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公开(公告)号:US4309414A
公开(公告)日:1982-01-05
申请号:US87574
申请日:1979-10-23
申请人: Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai
发明人: Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai
CPC分类号: A61K47/38 , A61K31/405 , A61K47/18 , A61K47/32 , A61K9/0014
摘要: An antiinflammatory analgesic gelled ointment is disclosed which comprises indomethacin, a medium consisting of a glycol, alcohol and water, a gelling agent selected from cellulose and a carboxyvinyl polymer which has been neutralized with an amine, and water sufficiently enough to make up the balance. Such gelled ointment has an excellent antiinflammatory activity.
摘要翻译: 公开了一种消炎止痛凝胶软膏,其包含吲哚美辛,由二醇,醇和水组成的培养基,选自纤维素和已用胺中和的羧基乙烯基聚合物的胶凝剂,以及足够足以构成平衡的水。 这种凝胶软膏具有优异的抗炎活性。
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公开(公告)号:US5376107A
公开(公告)日:1994-12-27
申请号:US965618
申请日:1992-10-22
申请人: Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai , Kazuo Murata , Kenichi Takeuchi , Shuichi Izuchi
发明人: Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai , Kazuo Murata , Kenichi Takeuchi , Shuichi Izuchi
摘要: An electrotherapeutic device for passing a DC electric current through a living organism by applying a voltage to the living organism includes a battery with an internal resistance which is high enough so that changes in the resistance value of the living organism can be disregarded. Excessive flow of current is avoided even when the resistance of the living organism fluctuates. The device is safe, easy to handle, and inexpensive. It is particularly suited for use with iontophoresis; a technology by which drugs are administered using electricity.
摘要翻译: 用于通过向生物体施加电压使直流电流通过活体的电疗装置包括具有足够高的内阻的电池,从而可以忽略生物体的电阻值的变化。 即使生物体的电阻波动,也避免电流过大。 该设备安全,易于处理,价格便宜。 特别适用于离子电渗疗法; 使用电力管理药物的技术。
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公开(公告)号:US4525347A
公开(公告)日:1985-06-25
申请号:US468491
申请日:1983-02-22
申请人: Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai
发明人: Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai
CPC分类号: A61K31/405 , A61K47/18 , A61K47/32 , A61K47/38 , A61K9/0014
摘要: An antiinflammatory analgesic ointment comprising: (a) an antiinflammatory amount of indomethacin; (b) a medium consisting of a hydroxy compound in the range of from 15 to 85% by weight, water in the range of 30 to 55% by weight and a gelating agent being present in an amount sufficient to effect gelation of said ointment and selected from the group consisting of a cellulose compound and a carboxyvinyl polymer which has been neutralized with aqueous ammonia or an amine; (c) an adjuvant being present in the range of from 0.5 to 5% by weight and selected from the group consisting of a C.sub.1 -C.sub.5 alcohol ester of a C.sub.4 -C.sub.14 monocarboxylic acid and a C.sub.1 -C.sub.3 alcohol diester of a C.sub.4 -C.sub.10 dicarboxylic acid; and (d) water in an amount sufficient to make up the balance of the ointment, said ointment being adjusted in its pH from an acidic to slightly basic level sufficient to solubilize said indomethacin in the composition but not too basic a pH level to cause decomposition of said indomethacin.
摘要翻译: 一种抗炎止痛软膏,其包含:(a)抗炎剂量的吲哚美辛; (b)由15至85重量%的羟基化合物,30至55重量%的水和80至55重量%的水,和足以使所述软膏发生凝胶化的量的凝胶剂, 选自纤维素化合物和已经用氨水或胺中和的羧基乙烯基聚合物; (c)佐剂以0.5-5重量%的范围存在,并且选自C 4 -C 14单羧酸的C 1 -C 5醇酯和C 4 -C 10的C 1 -C 3醇二酯 二羧酸 和(d)足以构成软膏平衡的量的水,所述软膏的pH值从酸性至碱性水平调节至足以将所述吲哚美辛溶解于组合物中,但不过多碱性的pH值导致分解 的所述吲哚美辛。
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公开(公告)号:US4474798A
公开(公告)日:1984-10-02
申请号:US488587
申请日:1983-04-25
申请人: Toshio Inagi , Masayuki Inoue , Toyojiro Muramatsu
发明人: Toshio Inagi , Masayuki Inoue , Toyojiro Muramatsu
IPC分类号: A61K31/015 , A61K9/00 , A61K9/06 , A61K9/70 , A61K31/05 , A61K31/405 , A61K47/06 , A61K47/08 , A61K47/10 , A61P17/00 , A61P29/00 , A61K31/40
CPC分类号: A61K9/7076 , A61K31/405 , A61K47/08 , A61K47/10 , A61K9/0014 , Y10S514/97
摘要: A pharmaceutical preparation for endermic application is disclosed which comprises indomethacin and at least one solubilizer selected from the group consisting of a C.sub.10 terpenoid and a C.sub.10 phenol.
摘要翻译: 公开了一种用于皮肤外用药物的药物制剂,其包含吲哚美辛和至少一种选自C10萜类化合物和C10苯酚的增溶剂。
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公开(公告)号:US06465477B1
公开(公告)日:2002-10-15
申请号:US09436789
申请日:1999-11-08
申请人: Toyojiro Muramatsu , Katsumi Mashita , Yasuo Shinoda , Hironori Sassa , Hiroyuki Kawashima , Yoshio Tanizawa , Hideatsu Takeuchi
发明人: Toyojiro Muramatsu , Katsumi Mashita , Yasuo Shinoda , Hironori Sassa , Hiroyuki Kawashima , Yoshio Tanizawa , Hideatsu Takeuchi
IPC分类号: A61K31435
CPC分类号: A61K31/44 , A61K31/19 , A61K31/435 , Y10S514/97
摘要: Disclosed is a pharmaceutical composition comprising (E)-3,5-dihydroxy-7-[4′-4″-fluorophenyl-2′-cyclopropyl-quinolin-3′-yl]-6-heptenoic acid, or its salt or ester, of which the aqueous solution or dispersion has pH of from 6.8 to 8. The composition has good time-dependent stability and has no change in its outward appearance even after having been stored long.
摘要翻译: 公开了一种药物组合物,其包含(E)-3,5-二羟基-7- [4'-4“ - 氟苯基-2'-环丙基 - 喹啉-3'-基] -6-庚烯酸或其盐或 酯,其水溶液或分散体的pH为6.8至8.该组合物具有良好的时间依赖性稳定性,即使在长时间储存后也不会改变其外观。
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公开(公告)号:US4844898A
公开(公告)日:1989-07-04
申请号:US81150
申请日:1987-08-04
申请人: Seiichi Komori , Toyojiro Muramatsu
发明人: Seiichi Komori , Toyojiro Muramatsu
IPC分类号: A61K33/18
CPC分类号: A61K33/18
摘要: A wound-healing preparation is composed of 50-90 wt. % of a sugar, 0.5-10 wt. % of povidone-iodine, and 1-20 wt. % of water. A buffer is also contained in an amount sufficient to adjust the pH of the preparation to 3.5-6. Preferably, the preparation may additionally contain 0.1-5 wt. % of an agent for imparting an appropriate consistency and stability, which is selected from polysaccharides and derivatives thereof.
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