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公开(公告)号:US4743677A
公开(公告)日:1988-05-10
申请号:US893267
申请日:1986-08-05
申请人: Toshiharu Noda , Nobutaka Fujii , Kaoru Morita , Masayuki Hori
发明人: Toshiharu Noda , Nobutaka Fujii , Kaoru Morita , Masayuki Hori
IPC分类号: A61K38/00 , A61K38/23 , C07K14/00 , C07K14/575 , C07K14/585 , G01N33/74 , C07K7/36
CPC分类号: C07K14/57527 , G01N33/74 , A61K38/00 , Y02P20/55
摘要: A peptide represented by the following formula: ##STR1## wherein Y means a sulfur atom or methylene group, A stands for Asp or Asn, B denotes Val or Met and C is Asn or Ser, or a salt thereof.
摘要翻译: 由下式表示的肽:其中Y表示硫原子或亚甲基,A表示Asp或Asn,B表示Val或Met,C表示Asn或Ser,或其盐 。
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公开(公告)号:US20110039786A1
公开(公告)日:2011-02-17
申请号:US12990161
申请日:2009-04-28
申请人: Nobutaka Fujii , Shinya Oishi , Kenji Tomita
发明人: Nobutaka Fujii , Shinya Oishi , Kenji Tomita
CPC分类号: C07K14/4703 , A61K38/00 , C07K7/02
摘要: The present invention provides a metastin derivative represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, or a pharmaceutical composition containing it. The metastin derivative or a salt thereof is superior in blood stability, and has a cancer metastasis suppressive action or cancer growth suppressive action.
摘要翻译: 本发明提供由式(I)表示的亚氨基衍生物:其中每个符号如说明书中所定义,或其盐或含有它的药物组合物。 所述转氨酶衍生物或其盐具有优异的血液稳定性,具有癌转移抑制作用或癌生长抑制作用。
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公开(公告)号:US20100055088A1
公开(公告)日:2010-03-04
申请号:US11915428
申请日:2006-05-21
申请人: Amnon Peled , Nobutaka Fujii
发明人: Amnon Peled , Nobutaka Fujii
IPC分类号: A61K39/395 , A61K38/10 , A61P17/02
CPC分类号: A61K38/04 , A61K38/10 , C07K16/2866 , C07K2317/76
摘要: The present invention provides novel uses for CXCR4 antagonists, including specifically peptides of the T-140 family, in the treatment of skin burns and other injuries. The invention further provides methods for increasing epithelialisation in a subject in need thereof, and for preventing or inhibiting fibrosis and excessive scar formation, using peptide inhibitors of the T-140 family as well as other CXCR4 antagonists.
摘要翻译: 本发明提供了用于治疗皮肤灼伤和其他损伤的CXCR4拮抗剂的新用途,特别是包括T-140家族的肽。 本发明进一步提供了使用T-140家族的肽抑制剂以及其它CXCR4拮抗剂来增加有需要的受试者中上皮形成以及用于预防或抑制纤维化和过度瘢痕形成的方法。
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公开(公告)号:US06800611B2
公开(公告)日:2004-10-05
申请号:US10337105
申请日:2003-01-06
申请人: Nobutaka Fujii , Ryuichiro Doi , Shinya Oishi
发明人: Nobutaka Fujii , Ryuichiro Doi , Shinya Oishi
IPC分类号: A61K3807
CPC分类号: C07K5/1016 , A61K38/00
摘要: The invention relates to metastin derivatives represented by the formula: X-AA1-AA2-AA3-AA4-Z (I), or a salt thereof, or a pro-drug thereof, which have cancer metastatis suppressing activity and cancer proliferation suppressing activity. The invention also relates to the use of these derivatives as drugs for preventing or treating cancers.
摘要翻译: 本发明涉及具有癌症转移抑制活性和癌细胞增殖抑制活性的由式X-AA1-AA2-AA3-AA4-Z(I)表示的亚铁蛋白衍生物或其盐或其前体药物。 本发明还涉及这些衍生物作为预防或治疗癌症的药物的用途。
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公开(公告)号:US09034814B2
公开(公告)日:2015-05-19
申请号:US11915428
申请日:2006-05-21
申请人: Amnon Peled , Nobutaka Fujii
发明人: Amnon Peled , Nobutaka Fujii
CPC分类号: A61K38/04 , A61K38/10 , C07K16/2866 , C07K2317/76
摘要: The present invention provides novel uses for CXCR4 antagonists, including specifically peptides of the T-140 family, in the treatment of skin burns and other injuries. The invention further provides methods for increasing epithelialization in a subject in need thereof, and for preventing or inhibiting fibrosis and excessive scar formation, using peptide inhibitors of the T-140 family as well as other CXCR4 antagonists.
摘要翻译: 本发明提供了用于治疗皮肤灼伤和其他损伤的CXCR4拮抗剂的新用途,特别是包括T-140家族的肽。 本发明进一步提供了使用T-140家族的肽抑制剂以及其它CXCR4拮抗剂来增加有需要的受试者中上皮形成以及用于预防或抑制纤维化和过度瘢痕形成的方法。
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公开(公告)号:US08772297B2
公开(公告)日:2014-07-08
申请号:US13579843
申请日:2011-02-17
申请人: Hideaki Kakeya , Akira Hattori , Yasuaki Takasu , Nobutaka Fujii , Shinya Oishi , Soichi Kojima , Mitsuko Hara
发明人: Hideaki Kakeya , Akira Hattori , Yasuaki Takasu , Nobutaka Fujii , Shinya Oishi , Soichi Kojima , Mitsuko Hara
IPC分类号: A61K31/495 , C07D295/104
CPC分类号: C07D295/104 , C07D211/28 , C07D295/18 , C07D405/12
摘要: The present invention provides a compound represented by the following formula (I) or a physiologically acceptable salt thereof, and use thereof for the prophylaxis or treatment of TGF-β-related diseases: wherein Y is a hydrogen atom and the like; R2 is and the like; R3 is —NR8—R9— and the like; R4, R5, R6 and R7 are the same or different and each is a hydrogen atom and the like; and X is and the like.
摘要翻译: 本发明提供由下式(I)表示的化合物或其生理学上可接受的盐,及其用于预防或治疗TGF-β相关疾病的用途:其中Y为氢原子等; R2是等等; R3是-NR8-R9-等; R4,R5,R6和R7相同或不同,各自为氢原子等; X等。
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公开(公告)号:US08592379B2
公开(公告)日:2013-11-26
申请号:US12990161
申请日:2009-04-28
申请人: Nobutaka Fujii , Shinya Oishi , Kenji Tomita
发明人: Nobutaka Fujii , Shinya Oishi , Kenji Tomita
IPC分类号: A61K38/06 , A61K38/07 , A61K38/00 , A61P25/28 , A61P35/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号: C07K14/4703 , A61K38/00 , C07K7/02
摘要: The present invention provides a metastin derivative represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, or a pharmaceutical composition containing it. The metastin derivative or a salt thereof is superior in blood stability, and has a cancer metastasis suppressive action or cancer growth suppressive action.
摘要翻译: 本发明提供由式(I)表示的亚氨基衍生物:其中每个符号如说明书中所定义,或其盐或含有它的药物组合物。 所述转氨酶衍生物或其盐具有优异的血液稳定性,具有癌转移抑制作用或癌生长抑制作用。
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公开(公告)号:US20090036416A1
公开(公告)日:2009-02-05
申请号:US12087160
申请日:2006-12-27
IPC分类号: A61K31/555
CPC分类号: A61K31/44 , A61K33/30 , C07D213/36 , A61K2300/00
摘要: A novel non-peptide CXCR4 antagonist has a low molecular-weight and uses various aromatic compounds, each containing a dipicolylamine-zinc complex. This CXCR4 antagonist finds use, e.g., as an anti-HIV agent, a metastasis inhibitor for a malignant tumor, and a chronic rheumatoid arthritis treatment and/or prevention agent.
摘要翻译: 新型非肽CXCR4拮抗剂具有低分子量并且使用各自含有二偶氮胺 - 锌络合物的各种芳族化合物。 该CXCR4拮抗剂用于例如抗HIV剂,恶性肿瘤的转移抑制剂和慢性类风湿性关节炎治疗和/或预防剂。
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公开(公告)号:US5571892A
公开(公告)日:1996-11-05
申请号:US856026
申请日:1992-07-01
申请人: Nobutaka Fujii , Naoki Yamamoto
发明人: Nobutaka Fujii , Naoki Yamamoto
摘要: A novel polypeptide represented by the following formula (I) (SEQ. ID NO: 1) ##STR1## or a salt thereof, and an anti-HIV agent containing the same as an effective ingredient. According to this invention, there can be provided a novel polypeptide having an antiviral activity against human immunodeficiency virus (HIV), a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing the same as an effective ingredient.
摘要翻译: PCT No.PCT / JP91 / 01201 Sec。 371日期:1992年7月1日 102(e)日期1992年7月1日PCT 1991年9月10日PCT PCT。 出版物WO92 / 04374 日期:1992年3月19日由下列通式(I)(SEQ ID NO:1)表示的新型多肽(I)t含有与有效成分相同的物质。 根据本发明,可以提供一种对人体免疫缺陷病毒(HIV)具有抗病毒活性的新型多肽,其药学上可接受的盐和含有该有效成分的抗HIV剂。
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公开(公告)号:US08435939B2
公开(公告)日:2013-05-07
申请号:US12583746
申请日:2009-08-25
申请人: Nobutaka Fujii
发明人: Nobutaka Fujii
CPC分类号: C07K7/08 , A61K38/00 , C07K14/43509
摘要: The present invention provides novel polypeptides of A1-Arg-A2-Cys-Tyr-A3-A4-X-A5-A6-Cit Cys-A7 (I) or their salts (wherein A1 is hydrogen or a residue of arginine, lysine, ornithine, citrulline, alanine, or the like; A2 is an aromatic amino acid residue; A3, A4 and A6 are each a residue of arginine, lysine, ornithine, citrulline, or alanine; A5 is a residue of tyrosine, phenylalanine, alanine, naphthylalanine, or citrulline; A7 is a lysine or arginine residue whose carboxyl group may be converted into amido; and X is a residue of D-ornithyl-proline, prolyl-D-ornithine, D-lysylproline, or the like, with the proviso that any one of A1, A3, A4, A5, A6 and A7 is a residue of alanine or the like or that X is citrulline or the like), and methods of using same in the treatment of HIV.
摘要翻译: 本发明提供了A1-Arg-A2-Cys-Tyr-A3-A4-X-A5-A6-Cit Cys-A7(I)或其盐(其中A1是氢或精氨酸,赖氨酸, 鸟氨酸,瓜氨酸,丙氨酸等; A2是芳香族氨基酸残基; A3,A4和A6分别是精氨酸,赖氨酸,鸟氨酸,瓜氨酸或丙氨酸的残基; A5是酪氨酸,苯丙氨酸,丙氨酸, 萘基丙氨酸或瓜氨酸; A7是其羧基可以转化为酰氨基的赖氨酸或精氨酸残基; X是D-鸟氨酸 - 脯氨酸,脯氨酰-D-鸟氨酸,D-赖氨酰脯氨酸等的残基,条件是 A1,A3,A4,A5,A6和A7中的任一个是丙氨酸等的残基,或者X是瓜氨酸等),以及在治疗HIV中使用它们的方法。
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