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    Method of detecting effect of controlling synoviolin activity
    3.
    发明申请
    Method of detecting effect of controlling synoviolin activity 审中-公开
    检测滑膜炎活性影响的方法

    公开(公告)号：US20070134720A1

    公开(公告)日：2007-06-14

    申请号：US10568913

    申请日：2004-08-20

    申请人： Toshihiro Nakajima ,  Tetsuya Amano ,  Lei Zhang ,  Rie Ikeda ,  Satoshi Yamasaki ,  Naoko Yagishita ,  Hiromitsu Yokohama ,  Motoji Kogushi

    发明人： Toshihiro Nakajima ,  Tetsuya Amano ,  Lei Zhang ,  Rie Ikeda ,  Satoshi Yamasaki ,  Naoko Yagishita ,  Hiromitsu Yokohama ,  Motoji Kogushi

    IPC分类号： A61K38/48 ,  G01N33/53 ,  C12Q1/37

    CPC分类号： A61K38/16 ,  A61K38/005 ,  C12Q1/25 ,  C12Q1/26 ,  G01N2333/90245 ,  G01N2500/00

    摘要： The present invention provides methods for evaluating the regulation on prolyl 4-hydroxylase activity. The present invention also provides screening methods using the evaluation methods. Furthermore, the present invention provides methods of screening for compounds that are useful for treating or preventing fibrosis or rheumatoid arthritis. The present invention relates to methods for detecting regulatory activity on the synoviolin ubiquitination of prolyl 4-hydroxylase α subunit (P4HA1). It also relates to methods of screening for compounds with regulatory effect on the ubiquitination activity of synoviolin on P4HA1 based on these methods. Compounds discovered in the screening are useful for treating and/or preventing diseases caused by abnormalities in the prolyl 4-hydroxylase activity, such as fibrosis and rheumatoid arthritis.

    摘要翻译： 本发明提供了评估脯氨酰4-羟化酶活性调节的方法。 本发明还提供了使用评价方法的筛选方法。 此外，本发明提供筛选可用于治疗或预防纤维化或类风湿性关节炎的化合物的方法。 本发明涉及检测脯氨酰4-羟化酶α亚基（P4HA1）的滑膜蛋白泛素化的调节活性的方法。 它还涉及基于这些方法筛选对P4HA1上滑膜素泛素化活性具有调节作用的化合物的方法。 在筛选中发现的化合物可用于治疗和/或预防由脯氨酰4-羟化酶活性异常引起的疾病，例如纤维化和类风湿性关节炎。

    Flashlight
    7.
    外观设计
    Flashlight 有权

    公开(公告)号：USD998204S1

    公开(公告)日：2023-09-05

    申请号：US29850953

    申请日：2022-08-24

    申请人： Lei Zhang

    设计人： Lei Zhang

    摘要： FIG. 1 is a front and top perspective view of a flashlight, showing my new design;
    FIG. 2 is a right side elevation view thereof;
    FIG. 3 is a left side elevation view thereof;
    FIG. 4 is a front elevation view thereof;
    FIG. 5 is a rear elevation view thereof;
    FIG. 6 is a top plan view thereof;
    FIG. 7 is a bottom plan view thereof;
    FIG. 8 is an enlarged perspective view of detail “8” identified in FIG. 1; and,
    FIG. 9 is an enlarged rear elevation view of detail “9” identified in FIG. 5.
    The dashed broken lines in the drawings illustrate portions of the article and form no part of the claimed design. The dash-dot-dash broken lines in FIGS. 1, 5, 8, and 9 are for the purpose of depicting the enlarged views and form no part of the claimed design.