摘要:
The invention relates to compounds of the formula or a pharmaceutically acceptable salt, prodrug or hydrates thereof. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.
摘要:
4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
摘要:
A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
摘要:
4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
摘要:
A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
摘要:
In one aspect, pharmaceutical compositions comprising dispersions of an acid-sensitive drug and a neutral dispersion polymer are disclosed. The acid-sensitive drug has improved chemical stability relative to dispersions of the drug and acidic polymers. In another aspect, pharmaceutical compositions of low-solubility drugs and amphiphilic, hydroxy-functional vinyl copolymers are disclosed.
摘要:
Solid compositions with improved physical stability comprise an amorphous, low-solubility drug, a poloxamer, and a stabilizing polymer. The compositions provide good physical stability during storage and concentration enhancement of dissolved drug when administered to an aqueous environment of use.
摘要:
A power loss retraction architecture is provided to retract the VCM arm of a hard disk drive upon power loss. The power loss retraction architecture is configurable to be able to use energy from different sources. The selected energy source is used efficiently by applying the energy only to the VCM retract arrangement, while isolating the energy source from other circuits that are not needed to accomplish the retraction operation.
摘要:
A switched capacitor regulator in accordance with the present invention comprises a DC voltage source, a plurality of switches, a pumping capacitor, and a load capacitor. The plurality of switches may comprise semiconductor switches implemented in an integrated circuit (IC). The plurality of switches is configured to operate the switched capacitor regulator to place the regulator into a first charging stage and, alternately, a second charging stage. The switching between the first stage and the second stage results in the pumping capacitor being charged in opposing directions, while the load capacitor is always being charged in the same direction. The load capacitor is thus being charged in both the first charging stage and the second charging stage.