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    Carbohydrate conjugates to prevent abuse of controlled substances
    1.
    发明申请
    Carbohydrate conjugates to prevent abuse of controlled substances 有权
    碳水化合物缀合物，以防止受控物质的滥用

    公开(公告)号：US20070197451A1

    公开(公告)日：2007-08-23

    申请号：US11179801

    申请日：2005-07-13

    申请人： Travis Mickle ,  Thomas Piccariello ,  James Moncrief ,  Nancy Boerth ,  Barney Bishop

    发明人： Travis Mickle ,  Thomas Piccariello ,  James Moncrief ,  Nancy Boerth ,  Barney Bishop

    IPC分类号： A61K31/485 ,  A61K9/22

    CPC分类号： A61K9/0019 ,  A61K31/706 ,  A61K47/549

    摘要： The invention provides a “street-safe” version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or eliminating the euphoric effects that lead to substance abuse. The invention provides pharmaceutical compositions comprising a controlled substance and a carbohydrate covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive or substantially diminishes its activity and methods of using the same.

    摘要翻译： 本发明提供了一种“街道安全”的受控物质版本，其允许物质的治疗有益效果，同时减少或消除导致药物滥用的欣快效应。 本发明提供药物组合物，其包含受控物质和与所述受控物质共价结合的碳水化合物，使得所述受控物质在药理学上无活性或显着降低其活性及其使用方法。

    Abuse-resistant amphetamine prodrugs
    2.
    发明申请
    Abuse-resistant amphetamine prodrugs 有权
    滥用安非他明前药

    公开(公告)号：US20070042955A1

    公开(公告)日：2007-02-22

    申请号：US11400304

    申请日：2006-04-10

    申请人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    发明人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    IPC分类号： A61K38/16 ,  A61K38/10 ,  A61K38/08 ,  A61K38/06 ,  A61K38/05 ,  A61K38/04 ,  A61K31/198

    CPC分类号： A61K31/165 ,  A61K47/542 ,  C07C237/06 ,  Y10S436/901 ,  Y10T436/173845

    摘要： The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.

    摘要翻译： 本发明描述了使用包含与苯丙胺共价连接的化学部分的化合物，组合物和方法。 这些化合物和组合物可用于减少或预防滥用和过量安非他明。 这些化合物和组合物特别用于提供某些障碍（例如注意力缺陷多动障碍（ADHD），ADD，发作性睡病和肥胖）的耐药性替代治疗。 苯丙胺的口服生物利用度维持在治疗有用的剂量。 在较高剂量下，生物利用度显着降低，从而提供减少口服滥用责任的方法。 此外，本发明的化合物和组合物通过肠胃外途径（例如静脉内或鼻内给药）降低苯丙胺的生物利用度，进一步限制其滥用责任。

    ABUSE RESISTANT LYSINE AMPHETAMINE COMPOUNDS
    3.
    发明申请
    ABUSE RESISTANT LYSINE AMPHETAMINE COMPOUNDS 有权
    抗生素赖氨酸AMPHETAMINE化合物

    公开(公告)号：US20080086016A1

    公开(公告)日：2008-04-10

    申请号：US11745019

    申请日：2007-05-07

    申请人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Robert Oberlender ,  Thomas Piccariello ,  Bernhard Paul ,  Christopher Verbicky

    发明人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Robert Oberlender ,  Thomas Piccariello ,  Bernhard Paul ,  Christopher Verbicky

    IPC分类号： C07C233/00

    CPC分类号： A61K31/165 ,  A61K47/542 ,  C07C237/06 ,  Y02A50/415 ,  Y10S436/901 ,  Y10T436/173845

    摘要： The present invention describes compounds, compositions and methods of using the same comprising lysine covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.

    摘要翻译： 本发明描述了使用其包含与苯丙胺共价连接的赖氨酸的化合物，组合物和方法。 这些化合物和组合物可用于减少或预防滥用和过量安非他明。 这些化合物和组合物特别用于提供某些障碍（例如注意力缺陷多动障碍（ADHD），ADD，发作性睡病和肥胖）的耐药性替代治疗。 苯丙胺的口服生物利用度维持在治疗有用的剂量。 在较高剂量下，生物利用度显着降低，从而提供减少口服滥用责任的方法。 此外，本发明的化合物和组合物通过肠胃外途径（例如静脉内或鼻内给药）降低苯丙胺的生物利用度，进一步限制其滥用责任。

    Abuse-resistant amphetamine compounds
    4.
    发明申请
    Abuse-resistant amphetamine compounds 有权
    滥用安非他明类化合物

    公开(公告)号：US20050054561A1

    公开(公告)日：2005-03-10

    申请号：US10858526

    申请日：2004-06-01

    申请人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    发明人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    IPC分类号： A61K31/165 ,  A61K31/7008 ,  A61K38/16 ,  A61K47/48 ,  A61K48/00

    CPC分类号： A61K31/165 ,  A61K47/542

    摘要： The invention describes compounds, compositions and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.

    摘要翻译： 本发明描述了使用其的化合物，组合物和方法，其包含与苯丙胺共价连接的化学部分。 这些化合物和组合物可用于减少或预防滥用和过量安非他明。 这些化合物和组合物特别用于提供某些障碍（例如注意力缺陷多动障碍（ADHD），ADD，发作性睡病和肥胖）的耐药性替代治疗。 苯丙胺的口服生物利用度维持在治疗有用的剂量。 在较高剂量下，生物利用度显着降低，从而提供减少口服滥用责任的方法。 此外，本发明的化合物和组合物通过肠胃外途径（例如静脉内或鼻内给药）降低苯丙胺的生物利用度，进一步限制其滥用责任。

    Abuse resistant lysine amphetamine compounds
    5.
    发明申请
    Abuse resistant lysine amphetamine compounds 有权
    滥用抗性赖氨酸苯丙胺化合物

    公开(公告)号：US20050038121A1

    公开(公告)日：2005-02-17

    申请号：US10857619

    申请日：2004-06-01

    申请人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    发明人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    IPC分类号： A61K31/165 ,  A61K31/198 ,  A61K38/00 ,  A61K47/48

    CPC分类号： A61K31/165 ,  A61K47/542 ,  C07C237/06 ,  Y02A50/415 ,  Y10S436/901 ,  Y10T436/173845

    摘要： The present invention describes compounds, compositions and methods of using the same comprising lysine covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.

    摘要翻译： 本发明描述了使用其包含与苯丙胺共价连接的赖氨酸的化合物，组合物和方法。 这些化合物和组合物可用于减少或预防滥用和过量安非他明。 这些化合物和组合物特别用于提供某些障碍（例如注意力缺陷多动障碍（ADHD），ADD，发作性睡病和肥胖）的耐药性替代治疗。 苯丙胺的口服生物利用度维持在治疗有用的剂量。 在较高剂量下，生物利用度显着降低，从而提供减少口服滥用责任的方法。 此外，本发明的化合物和组合物通过肠胃外途径（例如静脉内或鼻内给药）降低苯丙胺的生物利用度，进一步限制其滥用责任。