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    Thermophilic collagenases, thermophilic bacteria capable of producing thermophilic collagenases, and process for producing said collagenases
    3.
    发明授权
    Thermophilic collagenases, thermophilic bacteria capable of producing thermophilic collagenases, and process for producing said collagenases 失效
    嗜热胶原酶，能够产生嗜热胶原酶的嗜热细菌，以及生产所述胶原酶的方法

    公开(公告)号：US4315988A

    公开(公告)日：1982-02-16

    申请号：US25748

    申请日：1979-03-30

    申请人： Naoto Miwa ,  Yoshiro Masuda ,  Seiichi Kawarabuki ,  Toshiyuki Sai ,  Takao Saito

    发明人： Naoto Miwa ,  Yoshiro Masuda ,  Seiichi Kawarabuki ,  Toshiyuki Sai ,  Takao Saito

    IPC分类号： C12N9/48 ,  A61K38/00 ,  C12N9/54 ,  C12N1/20

    CPC分类号： C12N9/54 ,  A61K38/00 ,  Y10S435/832

    摘要： This invention relates to a process for producing collagenase, which comprises aerobically cultivating a collagenase-producing bacterium belonging to the genus Bacillus, and recovering collagenase from the culture broth.This invention also provides a thermophilic bacterium of the genus Bacillus which has the ability to produce collagenase and which grows at a temperature of 42.degree. to 74.degree. C. and a pH of 5.0 to 9.0 and a novel thermophilic collagenase which does not substantially lose collagenase activity even when maintained for 1 hour at a temperature of 60.degree. C. in the presence of a calcium ion at a pH in the range of 6.5 to 8.5, and which has a molecular weight, determined by gel filtration, between those of cytochrome C and ovalbumin.

    摘要翻译： 本发明涉及一种生产胶原酶的方法，其包括有条不紊地培养属于芽孢杆菌属的胶原酶生产菌，并从培养液中回收胶原酶。 本发明还提供了芽孢杆菌属的嗜热细菌，其具有生产胶原酶的能力，并且在42℃至74℃的温度和5.0至9.0的pH下生长，并且基本上不损失胶原酶的新型嗜热胶原酶 即使在pH为6.5〜8.5的钙离子存在下，在60℃的温度下保持1小时，并且通过凝胶过滤测定分子量，细胞色素C 和卵清蛋白。

    METHOD OF TREATING A DISORDER ASSOCIATED WITH MTP
    4.
    发明申请
    METHOD OF TREATING A DISORDER ASSOCIATED WITH MTP 审中-公开
    治疗与MTP相关的疾病的方法

    公开(公告)号：US20120302636A1

    公开(公告)日：2012-11-29

    申请号：US13328787

    申请日：2011-12-16

    申请人： Harutoshi KON ,  Yoshiro Masuda ,  Hiromitsu Watanabe

    发明人： Harutoshi KON ,  Yoshiro Masuda ,  Hiromitsu Watanabe

    IPC分类号： A61K31/216 ,  A61P9/00 ,  A61P9/12 ,  A61P3/04 ,  A61P3/10 ,  A61P3/06 ,  A61P3/00

    CPC分类号： A61K31/216 ,  A61K31/222

    摘要： Provided is a method of treating or preventing a disorder in a subject comprising administering twice per day a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrate thereof, to a subject that has or is at risk of having a disorder selected from the group consisting of hyperlipidemia, arteriosclerosis, coronary artery diseases, metabolic syndrome, obesity, diabetes, prediabetes, and hypertension, whereupon the disorder is treated or prevented in the subject. The method optionally comprises administering a therapeutically effective amount of the compound of formula (I), or a pharmaceutically acceptable salt, solvate, or hydrate thereof, to the subject, in which the therapeutically effective amount is increased once or twice during the course of administration.

    摘要翻译： 本发明提供了治疗或预防受试者疾病的方法，其包括每天给予治疗有效量的式（I）化合物或其药学上可接受的盐，溶剂合物或水合物给具有或处于 具有选自高脂血症，动脉硬化，冠状动脉疾病，代谢综合征，肥胖症，糖尿病，糖尿病前期和高血压的疾病的风险，因此在受试者中治疗或预防疾病。 该方法任选地包括给予受试者治疗有效量的式（I）化合物或其药学上可接受的盐，溶剂化物或水合物，其中治疗有效量在给药过程中增加一次或两次 。