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公开(公告)号：US20230248953A1
公开(公告)日：2023-08-10
申请号：US18135775
申请日：2023-04-18
Applicant: Kinneret Rand
Inventor： Kinneret Rand
IPC: A61M37/00
CPC classification number: A61M37/0015 , A61M2037/0053 , B81B2201/055 , B81B2201/057 , B33Y80/00
Abstract: An object of the present invention is to provide an anti-adhesive/anti-clogging and/or color marked/tinted micro-capillary tube (microtube), microneedle, or micropipette. Typically, the color/tint will be selected such that the tip of the microneedle or micropipette is in contrast (e.g., visually) to the biological material. The tint/color may be selected to contrast the stained biological material. In some aspects, the color mark comprises nanoparticles that are modified by adding a non-adhesive coating/material that minimizes protein adhesion/adsorption. The microtubes and/or micropipettes may be treated with an anti-clogging reagent and an anti-adhesive reagent to prevent or reduce clogging and adhesion of the micropipette or microneedle to biological materials. The microtubes and/or micropipettes may be formed using additive printing processes and additive manufacturing techniques or from micropipette and microneedle pullers.
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公开(公告)号：US20040156754A1
公开(公告)日：2004-08-12
申请号：US10745473
申请日：2003-12-22
Applicant: Infineon Technologies AG
Inventor： Michaela Fritz , Stephan Dertinger , Karin Fuchs , Thomas Haneder , Hans-Christian Hanke , Martin Jenkner , Volker Lehmann , Christian Paulus
IPC: B01L003/02
CPC classification number: B81C1/00087 , B01L3/0241 , B81B2201/057
Abstract: An apparatus, in which at least one pipette in the form of a through-hole with a predetermined diameter is formed in a substrate, with a rim of the through-hole projecting by a predetermined amount from an adjacent surface of the substrate.
Abstract translation: 一种装置，其中在衬底中形成具有预定直径的通孔形式的至少一个移液管，其中通孔的边缘从基板的相邻表面突出预定量。
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公开(公告)号：US11712549B2
公开(公告)日：2023-08-01
申请号：US16456695
申请日：2019-06-28
Applicant: Kinneret Rand
Inventor： Kinneret Rand
CPC classification number: A61M37/0015 , A61M2037/0053 , B33Y80/00 , B81B2201/055 , B81B2201/057
Abstract: An object of the present invention is to provide an anti-adhesive/anti-clogging and/or color marked/tinted micro-capillary tube (microtube), microneedle, or micropipette. Typically, the color/tint will be selected such that the tip of the microneedle or micropipette is in contrast (e.g., visually) to the biological material. The tint/color may be selected to contrast the stained biological material. In some aspects, the color mark comprises nanoparticles that are modified by adding a non-adhesive coating/material that minimizes protein adhesion/adsorption. The microtubes and/or micropipettes may be treated with an anti-clogging reagent and an anti-adhesive reagent to prevent or reduce clogging and adhesion of the micropipette or microneedle to biological materials. The microtubes and/or micropipettes may be formed using additive printing processes and additive manufacturing techniques or from micropipette and microneedle pullers.
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公开(公告)号：US20230211345A1
公开(公告)日：2023-07-06
申请号：US17684719
申请日：2022-03-02
Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.
Inventor： Wei LI , Baiquan LIN , Kaidi ZHANG , Yunfei BAI , Ping SU , Kerui XI , Zhenyu JIA
CPC classification number: B01L3/502784 , B81B3/0089 , B81C1/00714 , B01L2200/12 , B01L2300/161 , B01L2300/0819 , B01L2300/1805 , B01L2400/0415 , B81B2201/057 , B81B2203/0353 , B81C2201/013 , B81C2201/053 , B81C2201/0198
Abstract: A microfluidic chip and a fabrication method of the microfluidic chip are provided. The microfluidic chip includes an array substrate, and a hydrophobic layer disposed on a side of the array substrate. The hydrophobic layer includes at least one through-hole, and a through-hole of the at least one through-hole penetrates through the hydrophobic layer along a direction perpendicular to a plane of the array substrate. The microfluidic chip also includes at least one hydrophilic structure. A hydrophilic structure of the at least one hydrophilic structure is disposed in the through-hole.
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公开(公告)号：US20170247252A1
公开(公告)日：2017-08-31
申请号：US15444086
申请日：2017-02-27
Applicant: SMARTTIP BV
Inventor： Edin Sarajlic
IPC: B81C1/00
CPC classification number: B81C1/0015 , A61B5/150022 , A61B5/150282 , A61B5/150396 , A61B5/150511 , A61B5/150519 , A61B5/150984 , A61B5/15142 , A61M37/0015 , B81B2201/057 , B81B2201/12 , B81B2203/0118 , B81B2203/0353 , B81C1/00087 , B81C1/00111 , B81C1/00119 , B81C2201/0132 , B81C2201/0143 , B81C2201/0159 , B81C2201/0198 , C01B21/0687
Abstract: A method of manufacturing a plurality of through-holes in a layer of first material, for example for the manufacturing of a probe comprising a tip containing a channel. To manufacture the through-holes in a batch process, a layer of first material is deposited on a wafer comprising a plurality of pits a second layer is provided on the layer of first material, and the second layer is provided with a plurality of holes at central locations of the pits; using the second layer as a shadow mask when depositing a third layer at an angle, covering a part of the first material with said third material at the central locations, and etching the exposed parts of the first layer using the third layer as a protective layer.
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Patent Agency Ranking
6.发明授权公开(公告)号：US09086431B2
公开(公告)日：2015-07-21
申请号：US13978502
申请日：2012-01-13
Applicant: Edin Sarajlic
Inventor： Edin Sarajlic
CPC classification number: G01R3/00 , B01L3/502707 , B81B2201/057 , B81B2203/0118 , B81B2203/0338 , B81C1/00119 , B81C2201/0109 , Y10T29/49002
Abstract: The present invention relates to a method of manufacturing a probe comprising a cantilever with a conduit. According to the invention, an etchant window is provided in a layer covering an elongated sacrificial conduit core that is to form the conduit. This allows for an etching process where the elongated sacrificial conduit core is etched away before all material of a substrate is etched away, the remaining material of the substrate material making the probe stronger without being in the way during use of the probe.
Abstract translation: 本发明涉及一种制造探针的方法，该探针包括具有导管的悬臂。 根据本发明，在覆盖要形成导管的细长牺牲导管芯的层中提供蚀刻剂窗口。 这允许蚀刻工艺，其中在衬底的所有材料被蚀刻掉之前，细长的牺牲导管芯被蚀刻掉，使衬底材料的剩余材料在探针的使用期间不会妨碍探针。
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公开(公告)号：US20180221877A1
公开(公告)日：2018-08-09
申请号：US15945272
申请日：2018-04-04
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Keisuke Goto , Yoichi Makino , Akihiro Hoshino
CPC classification number: B01L3/502715 , B01L7/52 , B01L2300/046 , B01L2300/0829 , B01L2300/0877 , B01L2300/0887 , B01L2300/161 , B81B1/006 , B81B3/0083 , B81B2201/057 , B81B2201/058 , B81B2203/0338 , B81B2203/0353 , G01N21/03 , G01N21/6428 , G01N21/6452 , G01N33/52 , G01N2021/6439
Abstract: A microfluidic device includes: a base plate allowing an electromagnetic wave to pass therethrough and having no autofluorescence; a microwell array formed on the base plate and including a wall layer in which a plurality of through-holes are formed in a thickness direction; and a lid member disposed opposite to the base plate in a state of being separated from the wall layer, wherein microwells are formed by the base plate and the through-holes formed in the wall layer, and wherein the wall layer is formed of a material containing a colored component that absorbs an electromagnetic wave of a predetermined wavelength.
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公开(公告)号：US09975761B2
公开(公告)日：2018-05-22
申请号：US15444086
申请日：2017-02-27
Applicant: SMARTTIP BV
Inventor： Edin Sarajlic
CPC classification number: B81C1/0015 , A61B5/150022 , A61B5/150282 , A61B5/150396 , A61B5/150511 , A61B5/150519 , A61B5/150984 , A61B5/15142 , A61M37/0015 , B81B2201/057 , B81B2201/12 , B81B2203/0118 , B81B2203/0353 , B81C1/00087 , B81C1/00111 , B81C1/00119 , B81C2201/0132 , B81C2201/0143 , B81C2201/0159 , B81C2201/0198 , C01B21/0687
Abstract: A method of manufacturing a plurality of through-holes in a layer of first material, for example for the manufacturing of a probe comprising a tip containing a channel. To manufacture the through-holes in a batch process, a layer of first material is deposited on a wafer comprising a plurality of pits a second layer is provided on the layer of first material, and the second layer is provided with a plurality of holes at central locations of the pits; using the second layer as a shadow mask when depositing a third layer at an angle, covering a part of the first material with said third material at the central locations, and etching the exposed parts of the first layer using the third layer as a protective layer.
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公开(公告)号：US20070128755A1
公开(公告)日：2007-06-07
申请号：US11585769
申请日：2006-10-23
Applicant: Matthias Fuertsch , Stefan Finkbeiner , Christoph Schelling , Stefan Weiss , Thomas Wagner , Christian Maeurer , Ines Breibach
Inventor： Matthias Fuertsch , Stefan Finkbeiner , Christoph Schelling , Stefan Weiss , Thomas Wagner , Christian Maeurer , Ines Breibach
IPC: H01L21/00
CPC classification number: B81C1/00087 , B81B2201/057
Abstract: In the manufacture of at least one passage in a silicon wafer, in a first method step, starting from a first side of the wafer, a first recess is produced in the wafer, and in a second method step, starting from a second side of the wafer, a second recess is produced in the wafer. The first recess and the second recess are produced such that together they form a passage between the first and second sides of the silicon wafer.
Abstract translation: 在制造硅晶片中的至少一个通道的过程中，在第一方法步骤中，从晶片的第一侧开始，在晶片中产生第一凹槽，并且在第二方法步骤中，从第二方面开始， 在晶片中产生第二凹槽。 制造第一凹部和第二凹部，使得它们一起形成硅晶片的第一和第二面之间的通道。
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公开(公告)号：US07158159B2
公开(公告)日：2007-01-02
申请号：US11003067
申请日：2004-12-02
Applicant: Timothy Beerling , Marco Aimi
Inventor： Timothy Beerling , Marco Aimi
IPC: B41J2/14
CPC classification number: B01L3/0262 , B01L2200/12 , B01L2300/0819 , B01L2400/0487 , B81B1/004 , B81B2201/057 , B81B2201/058 , B81B2203/0353 , H01H11/02 , H01H2029/008 , Y10T428/24273 , Y10T428/2902
Abstract: A micro-machined nozzle includes a substrate having a hole formed on a first side that extends partially through a thickness dimension of the substrate and a nozzle orifice formed on a second opposite side that communicates with the hole. The nozzle orifice has at least a portion of its interior wall serrated. A method of fabricating a micro-machined nozzle includes the steps of etching a first side of a silicon substrate to form a hole that extends partially through a thickness dimension of the substrate and etching a second opposite side of the silicon substrate to form a serrated nozzle orifice that communicates with the hole.
Abstract translation: 微加工喷嘴包括：基板，其具有形成在第一侧上的部分地延伸穿过基板的厚度尺寸的孔;以及形成在与孔连通的第二相对侧上的喷嘴孔。 喷嘴孔具有其内壁的至少一部分锯齿状。 一种制造微加工喷嘴的方法包括以下步骤：蚀刻硅衬底的第一面以形成部分延伸穿过衬底的厚度尺寸并蚀刻硅衬底的第二相对侧以形成锯齿形喷嘴的孔 孔与孔连通。
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