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公开(公告)号:US5376107A
公开(公告)日:1994-12-27
申请号:US965618
申请日:1992-10-22
申请人: Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai , Kazuo Murata , Kenichi Takeuchi , Shuichi Izuchi
发明人: Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai , Kazuo Murata , Kenichi Takeuchi , Shuichi Izuchi
摘要: An electrotherapeutic device for passing a DC electric current through a living organism by applying a voltage to the living organism includes a battery with an internal resistance which is high enough so that changes in the resistance value of the living organism can be disregarded. Excessive flow of current is avoided even when the resistance of the living organism fluctuates. The device is safe, easy to handle, and inexpensive. It is particularly suited for use with iontophoresis; a technology by which drugs are administered using electricity.
摘要翻译: 用于通过向生物体施加电压使直流电流通过活体的电疗装置包括具有足够高的内阻的电池,从而可以忽略生物体的电阻值的变化。 即使生物体的电阻波动,也避免电流过大。 该设备安全,易于处理,价格便宜。 特别适用于离子电渗疗法; 使用电力管理药物的技术。
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公开(公告)号:US4309414A
公开(公告)日:1982-01-05
申请号:US87574
申请日:1979-10-23
申请人: Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai
发明人: Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai
CPC分类号: A61K47/38 , A61K31/405 , A61K47/18 , A61K47/32 , A61K9/0014
摘要: An antiinflammatory analgesic gelled ointment is disclosed which comprises indomethacin, a medium consisting of a glycol, alcohol and water, a gelling agent selected from cellulose and a carboxyvinyl polymer which has been neutralized with an amine, and water sufficiently enough to make up the balance. Such gelled ointment has an excellent antiinflammatory activity.
摘要翻译: 公开了一种消炎止痛凝胶软膏,其包含吲哚美辛,由二醇,醇和水组成的培养基,选自纤维素和已用胺中和的羧基乙烯基聚合物的胶凝剂,以及足够足以构成平衡的水。 这种凝胶软膏具有优异的抗炎活性。
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公开(公告)号:US4525347A
公开(公告)日:1985-06-25
申请号:US468491
申请日:1983-02-22
申请人: Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai
发明人: Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai
CPC分类号: A61K31/405 , A61K47/18 , A61K47/32 , A61K47/38 , A61K9/0014
摘要: An antiinflammatory analgesic ointment comprising: (a) an antiinflammatory amount of indomethacin; (b) a medium consisting of a hydroxy compound in the range of from 15 to 85% by weight, water in the range of 30 to 55% by weight and a gelating agent being present in an amount sufficient to effect gelation of said ointment and selected from the group consisting of a cellulose compound and a carboxyvinyl polymer which has been neutralized with aqueous ammonia or an amine; (c) an adjuvant being present in the range of from 0.5 to 5% by weight and selected from the group consisting of a C.sub.1 -C.sub.5 alcohol ester of a C.sub.4 -C.sub.14 monocarboxylic acid and a C.sub.1 -C.sub.3 alcohol diester of a C.sub.4 -C.sub.10 dicarboxylic acid; and (d) water in an amount sufficient to make up the balance of the ointment, said ointment being adjusted in its pH from an acidic to slightly basic level sufficient to solubilize said indomethacin in the composition but not too basic a pH level to cause decomposition of said indomethacin.
摘要翻译: 一种抗炎止痛软膏,其包含:(a)抗炎剂量的吲哚美辛; (b)由15至85重量%的羟基化合物,30至55重量%的水和80至55重量%的水,和足以使所述软膏发生凝胶化的量的凝胶剂, 选自纤维素化合物和已经用氨水或胺中和的羧基乙烯基聚合物; (c)佐剂以0.5-5重量%的范围存在,并且选自C 4 -C 14单羧酸的C 1 -C 5醇酯和C 4 -C 10的C 1 -C 3醇二酯 二羧酸 和(d)足以构成软膏平衡的量的水,所述软膏的pH值从酸性至碱性水平调节至足以将所述吲哚美辛溶解于组合物中,但不过多碱性的pH值导致分解 的所述吲哚美辛。
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公开(公告)号:US4390520A
公开(公告)日:1983-06-28
申请号:US248912
申请日:1981-03-30
申请人: Hidetaka Nagai , Yasushi Wada , Ichiro Kobayashi , Mitsuru Tamada , Keiichi Ushiyama , Toshiyuki Yamamoto
发明人: Hidetaka Nagai , Yasushi Wada , Ichiro Kobayashi , Mitsuru Tamada , Keiichi Ushiyama , Toshiyuki Yamamoto
CPC分类号: A61K9/7061 , A61L15/58
摘要: An antiphlogistic analgesic adhesive which comprisesa flexible substrate andan indomethacin containing pressure-sensitive adhesive layer closely contacting said flexible substrate, wherein said pressure-sensitive adhesive layer comprises a mixture of(a) indomethacin,(b) a copolymer of (i) an alkyl acrylate having 4 to 11 carbon atoms in the alkyl moiety and (ii) a functional monomer having a functional group in the molecule thereof and/or a vinyl monomer, which has pressure-sensitive adhesive properties at room temperature, and(c) an absorption accelerating assistant which maintains said indomethacin in a solubilized state in said copolymer and has skin diffusibility.
摘要翻译: 一种消炎镇痛粘合剂,其包含柔性基底和与所述柔性基底紧密接触的含有吲哚美辛的压敏粘合剂层,其中所述压敏粘合剂层包含(a)吲哚美辛,(b)(i) 烷基部分中具有4〜11个碳原子的丙烯酸烷基酯和(ⅱ)在其分子中具有官能团的官能单体和/或在室温下具有压敏粘合性能的乙烯基单体,和(c) 吸收加速助剂,其将所述吲哚美辛维持在所述共聚物中的溶解状态,并具有皮肤扩散性。
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公开(公告)号:US3946105A
公开(公告)日:1976-03-23
申请号:US334877
申请日:1973-02-22
申请人: Hidetaka Nagai , Eiichi Sato , Fujio Kobayashi
发明人: Hidetaka Nagai , Eiichi Sato , Fujio Kobayashi
CPC分类号: C07K16/303 , G01N33/54313 , Y10S530/829
摘要: A diagnostic agent for primary hepatoma which has anti-.alpha.1-fetoglobulin, and a process for the preparation of the diagnostic agent for primary hepatoma which comprises the steps of dissolving the anti-.alpha.1-fetoglobulin together with a support medium and allowing the same to solidify in a diffused condition.
摘要翻译: 一种具有抗α1-毛球蛋白的原发性肝癌诊断剂及其制备原发性肝癌诊断剂的方法,该方法包括以下步骤:将抗α1-毛球蛋白与支持培养基一起溶解并使其相同 以扩散状态凝固。
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