公开(公告)号：US08877907B2

公开(公告)日：2014-11-04

申请号：US13152342

申请日：2011-06-03

申请人： Tracy J. Terry ,  Andrew F. Mason ,  Carl A. Marrese

发明人： Tracy J. Terry ,  Andrew F. Mason ,  Carl A. Marrese

IPC分类号： C08B37/08 ,  C02F1/42 ,  C02F1/28 ,  C08F251/00 ,  C02F101/10 ,  C02F101/20

CPC分类号： C02F1/42 ,  C02F1/285 ,  C02F2001/422 ,  C02F2101/103 ,  C02F2101/105 ,  C02F2101/20 ,  C08B37/003 ,  C08F251/00 ,  Y10S210/906 ,  Y10S210/907 ,  C08F220/32

摘要： Disclosed is a cross-linked molecularly imprinted polymer including cross-linked chitosan having selective binding sites for phosphate ions, phosphate containing molecules, or a combination of both.

摘要翻译： 公开了一种交联分子印迹聚合物，其包括具有磷酸根离子选择性结合位点，含磷酸盐分子或两者的组合的交联壳聚糖。

公开(公告)号：US20110303611A1

公开(公告)日：2011-12-15

申请号：US13152342

申请日：2011-06-03

申请人： Tracy J. Terry ,  Andrew F. Mason ,  Carl A. Marrese

发明人： Tracy J. Terry ,  Andrew F. Mason ,  Carl A. Marrese

IPC分类号： C02F1/42 ,  C08F251/00 ,  C08B37/08

CPC分类号： C02F1/42 ,  C02F1/285 ,  C02F2001/422 ,  C02F2101/103 ,  C02F2101/105 ,  C02F2101/20 ,  C08B37/003 ,  C08F251/00 ,  Y10S210/906 ,  Y10S210/907 ,  C08F220/32

摘要： Disclosed is a cross-linked molecularly imprinted polymer including cross-linked chitosan having selective binding sites for phosphate ions, phosphate containing molecules, or a combination of both.

摘要翻译： 公开了一种交联分子印迹聚合物，其包括具有磷酸根离子选择性结合位点，含磷酸盐分子或两者的组合的交联壳聚糖。

公开(公告)号：US20090197297A1

公开(公告)日：2009-08-06

申请号：US12360372

申请日：2009-01-27

申请人： George M. Murray ,  Andrew F. Mason ,  Edward W. Ott, JR.

发明人： George M. Murray ,  Andrew F. Mason ,  Edward W. Ott, JR.

IPC分类号： C12Q1/02 ,  G01N21/00 ,  C12M1/00 ,  G01N21/77 ,  G01N33/48 ,  G01N33/02

CPC分类号： G01N21/78 ,  G01N33/543 ,  G01N2600/00 ,  Y10T436/11 ,  Y10T436/142222 ,  Y10T436/147777 ,  Y10T436/201666 ,  Y10T436/21

摘要： A molecularly imprinted polymer sensor device for detecting the presence of a taggant molecular structure in a fluid is disclosed. The molecularly imprinted polymer sensor device comprises a molecularly imprinted crosslinked polymer having a crosslinked core and a plurality of polymer arms attached to the core, wherein the core has molecular sized cavities adapted to selectively receive and bind displacement molecules having the taggant molecular structure and a colorimetric indicator, said displacement molecule being selectively removed from the molecularly imprinted crosslinked polymer and replaced with the taggant molecular structure upon exposure to the fluid containing the taggant molecular structure therein, thereby indicating the presence of the taggant molecular structure in the fluid.

摘要翻译： 公开了一种分子印迹聚合物传感器装置，用于检测流体中标签分子结构的存在。 分子印迹聚合物传感器装置包括分子印迹的交联聚合物，其具有交联的芯和连接到芯的多个聚合物臂，其中芯具有分子尺寸的空腔，其适于选择性地接收和结合具有标记分子结构的置换分子和比色 指示剂，所述置换分子从分子印迹的交联聚合物中选择性地除去，并且在暴露于含有其中的标记分子结构的流体时被标记分子结构置换，从而表明流体中存在标记分子结构。

公开(公告)号：US07664747B2

公开(公告)日：2010-02-16

申请号：US11563628

申请日：2006-11-27

申请人： Gregory J. Petras ,  Richard W. Hill ,  Andrew F. Mason ,  Cory Osborn ,  Flori N. Parham ,  Connie Riffel ,  Rachael A. Thomas ,  Craig P. Thompson ,  Jeffrey T. Zywicki

发明人： Gregory J. Petras ,  Richard W. Hill ,  Andrew F. Mason ,  Cory Osborn ,  Flori N. Parham ,  Connie Riffel ,  Rachael A. Thomas ,  Craig P. Thompson ,  Jeffrey T. Zywicki

IPC分类号： G06F17/30

CPC分类号： G06F17/30699 ,  G06F17/30716 ,  G06F17/30722 ,  Y10S707/99935 ,  Y10S707/99945

摘要： A system for automatically creating and maintaining a database of information utilizing user opinions about subjects, particularly exceptional experiences. Described is an Internet system assisting/motivating a population of users interested in information about certain categories of subjects to automatically maintain the database content and to improve the usefulness and quality of the database information without any substantial management by the website owner-manager. The user opinions are primarily in the form of both comments and ratings about which natural-language terms best describe a particular subject, enabling user searches of the subject database to be by way of preferred such descriptive natural-language terms, which terms are further preferred to be evaluative and approving.

摘要翻译： 使用用户对主题的意见，特别是特殊的体验，自动创建和维护信息数据库的系统。 描述了一种互联网系统，其帮助/激励对某些类别的主题的信息感兴趣的用户群体，以自动维护数据库内容并且提高数据库信息的有用性和质量，而无需网站所有者管理者的任何实质性管理。 用户意见主要是以自然语言术语最好地描述特定主题的评论和评级的形式，使得主题数据库的用户可以通过优先选择这样的描述性自然语言术语来进行搜索，这些术语更优选 进行评估和批准。

公开(公告)号：US07143089B2

公开(公告)日：2006-11-28

申请号：US09782873

申请日：2001-02-10

申请人： Gregory J. Petras ,  Richard W. Hill ,  Andrew F. Mason ,  Cory Osborn ,  Flori N. Parham ,  Connie Riffel ,  Rachael A. Thomas ,  Craig P. Thompson ,  Jeffrey T. Zywicki

发明人： Gregory J. Petras ,  Richard W. Hill ,  Andrew F. Mason ,  Cory Osborn ,  Flori N. Parham ,  Connie Riffel ,  Rachael A. Thomas ,  Craig P. Thompson ,  Jeffrey T. Zywicki

IPC分类号： G06F17/30

CPC分类号： G06F17/30699 ,  G06F17/30716 ,  G06F17/30722 ,  Y10S707/99935 ,  Y10S707/99945

摘要： A system for automatically creating and maintaining a database of information utilizing user opinions about subjects, particularly exceptional experiences. Described is an Internet system assisting/motivating a population of users interested in information about certain categories of subjects to automatically maintain the database content and to improve the usefulness and quality of the database information without any substantial management by the website owner-manager. The user opinions are primarily in the form of both comments and ratings about which natural-language terms best describe a particular subject, enabling user searches of the subject database to be by way of preferred such descriptive natural-language terms, which terms are further preferred to be evaluative and approving.

摘要翻译： 使用用户对主题的意见，特别是特殊的体验，自动创建和维护信息数据库的系统。 描述了一种互联网系统，其帮助/激励对某些类别的主题的信息感兴趣的用户群体，以自动维护数据库内容并且提高数据库信息的有用性和质量，而无需网站所有者管理者的任何实质性管理。 用户意见主要是以自然语言术语最好地描述特定主题的评论和评级的形式，使得主题数据库的用户可以通过优先选择这样的描述性自然语言术语来进行搜索，这些术语更优选 进行评估和批准。

公开(公告)号：US20120288944A1

公开(公告)日：2012-11-15

申请号：US13554178

申请日：2012-07-20

申请人： George M. Murray ,  Andrew F. Mason ,  Edward W. Ott, JR.

发明人： George M. Murray ,  Andrew F. Mason ,  Edward W. Ott, JR.

IPC分类号： G01N21/78

CPC分类号： G01N21/78 ,  G01N33/543 ,  G01N2600/00 ,  Y10T436/11 ,  Y10T436/142222 ,  Y10T436/147777 ,  Y10T436/201666 ,  Y10T436/21

摘要： A method for detecting a taggant molecular structure in a fluid includes providing a molecularly imprinted polymer sensor device, contacting a molecularly imprinted crosslinked star polymer with the fluid, and correlating a color change in the fluid with the amount of the taggant molecular structure in the fluid. The device has polymer arms attached to a core, and the core has molecular sized cavities adapted to selectively receive and bind displacement molecules having the taggant molecular structure and a colorimetric indicator. The displacement molecule is selectively removed from the molecularly imprinted crosslinked polymer upon exposure to the taggant molecular structure in the fluid thereby indicating the presence of the taggant molecular structure in the fluid based on a loss of color along a length of a housing.

摘要翻译： 用于检测流体中标签分子结构的方法包括提供分子印迹的聚合物传感器装置，使分子印迹的交联星形聚合物与流体接触，并将流体中的颜色变化与流体中标签分子结构的量相关联 。 该装置具有连接到芯的聚合物臂，并且芯具有分子尺寸的空腔，其适于选择性地接收和结合具有标记分子结构的置换分子和比色指示剂。 当暴露于流体中的标记分子结构时，位移分子被选择性地从分子印迹的交联聚合物中除去，从而基于沿着壳体的长度的颜色的损失表明在流体中存在标记分子结构。

公开(公告)号：US20100198834A1

公开(公告)日：2010-08-05

申请号：US12705612

申请日：2010-02-14

申请人： Gregory J. Petras ,  Richard W. Hill ,  Andrew F. Mason ,  Cory Osborn ,  Flori N. Parham ,  Connie Riffel ,  Rachael A. Thomas ,  Craig P. Thompson ,  Jeffrey T. Zywicki

发明人： Gregory J. Petras ,  Richard W. Hill ,  Andrew F. Mason ,  Cory Osborn ,  Flori N. Parham ,  Connie Riffel ,  Rachael A. Thomas ,  Craig P. Thompson ,  Jeffrey T. Zywicki

IPC分类号： G06F17/30

CPC分类号： G06F17/30699 ,  G06F17/30716 ,  G06F17/30722 ,  Y10S707/99935 ,  Y10S707/99945

摘要： A system for automatically creating and maintaining a database of information utilizing user opinions about subjects, particularly exceptional experiences. Described is an Internet system assisting/motivating a population of users interested in information about certain categories of subjects to automatically maintain the database content and to improve the usefulness and quality of the database information without any substantial management by the website owner-manager. The user opinions are primarily in the form of both comments and ratings about which natural-language terms best describe a particular subject, enabling user searches of the subject database to be by way of preferred such descriptive natural-language terms, which terms are further preferred to be evaluative and approving.

摘要翻译： 使用用户对主题的意见，特别是特殊的体验，自动创建和维护信息数据库的系统。 描述了一种互联网系统，其帮助/激励对某些类别的主题的信息感兴趣的用户群体，以自动维护数据库内容并且提高数据库信息的有用性和质量，而无需网站所有者管理者的任何实质性管理。 用户意见主要是以自然语言术语最好地描述特定主题的评论和评级的形式，使得主题数据库的用户可以通过优先选择这样的描述性自然语言术语来进行搜索，这些术语更优选 进行评估和批准。

公开(公告)号：US08241575B2

公开(公告)日：2012-08-14

申请号：US12360372

申请日：2009-01-27

申请人： George M. Murray ,  Andrew F. Mason ,  Edward W. Ott, Jr.

发明人： George M. Murray ,  Andrew F. Mason ,  Edward W. Ott, Jr.

IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC分类号： G01N21/78 ,  G01N33/543 ,  G01N2600/00 ,  Y10T436/11 ,  Y10T436/142222 ,  Y10T436/147777 ,  Y10T436/201666 ,  Y10T436/21

摘要： A molecularly imprinted polymer sensor device for detecting the presence of a taggant molecular structure in a fluid is disclosed. The molecularly imprinted polymer sensor device comprises a molecularly imprinted crosslinked polymer having a crosslinked core and a plurality of polymer arms attached to the core, wherein the core has molecular sized cavities adapted to selectively receive and bind displacement molecules having the taggant molecular structure and a colorimetric indicator, said displacement molecule being selectively removed from the molecularly imprinted crosslinked polymer and replaced with the taggant molecular structure upon exposure to the fluid containing the taggant molecular structure therein, thereby indicating the presence of the taggant molecular structure in the fluid.

摘要翻译： 公开了一种分子印迹聚合物传感器装置，用于检测流体中标签分子结构的存在。 分子印迹聚合物传感器装置包括分子印迹的交联聚合物，其具有交联的芯和连接到芯的多个聚合物臂，其中芯具有分子尺寸的空腔，其适于选择性地接收和结合具有标记分子结构的置换分子和比色 指示剂，所述置换分子从分子印迹的交联聚合物中选择性地除去，并且在暴露于含有其中的标记分子结构的流体时被标记分子结构置换，从而表明流体中存在标记分子结构。

公开(公告)号：US08024334B2

公开(公告)日：2011-09-20

申请号：US12705612

申请日：2010-02-14

申请人： Gregory J. Petras ,  Richard W. Hill ,  Andrew F. Mason ,  Cory Osborn ,  Flori N. Parham ,  Connie Riffel ,  Rachael A. Thomas ,  Craig P. Thompson ,  Jeffrey T. Zywicki

发明人： Gregory J. Petras ,  Richard W. Hill ,  Andrew F. Mason ,  Cory Osborn ,  Flori N. Parham ,  Connie Riffel ,  Rachael A. Thomas ,  Craig P. Thompson ,  Jeffrey T. Zywicki

IPC分类号： G06F17/30

CPC分类号： G06F17/30699 ,  G06F17/30716 ,  G06F17/30722 ,  Y10S707/99935 ,  Y10S707/99945

摘要： A system for automatically creating and maintaining a database of information utilizing user opinions about subjects, particularly exceptional experiences. Described is an Internet system assisting/motivating a population of users interested in information about certain categories of subjects to automatically maintain the database content and to improve the usefulness and quality of the database information without any substantial management by the website owner-manager. The user opinions are primarily in the form of both comments and ratings about which natural-language terms best describe a particular subject, enabling user searches of the subject database to be by way of preferred such descriptive natural-language terms, which terms are further preferred to be evaluative and approving.

摘要翻译： 使用用户对主题的意见，特别是特殊的体验，自动创建和维护信息数据库的系统。 描述了一种互联网系统，其帮助/激励对某些类别的主题的信息感兴趣的用户群体，以自动维护数据库内容并且提高数据库信息的有用性和质量，而无需网站所有者管理者的任何实质性管理。 用户意见主要是以自然语言术语最好地描述特定主题的评论和评级的形式，使得主题数据库的用户可以通过优先选择这样的描述性自然语言术语来进行搜索，这些术语更优选 进行评估和批准。

公开(公告)号：US20100209516A1

公开(公告)日：2010-08-19

申请号：US12702483

申请日：2010-02-09

申请人： Jason J. Benkoski ,  Andrew F. Mason ,  Lance M. Baird ,  Jennifer L. Sample

发明人： Jason J. Benkoski ,  Andrew F. Mason ,  Lance M. Baird ,  Jennifer L. Sample

IPC分类号： A61K9/14 ,  A61K39/395 ,  A61K31/713 ,  A61K38/16 ,  A61P31/00 ,  A61P29/00 ,  A61P3/10 ,  A61P9/00 ,  A61P7/02 ,  A61P37/08

CPC分类号： B82Y5/00 ,  A61K47/6891 ,  A61K47/6903

摘要： A drug delivery system, product and method which effectuates delivery of appropriate amounts of a pharmaceutically active agent only upon stimulus of a physiological agent released during a disease event are described. A polymer that can bind to a specific biological stimulus and respond with a specific response is included. The response may be release of a pharmaceutical agent, an optical signal or a change in physical properties of the polymer. The design of associative polymers that are held together using temporary bonds which will dissolve, break apart or swell in the presence of the specific stimulus are described. One embodiment includes a reversible response to a biological stimulus.

摘要翻译： 描述了仅在疾病事件中释放的生理剂的刺激下实现适量药物活性剂的输送的药物递送系统，产品和方法。 包括可以结合特定生物刺激并且响应特定应答的聚合物。 该反应可能是药剂的释放，光学信号或聚合物的物理性能的变化。 描述了使用在特定刺激的存在下溶解，分离或溶胀的临时粘结在一起的缔合聚合物的设计。 一个实施方案包括对生物刺激的可逆响应。