTD.

    Inventor： Yoichi Makino ,  Akihiro Hoshino ,  Tomoko Kunitomi ,  Keisuke Goto ,  Yosuke Horiuchi

    IPC: G01N21/64 ,  B01L3/00 ,  B01L7/00

    Abstract: An analysis apparatus including a stage, an analysis device placed on the stage and including receiving sections which accommodate a sample and a reagent for biochemical reaction, and are communicated with one another through a flow path having an inlet and an outlet, a liquid introduction section which is connected to the inlet and supplies into the flow path the sample, the reagent, and an sealing liquid for sealing each of the receiving sections, and a waste liquid storage section which is connected to the outlet and stores as waste liquid an excess of the sample and the reagent and a part of the sealing liquid supplied to the flow path, an optical system which includes an objective lens, emits excitation light to the receiving sections and allows observation of fluorescence generated in the receiving sections by the excitation light, and a control unit that controls such that the sealing liquid and the excess of the sample and the reagent form an interface in the waste liquid storage section, and that the interface is formed at a distance not less than a fluorescence-obtainable distance from a bottom of the receiving sections.

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