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    Method of detecting effect of controlling synoviolin activity
    1.
    发明申请
    Method of detecting effect of controlling synoviolin activity 审中-公开
    检测滑膜炎活性影响的方法

    公开(公告)号：US20070134720A1

    公开(公告)日：2007-06-14

    申请号：US10568913

    申请日：2004-08-20

    申请人： Toshihiro Nakajima ,  Tetsuya Amano ,  Lei Zhang ,  Rie Ikeda ,  Satoshi Yamasaki ,  Naoko Yagishita ,  Hiromitsu Yokohama ,  Motoji Kogushi

    发明人： Toshihiro Nakajima ,  Tetsuya Amano ,  Lei Zhang ,  Rie Ikeda ,  Satoshi Yamasaki ,  Naoko Yagishita ,  Hiromitsu Yokohama ,  Motoji Kogushi

    IPC分类号： A61K38/48 ,  G01N33/53 ,  C12Q1/37

    CPC分类号： A61K38/16 ,  A61K38/005 ,  C12Q1/25 ,  C12Q1/26 ,  G01N2333/90245 ,  G01N2500/00

    摘要： The present invention provides methods for evaluating the regulation on prolyl 4-hydroxylase activity. The present invention also provides screening methods using the evaluation methods. Furthermore, the present invention provides methods of screening for compounds that are useful for treating or preventing fibrosis or rheumatoid arthritis. The present invention relates to methods for detecting regulatory activity on the synoviolin ubiquitination of prolyl 4-hydroxylase α subunit (P4HA1). It also relates to methods of screening for compounds with regulatory effect on the ubiquitination activity of synoviolin on P4HA1 based on these methods. Compounds discovered in the screening are useful for treating and/or preventing diseases caused by abnormalities in the prolyl 4-hydroxylase activity, such as fibrosis and rheumatoid arthritis.

    摘要翻译： 本发明提供了评估脯氨酰4-羟化酶活性调节的方法。 本发明还提供了使用评价方法的筛选方法。 此外，本发明提供筛选可用于治疗或预防纤维化或类风湿性关节炎的化合物的方法。 本发明涉及检测脯氨酰4-羟化酶α亚基（P4HA1）的滑膜蛋白泛素化的调节活性的方法。 它还涉及基于这些方法筛选对P4HA1上滑膜素泛素化活性具有调节作用的化合物的方法。 在筛选中发现的化合物可用于治疗和/或预防由脯氨酰4-羟化酶活性异常引起的疾病，例如纤维化和类风湿性关节炎。

    Traffic information providing system,traffic information expression method and device
    4.
    发明申请
    Traffic information providing system,traffic information expression method and device 审中-公开
    交通信息提供系统，交通信息表达方法及装置

    公开(公告)号：US20060082472A1

    公开(公告)日：2006-04-20

    申请号：US10541042

    申请日：2003-12-26

    申请人： Shinya Adachi ,  Rie Ikeda

    发明人： Shinya Adachi ,  Rie Ikeda

    IPC分类号： G08G1/123 ,  G08G1/09 ,  G08G1/01 ,  G08G1/00

    CPC分类号： G08G1/096716 ,  G08G1/096741 ,  G08G1/096775

    摘要： The invention provides a traffic information display method which presents traffic information so as to quantatively indicate the reliability and superiority of traffic information. The invention also provides a traffic information providing system which clearly communicates an “unknown” section to the receiving party. The invention represents the state volume of traffic information by the state volume of each sampling point set by segmenting a target road and represents traffic information by using the state volume of traffic information and gray scale information which displays the reliability of the state volume in multiple levels. The user thus understands how reliable the traffic information is and properly evaluates the traffic information. The traffic information may be used to perform a high-accuracy path search and provide traffic information at a reasonable cost. The traffic information providing system of the invention includes traffic information providing apparatus for providing, as traffic information, the state volume of traffic information of each distance quantization unit set by segmenting a target road and mask bit information indicating that the state volume is valid or invalid, and traffic information utilization apparatus for reproducing a valid state volume by using the mask bit information. In the traffic information providing system, the receiving party clearly recognizes, based on the mask bit information, an “unknown” section enclosed by an ellipse:

    摘要翻译： 本发明提供一种提供交通信息的交通信息显示方法，以量化地指示交通信息的可靠性和优越性。 本发明还提供了一种向接收方清楚地传送“未知”部分的交通信息提供系统。 本发明通过分割目标道路设定的每个采样点的状态量来表示交通信息的状态量，并且通过使用交通信息的状态量和灰度级信息来表示交通信息，该灰度信息显示多级的状态量的可靠性 。 因此，用户了解交通信息的可靠性，并对交通信息进行适当评估。 交通信息可以用于执行高精度路径搜索，并以合理的成本提供交通信息。 本发明的交通信息提供系统包括交通信息提供装置，作为交通信息提供通过分割目标道路设定的每个距离量化单元的交通信息的状态量，以及表示状态量有效或无效的掩码位信息 以及用于通过使用掩码位信息再现有效状态量的交通信息利用装置。 在交通信息提供系统中，接收方基于掩码位信息清楚地识别由椭圆包围的“未知”部分：

    Traffic information providing system, a traffic information expressing method and device
    5.
    发明申请
    Traffic information providing system, a traffic information expressing method and device 审中-公开
    交通信息提供系统，交通信息表示方法和装置

    公开(公告)号：US20060064233A1

    公开(公告)日：2006-03-23

    申请号：US10542942

    申请日：2004-01-21

    申请人： Shinya Adachi ,  Rie Ikeda

    发明人： Shinya Adachi ,  Rie Ikeda

    IPC分类号： G08G1/00

    CPC分类号： G08G1/0104 ,  G08G1/096716 ,  G08G1/09675 ,  G08G1/096775

    摘要： The invention has as an object to provide a traffic information providing system capable of compressing traffic information represented at an arbitrary detail level to a data volume corresponding to a different communications environment. The traffic information providing system includes: traffic information providing apparatus including means for generating sampling data from traffic information represented by a function of distance from a reference position on a road or a function of time and means for performing discrete wavelet transform on the sampling data to convert the traffic information to scaling coefficients and wavelet coefficients; and traffic information utilization apparatus for performing inverse wavelet transform on the scaling coefficients and wavelet coefficients received from the traffic information providing apparatus to restore the traffic information. The receiving party can restore coarse or minute information within the range of the received information even in case the traffic information providing apparatus has provided scaling coefficients and wavelet coefficients without considering the communications environment and reception state.

    摘要翻译： 本发明的目的是提供一种交通信息提供系统，其能够将任意详细级别表示的交通信息压缩到与不同通信环境对应的数据量。 交通信息提供系统包括：交通信息提供装置，包括用于从道路上的基准位置的距离或时间函数表示的交通信息生成取样数据的装置，以及对所述取样数据进行离散小波变换的装置 将交通信息转换为缩放系数和小波系数; 以及用于对从交通信息提供装置接收到的缩放系数和小波系数执行逆小波变换的交通信息利用装置，以恢复交通信息。 即使在交通信息提供装置没有考虑通信环境和接收状态的情况下提供缩放系数和小波系数的情况下，接收方也可以在接收到的信息的范围内恢复粗略或微小的信息。

    Shape information encoding method and device, shape information decoding method and device and program
    6.
    发明申请
    Shape information encoding method and device, shape information decoding method and device and program 审中-公开
    形状信息编码方法和装置，形状信息解码方法及装置及程序

    公开(公告)号：US20060062482A1

    公开(公告)日：2006-03-23

    申请号：US10542965

    申请日：2004-01-21

    申请人： Shinya Adachi ,  Rie Ikeda

    发明人： Shinya Adachi ,  Rie Ikeda

    IPC分类号： G06K9/48

    CPC分类号： G06K9/00791 ,  G01C21/32 ,  G09B29/00

    摘要： A problem to be solved by the present invention is to make it possible to compress shape information with high efficiency even with such data represent a shape of a short segment of road or the like, and further reduce the data amount. The starting-end location (starting-end node P1) of a branch lane shape data (11) connected to a main lane of a road or the like is on a main lane shape data (12), and therefore, the starting-end location information of the branch lane is represented by a relative location utilizing a main lane shape data. For example, the starting-end location is represented as [shape data number of main lane to be referenced]+[number of nodes from starting end of main lane]+[deviation angle from the orientation of the main lane shape].

    摘要翻译： 本发明要解决的问题在于，即使这样的数据表示道路等的短段的形状，也能够高效地压缩形状信息，进一步减少数据量。