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1.发明授权Implantable pressure-actuated drug delivery systems and methods of manufacture and use 有权可植入的压力驱动药物输送系统及其制造和使用方法公开(公告)号：US08696740B2
公开(公告)日：2014-04-15
申请号：US12985015
申请日：2011-01-05
申请人： Chao-Wei Hwang , Hala J. Tomey , Jon R. Rosar , Robert C. Matteson, III , George L. Coles, Jr. , Jason J. Benkoski , Morgana M. Trexler
发明人： Chao-Wei Hwang , Hala J. Tomey , Jon R. Rosar , Robert C. Matteson, III , George L. Coles, Jr. , Jason J. Benkoski , Morgana M. Trexler
IPC分类号： A61F2/82
CPC分类号： A61M31/002 , A61F2/82 , A61F2240/001 , A61F2250/0068 , A61F2250/0071 , A61K9/0012 , A61K9/0024 , A61K9/0097 , A61L31/145 , A61L31/16 , A61L33/0017 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2420/02 , B05D1/005 , C23C14/22 , Y10T29/49826
摘要： Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
摘要翻译： 可植入的压力致动系统，以响应于系统空腔和外部环境之间的压力差而递送药物和/或其它物质，以及制造和使用方法。 可以调节压力破裂膜隔膜，以在期望的破裂阈值，破裂位置，所需的破裂模式和/或期望的破裂时间内破裂。 调谐可以包括材料选择，厚度控制，表面图案化，衬底支撑图案化。 空腔可以在破裂阈值以下加压或抽真空，并且可以提供隔膜保护层以防止在周围环境中过早破裂并在植入环境内消散。 药物递送系统可以在支架内实施以在血压降低时释放物质。 空腔可以包括用于治疗血块的血栓溶解药物或其他物质。
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公开(公告)号：US09550855B2
公开(公告)日：2017-01-24
申请号：US13083819
申请日：2011-04-11
IPC分类号： C08G18/32 , C08G18/64 , C08G18/72 , C08G18/75 , C08K3/00 , C08K9/10 , C09D163/00 , C09D175/04 , C08K3/08
CPC分类号： C08G18/3228 , C08G18/6423 , C08G18/724 , C08G18/755 , C08G2150/90 , C08K3/08 , C08K9/10 , C09D163/00 , C09D175/04 , Y10T428/12111 , Y10T428/2933
摘要： A metallic microcapsule containing a polymeric microcapsule having one or more polymeric precursors encapsulated therein; and a metallic shell enclosing a volume containing the polymeric microcapsule is disclosed. Also disclosed is a self-healing coating composition comprising (a) a film-forming binder; and (b) metallic microcapsules, the metallic microcapsules being the same or different and containing a polymeric microcapsule containing one or more polymeric precursors encapsulated therein; and a metallic shell enclosing a volume containing the polymeric microcapsule.
摘要翻译： 一种含有其中封装有一种或多种聚合物前体的聚合物微胶囊的金属微胶囊; 并且公开了包围含有聚合物微胶囊的体积的金属壳。 还公开了一种自修复涂料组合物，其包含（a）成膜粘合剂; 和（b）金属微胶囊，所述金属微胶囊相同或不同，并含有其中包含一种或多种聚合物前体的聚合微胶囊; 以及包围含有聚合物微胶囊的体积的金属壳。
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公开(公告)号：US20130017405A1
公开(公告)日：2013-01-17
申请号：US13593047
申请日：2012-08-23
CPC分类号： C08G18/3228 , C08G18/6423 , C08G18/724 , C08G18/755 , C08G18/7664 , C08G2150/90 , C08K3/08 , C08K9/10 , C09D5/00 , C09D163/00 , C09D175/04 , Y10T428/12111 , Y10T428/12125
摘要： A microcapsule is disposed in a self-healing coating having zinc powder particles dispersed therein. The microcapsule includes at least a silane coupling agent encapsulated within a volume defined by a metallic or polymeric shell that is rupturable responsive to formation of a fissure in the self-healing coating.
摘要翻译： 将微胶囊设置在其中分散有锌粉末颗粒的自愈膜中。 微胶囊包括至少一种包封在由金属或聚合物壳体限定的体积内的硅烷偶联剂，其可响应于自修复涂层中裂缝的形成而破裂。
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公开(公告)号：US20110293958A1
公开(公告)日：2011-12-01
申请号：US13083819
申请日：2011-04-11
CPC分类号： C08G18/3228 , C08G18/6423 , C08G18/724 , C08G18/755 , C08G2150/90 , C08K3/08 , C08K9/10 , C09D163/00 , C09D175/04 , Y10T428/12111 , Y10T428/2933
摘要： A metallic microcapsule containing a polymeric microcapsule having one or more polymeric precursors encapsulated therein; and a metallic shell enclosing a volume containing the polymeric microcapsule is disclosed. Also disclosed is a self-healing coating composition comprising (a) a film-forming binder; and (b) metallic microcapsules, the metallic microcapsules being the same or different and containing a polymeric microcapsule containing one or more polymeric precursors encapsulated therein; and a metallic shell enclosing a volume containing the polymeric microcapsule.
摘要翻译： 一种含有其中封装有一种或多种聚合物前体的聚合物微胶囊的金属微胶囊; 并且公开了包围含有聚合物微胶囊的体积的金属壳。 还公开了一种自修复涂料组合物，其包含（a）成膜粘合剂; 和（b）金属微胶囊，所述金属微胶囊相同或不同，并含有其中包含一种或多种聚合物前体的聚合微胶囊; 以及包围含有聚合物微胶囊的体积的金属壳。
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公开(公告)号：US20120039814A1
公开(公告)日：2012-02-16
申请号：US13208874
申请日：2011-08-12
申请人： Jennifer L. Sample , Julia B. Patrone , Jason J. Benkoski , James C. Crookston , Huong Le , Jennifer L. Breidenich , Lisa A. Kelly
发明人： Jennifer L. Sample , Julia B. Patrone , Jason J. Benkoski , James C. Crookston , Huong Le , Jennifer L. Breidenich , Lisa A. Kelly
CPC分类号： A61K49/0021 , A61K9/0014 , A61K9/1075 , A61K49/0078
摘要： A topical composition includes a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein. The hydrophobic particles are derived from the same or different hydrophobic material and each hydrophobic particle has a melting point below the melting point of the respective hydrophobic material. The nanoemulsion further includes one or more pharmaceutically active agents and/or one or more chemiluminescent disease-detecting systems.
摘要翻译： 局部组合物包括其中具有亲水性涂层的多个疏水性颗粒的纳米乳剂。 疏水性颗粒来自相同或不同的疏水性材料，每个疏水性颗粒的熔点低于相应疏水性材料的熔点。 纳米乳液还包括一种或多种药学活性剂和/或一种或多种化学发光疾病检测系统。
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6.发明申请Implantable Pressure-Actuated Drug Delivery Systems and Methods of Manufacture and Use 有权植入式压力驱动药物输送系统及其制造和使用方法公开(公告)号：US20120010698A1
公开(公告)日：2012-01-12
申请号：US12985015
申请日：2011-01-05
申请人： Chao-Wei Hwang , Hala J. Tomey , Jon R. Rosar , Robert C. Matteson, III , George L. Coles, JR. , Jason J. Benkoski , Morgana M. Trexler
发明人： Chao-Wei Hwang , Hala J. Tomey , Jon R. Rosar , Robert C. Matteson, III , George L. Coles, JR. , Jason J. Benkoski , Morgana M. Trexler
CPC分类号： A61M31/002 , A61F2/82 , A61F2240/001 , A61F2250/0068 , A61F2250/0071 , A61K9/0012 , A61K9/0024 , A61K9/0097 , A61L31/145 , A61L31/16 , A61L33/0017 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2420/02 , B05D1/005 , C23C14/22 , Y10T29/49826
摘要： Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
摘要翻译： 可植入的压力致动系统，以响应于系统空腔和外部环境之间的压力差而递送药物和/或其它物质，以及制造和使用方法。 可以调节压力破裂膜隔膜，以在期望的破裂阈值，破裂位置，所需的破裂模式和/或期望的破裂时间内破裂。 调谐可以包括材料选择，厚度控制，表面图案化，衬底支撑图案化。 空腔可以在破裂阈值以下加压或抽真空，并且可以提供隔膜保护层以防止在周围环境中过早破裂并在植入环境内消散。 药物递送系统可以在支架内实施以在血压降低时释放物质。 空腔可以包括用于治疗血块的血栓溶解药物或其他物质。
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公开(公告)号：US20100209516A1
公开(公告)日：2010-08-19
申请号：US12702483
申请日：2010-02-09
IPC分类号： A61K9/14 , A61K39/395 , A61K31/713 , A61K38/16 , A61P31/00 , A61P29/00 , A61P3/10 , A61P9/00 , A61P7/02 , A61P37/08
CPC分类号： B82Y5/00 , A61K47/6891 , A61K47/6903
摘要： A drug delivery system, product and method which effectuates delivery of appropriate amounts of a pharmaceutically active agent only upon stimulus of a physiological agent released during a disease event are described. A polymer that can bind to a specific biological stimulus and respond with a specific response is included. The response may be release of a pharmaceutical agent, an optical signal or a change in physical properties of the polymer. The design of associative polymers that are held together using temporary bonds which will dissolve, break apart or swell in the presence of the specific stimulus are described. One embodiment includes a reversible response to a biological stimulus.
摘要翻译： 描述了仅在疾病事件中释放的生理剂的刺激下实现适量药物活性剂的输送的药物递送系统，产品和方法。 包括可以结合特定生物刺激并且响应特定应答的聚合物。 该反应可能是药剂的释放，光学信号或聚合物的物理性能的变化。 描述了使用在特定刺激的存在下溶解，分离或溶胀的临时粘结在一起的缔合聚合物的设计。 一个实施方案包括对生物刺激的可逆响应。
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