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26 条记录 (耗时 0.018 秒)

    Antiinflammatory analgesic gelled ointment
    2.
    发明授权
    Antiinflammatory analgesic gelled ointment 失效
    抗炎镇痛凝胶软膏

    公开(公告)号：US4525347A

    公开(公告)日：1985-06-25

    申请号：US468491

    申请日：1983-02-22

    申请人： Toshio Inagi ,  Toyojiro Muramatsu ,  Hidetaka Nagai

    发明人： Toshio Inagi ,  Toyojiro Muramatsu ,  Hidetaka Nagai

    IPC分类号： A61K31/405 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38 ,  A61K31/40 ,  A61K31/78

    CPC分类号： A61K31/405 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38 ,  A61K9/0014

    摘要： An antiinflammatory analgesic ointment comprising: (a) an antiinflammatory amount of indomethacin; (b) a medium consisting of a hydroxy compound in the range of from 15 to 85% by weight, water in the range of 30 to 55% by weight and a gelating agent being present in an amount sufficient to effect gelation of said ointment and selected from the group consisting of a cellulose compound and a carboxyvinyl polymer which has been neutralized with aqueous ammonia or an amine; (c) an adjuvant being present in the range of from 0.5 to 5% by weight and selected from the group consisting of a C.sub.1 -C.sub.5 alcohol ester of a C.sub.4 -C.sub.14 monocarboxylic acid and a C.sub.1 -C.sub.3 alcohol diester of a C.sub.4 -C.sub.10 dicarboxylic acid; and (d) water in an amount sufficient to make up the balance of the ointment, said ointment being adjusted in its pH from an acidic to slightly basic level sufficient to solubilize said indomethacin in the composition but not too basic a pH level to cause decomposition of said indomethacin.

    摘要翻译： 一种抗炎止痛软膏，其包含：（a）抗炎剂量的吲哚美辛; （b）由15至85重量％的羟基化合物，30至55重量％的水和80至55重量％的水，和足以使所述软膏发生凝胶化的量的凝胶剂， 选自纤维素化合物和已经用氨水或胺中和的羧基乙烯基聚合物; （c）佐剂以0.5-5重量％的范围存在，并且选自C 4 -C 14单羧酸的C 1 -C 5醇酯和C 4 -C 10的C 1 -C 3醇二酯 二羧酸 和（d）足以构成软膏平衡的量的水，所述软膏的pH值从酸性至碱性水平调节至足以将所述吲哚美辛溶解于组合物中，但不过多碱性的pH值导致分解 的所述吲哚美辛。

    Electrotherapeutic device
    3.
    发明授权
    Electrotherapeutic device 失效
    电疗装置

    公开(公告)号：US5376107A

    公开(公告)日：1994-12-27

    申请号：US965618

    申请日：1992-10-22

    申请人： Toshio Inagi ,  Toyojiro Muramatsu ,  Hidetaka Nagai ,  Kazuo Murata ,  Kenichi Takeuchi ,  Shuichi Izuchi

    发明人： Toshio Inagi ,  Toyojiro Muramatsu ,  Hidetaka Nagai ,  Kazuo Murata ,  Kenichi Takeuchi ,  Shuichi Izuchi

    IPC分类号： A61N1/20 ,  A61N1/30

    CPC分类号： A61N1/303 ,  A61N1/20

    摘要： An electrotherapeutic device for passing a DC electric current through a living organism by applying a voltage to the living organism includes a battery with an internal resistance which is high enough so that changes in the resistance value of the living organism can be disregarded. Excessive flow of current is avoided even when the resistance of the living organism fluctuates. The device is safe, easy to handle, and inexpensive. It is particularly suited for use with iontophoresis; a technology by which drugs are administered using electricity.

    摘要翻译： 用于通过向生物体施加电压使直流电流通过活体的电疗装置包括具有足够高的内阻的电池，从而可以忽略生物体的电阻值的变化。 即使生物体的电阻波动，也避免电流过大。 该设备安全，易于处理，价格便宜。 特别适用于离子电渗疗法; 使用电力管理药物的技术。

    Medicinal compositions adhering to stomach/duodenum
    6.
    发明授权
    Medicinal compositions adhering to stomach/duodenum 失效
    附着于胃/十二指肠的药物组合物

    公开(公告)号：US06582720B1

    公开(公告)日：2003-06-24

    申请号：US09600885

    申请日：2000-09-07

    申请人： Toshio Inagi ,  Hiroyuki Shirai ,  Norikazu Yamaguchi ,  Takeshi Nishino

    发明人： Toshio Inagi ,  Hiroyuki Shirai ,  Norikazu Yamaguchi ,  Takeshi Nishino

    IPC分类号： A61F1300

    CPC分类号： A61K9/0065 ,  A61K9/5026

    摘要： The present invention provides a gastric and/or duodenal adhesive pharmaceutical composition obtained by coating a composition, which comprises a medicament acting at the stomach and/or duodenum and one or more of ingredients selected from water insoluble polymers, polyglycerin fatty acid esters, lipids and waxes, with a polymer having adhesive capacity onto the surface of the mucosa of a digestive tract under acid conditions and separates from the mucosa of the digestive tract in neutral or alkaline conditions. This composition adheres only to the mucosa of the stomach and/or duodenum and releases the medicament over long hours so that sufficient effects are available by a small amount of the medicament.

    摘要翻译： 本发明提供通过包衣组合物获得的胃和/或十二指肠粘合剂药物组合物，所述组合物包含在胃和/或十二指肠作用的药物和一种或多种选自水不溶性聚合物，聚甘油脂肪酸酯，脂质和 蜡，具有粘合能力的聚合物在酸性条件下在消化道粘膜的表面上，并在中性或碱性条件下与消化道粘膜分离。 该组合物仅粘附到胃和/或十二指肠的粘膜上并在长时间内释放药物，以便通过少量药物获得足够的效果。

    IONTOPHORESIS PREPARATION FOR TREATING BREAST CANCER AND/OR MASTITIS
    8.
    发明申请
    IONTOPHORESIS PREPARATION FOR TREATING BREAST CANCER AND/OR MASTITIS 失效
    用于治疗乳腺癌和/或治疗的IOPOPHORESIS制剂

    公开(公告)号：US20110034859A1

    公开(公告)日：2011-02-10

    申请号：US12988047

    申请日：2009-04-17

    申请人： Kenichi Suzuki ,  Makoto Kanebako ,  Toshio Inagi

    发明人： Kenichi Suzuki ,  Makoto Kanebako ,  Toshio Inagi

    IPC分类号： A61N1/30 ,  A61K33/00

    CPC分类号： A61K45/06 ,  A61K9/0009 ,  A61K9/0041 ,  A61K31/555 ,  A61K31/675 ,  A61K33/24 ,  A61N1/044 ,  A61N1/0448 ,  A61K2300/00

    摘要： Provided is to enhance the therapeutic effect of an iontophoretic preparation for treatment of breast cancer or mastitis.An iontophoretic preparation for treatment of breast cancer and/or mastitis containing, as an active ingredient, a nonsteroidal anti-inflammatory analgesic agent and/or an anticancer agent, wherein an electrolyte is topically administered through the nipple part into the mammary gland; subsequently, a donor is applied to the nipple part; and the active ingredient is topically administered through the nipple part into the mammary gland by application of current.

    摘要翻译： 提供用于治疗乳腺癌或乳腺炎的离子电渗疗法的治疗效果。 一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法制剂，其包含作为活性成分的非甾体抗炎止痛剂和/或抗癌剂，其中电解质通过乳头部分局部施用到乳腺中; 随后，将供体施加到乳头部分; 并且活性成分通过施加电流通过乳头部分局部施用到乳腺中。

    Composition containing medicine extremely slightly soluble in water and method for preparation thereof
    10.
    发明授权
    Composition containing medicine extremely slightly soluble in water and method for preparation thereof 失效
    含有极微溶于水的药物的组合物及其制备方法

    公开(公告)号：US08101207B2

    公开(公告)日：2012-01-24

    申请号：US10551901

    申请日：2004-04-28

    申请人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Yasuo Shinoda ,  Toshio Inagi ,  Hirofumi Takeuchi

    发明人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Yasuo Shinoda ,  Toshio Inagi ,  Hirofumi Takeuchi

    IPC分类号： A61K9/20 ,  A61K47/02 ,  A61K47/04 ,  A61K31/50

    CPC分类号： A61K31/50 ,  A61K9/1611 ,  A61K9/1694 ,  A61K9/2009 ,  A61K9/2095

    摘要： A composition containing a very low water-soluble drug, which composition is produced by treating, with a supercritical or subcritical carbon dioxide fluid, a mixture containing a very low water-soluble drug and a porous material (exclusive of a porous silica material characterized in that the material has an average pore diameter of 1 to 20 nm, the total pore volume of the material that have a diameter falling within a range of ±40% of the average pore diameter account for 60% or more the volume of all the pores of the material, and, when subjected to X-ray diffractometry, the material exhibits one or more peaks at a diffraction angle (2θ) corresponding to d of 1 nm or more); and a method for producing the composition.The very-low-water-soluble-drug-containing composition of the present invention ensures improved dissolution of the very low water-soluble drug.

    摘要翻译： 含有非常低水溶性药物的组合物，该组合物通过用超临界或亚临界二氧化碳流体处理含有非常低水溶性药物和多孔材料的混合物（不包括多孔二氧化硅材料 该材料的平均孔径为1〜20nm，直径在平均孔径的±40％范围内的材料的总孔体积占所有孔的体积的60％以上 的材料，当进行X射线衍射测定时，该材料在对应于d的衍射角（2θ）为1nm以上）表现出一个以上的峰值。 以及该组合物的制造方法。 本发明的非常低水溶性药物的组合物确保极低水溶性药物的溶出度得到改善。