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公开(公告)号：US10150792B2
公开(公告)日：2018-12-11
申请号：US12941599
申请日：2010-11-08
申请人： John D. Price , Thomas Piccariello , Robert A. Oberlender , Michaela E. Mulhare , Scott B. Palmer
发明人： John D. Price , Thomas Piccariello , Robert A. Oberlender , Michaela E. Mulhare , Scott B. Palmer
IPC分类号： C07H23/00 , C07F9/00 , C08B37/08 , C08B37/00 , C07C229/76
摘要： Bismuth-containing compounds include bismuth and a biologically active agent coordinated to the bismuth. The biologically active agent includes at least one heteroatom configured for coordination with the bismuth. Coordination polymers include a polymer matrix that contains a bismuth-containing compound. Methods for modulating a pharmacokinetic property of a biologically active agent include coordinating the biologically active agent to bismuth to form a bismuth-containing compound, and administering the bismuth-containing compound orally to a patient. Methods for treating Parkinson's disease, methods for treating hypothyroidism, methods for treating ulcerative colitis, and methods for treating cancer each include administering a bismuth-containing compound to a patient.
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公开(公告)号：US07718619B2
公开(公告)日：2010-05-18
申请号：US12202096
申请日：2008-08-29
申请人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
发明人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
IPC分类号： A61K38/00 , A61K51/00 , A61K31/785 , G01N33/53 , G01N33/00
CPC分类号： A61K31/165 , A61K47/542 , C07C237/06 , Y02A50/415 , Y10S436/901 , Y10T436/173845
摘要： The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
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公开(公告)号：US07678771B2
公开(公告)日：2010-03-16
申请号：US12202146
申请日：2008-08-29
申请人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
发明人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
IPC分类号： A61K38/00 , A61K51/00 , A61K31/785 , G01N33/53 , G01N33/00
CPC分类号： A61K31/165 , A61K47/542 , C07C237/06 , Y10S436/901 , Y10T436/173845
摘要： The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
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公开(公告)号：US07678770B2
公开(公告)日：2010-03-16
申请号：US12201739
申请日：2008-08-29
申请人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
发明人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
IPC分类号： A61K38/00 , A61K51/00 , A61K31/785 , G01N33/53 , G01N33/00
CPC分类号： A61K31/165 , A61K47/542 , C07C237/06 , Y02A50/415 , Y10S436/901 , Y10T436/173845
摘要： The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
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公开(公告)号：US07659253B2
公开(公告)日：2010-02-09
申请号：US12131923
申请日：2008-06-02
申请人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
发明人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
IPC分类号： A61K38/00 , A61K51/00 , A61K31/785 , G01N33/53 , G01N33/00
CPC分类号： A61K31/27 , A61K31/165 , A61K47/542 , C07C237/06 , Y10S436/901 , Y10T436/173845
摘要： The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
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公开(公告)号：US20090186828A1
公开(公告)日：2009-07-23
申请号：US12239087
申请日：2008-09-26
申请人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
发明人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
IPC分类号： A61K38/06 , A61K31/165 , A61K38/05
CPC分类号： A61K31/165 , A61K47/542 , C07C237/06 , Y02A50/415 , Y10S436/901 , Y10T436/173845
摘要： The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
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公开(公告)号：US20090143338A1
公开(公告)日：2009-06-04
申请号：US12317931
申请日：2008-12-30
申请人： Thomas Piccariello
发明人： Thomas Piccariello
IPC分类号： A61K31/663 , A61K31/555
CPC分类号： C07F3/02 , A61K47/52 , A61K47/547 , A61K47/55 , A61K47/552 , C07F3/003 , C07F3/06 , C07H21/02
摘要： A metal coordination complex of a biologically active moiety and a metal is disclosed. The complex confers to the biologically active moiety an improved performance which can include potency, stability, absorbability, targeted delivery, and combinations thereof.
摘要翻译： 公开了生物活性部分和金属的金属配位络合物。 复合物赋予生物活性部分改进的性能，其可以包括效力，稳定性，吸收性，靶向递送及其组合。
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公开(公告)号：US20090137489A1
公开(公告)日：2009-05-28
申请号：US12203132
申请日：2008-09-02
申请人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
发明人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
IPC分类号： A61K38/08 , C07C229/02 , C07K5/06 , C07K5/08 , C07K5/10 , C07K7/06 , A61P25/00 , A61K31/198 , A61K38/05 , A61K38/06 , A61K38/07
CPC分类号： A61K31/165 , A61K47/542 , C07C237/06 , Y10S436/901 , Y10T436/173845
摘要： The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
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公开(公告)号：US20090137487A1
公开(公告)日：2009-05-28
申请号：US12202941
申请日：2008-09-02
申请人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
发明人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
CPC分类号： A61K31/165 , A61K47/542 , C07C237/06 , Y10S436/901 , Y10T436/173845
摘要： The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
摘要翻译： 本发明描述了使用包含与苯丙胺共价连接的化学部分的化合物，组合物和方法。 这些化合物和组合物可用于减少或预防滥用和过量安非他明。 这些化合物和组合物特别用于提供某些障碍（例如注意力缺陷多动障碍（ADHD），ADD，发作性睡病和肥胖）的耐药性替代治疗。 苯丙胺的口服生物利用度维持在治疗有用的剂量。 在较高剂量下，生物利用度显着降低，从而提供减少口服滥用责任的方法。 此外，本发明的化合物和组合物通过肠胃外途径（例如静脉内或鼻内给药）降低苯丙胺的生物利用度，进一步限制其滥用责任。
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公开(公告)号：US20090131534A1
公开(公告)日：2009-05-21
申请号：US12201907
申请日：2008-08-29
申请人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
发明人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
IPC分类号： A61K31/135
CPC分类号： A61K31/165 , A61K47/542 , C07C237/06 , Y10S436/901 , Y10T436/173845
摘要： The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
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