公开(公告)号：US20180036453A1

公开(公告)日：2018-02-08

申请号：US15600351

申请日：2017-05-19

申请人： Trustees of Tufts College

发明人： David L. Kaplan ,  Fiorenzo G. Omenetto ,  Jeffrey K. Marchant ,  Noorjahan Panjwani ,  Brian Lawrence

IPC分类号： A61L27/36 ,  A61L27/56 ,  A61L27/38 ,  C12N5/079 ,  C12N5/00 ,  G01N33/50 ,  A61L27/22

CPC分类号： A61L27/3604 ,  A61L27/225 ,  A61L27/227 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3891 ,  A61L27/56 ,  A61L2300/412 ,  C12N5/0068 ,  C12N5/0621 ,  C12N2533/50 ,  G01N33/5044

摘要： This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.

公开(公告)号：US20160151538A1

公开(公告)日：2016-06-02

申请号：US14793464

申请日：2015-07-07

申请人： Trustees of Tufts College

发明人： David L. Kaplan ,  Fiorenzo Omenetto ,  Jeffrey K. Marchant ,  Noorjahan Panjwani ,  Brian Lawrence

IPC分类号： A61L27/36 ,  A61L27/22 ,  G01N33/50

CPC分类号： A61L27/3604 ,  A61L27/225 ,  A61L27/227 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3891 ,  A61L27/56 ,  A61L2300/412 ,  C12N5/0068 ,  C12N5/0621 ,  C12N2533/50 ,  G01N33/5044

摘要： This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.

摘要翻译： 本发明涉及一种薄片组织层，其包括含有组织特异性细胞的开槽丝素蛋白底物。 丝素蛋白底物提供了控制和培养细胞和细胞外基质发育的极好手段。 可以使用多个薄片组织层来产生组织工程化器官，例如组织工程角膜。 组织工程化器官是非免疫原性和生物相容性的。

公开(公告)号：US10478524B2

公开(公告)日：2019-11-19

申请号：US15600351

申请日：2017-05-19

申请人： Trustees of Tufts College

发明人： David L. Kaplan ,  Fiorenzo G. Omenetto ,  Jeffrey K. Marchant ,  Noorjahan Panjwani ,  Brian Lawrence

IPC分类号： A01N1/02 ,  A61L27/36 ,  A61L27/22 ,  A61L27/38 ,  A61L27/56 ,  C12N5/00 ,  C12N5/079 ,  G01N33/50

摘要： This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.

公开(公告)号：US09655993B2

公开(公告)日：2017-05-23

申请号：US14793464

申请日：2015-07-07

申请人： Trustees of Tufts College

发明人： David L. Kaplan ,  Fiorenzo Omenetto ,  Jeffrey K. Marchant ,  Noorjahan Panjwani ,  Brian Lawrence

IPC分类号： A01N1/02 ,  A61L27/36 ,  A61L27/22 ,  A61L27/38 ,  A61L27/56 ,  C12N5/00 ,  C12N5/079 ,  G01N33/50

CPC分类号： A61L27/3604 ,  A61L27/225 ,  A61L27/227 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3891 ,  A61L27/56 ,  A61L2300/412 ,  C12N5/0068 ,  C12N5/0621 ,  C12N2533/50 ,  G01N33/5044

摘要： This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.