公开(公告)号：US20110275668A1

公开(公告)日：2011-11-10

申请号：US13067191

申请日：2011-05-16

申请人： Tsunehiko Higuchi ,  Hirohisa Omiya ,  Naoki Umezawa ,  Hye-Sook Kim ,  Yusuke Wataya

发明人： Tsunehiko Higuchi ,  Hirohisa Omiya ,  Naoki Umezawa ,  Hye-Sook Kim ,  Yusuke Wataya

IPC分类号： A61K31/4709 ,  A61P33/06 ,  C07D215/46

CPC分类号： C07D401/12

摘要： Compounds with high antimalarial activity; and antimalarial drugs containing the same as an active ingredient. There are provided compounds with antimalarial activity represented by the chemical formula: (wherein R1 is H, Cl or OCH3; R2 is H or CH3; R3 is CH, CH2, C(CH3), CH(CH3) or C(CH3)2; Ar is imidazole, triazole, pyridine, benzene, pyrrole, furan, thiophene or derivatives thereof; n is 1 to 5; and m is 1 to 5). Further, there are provided antimalarial drugs containing these compounds with antimalarial activity or pharmacologically acceptable salts thereof as active ingredients.

公开(公告)号：US07973027B2

公开(公告)日：2011-07-05

申请号：US12224387

申请日：2007-02-26

申请人： Tsunehiko Higuchi ,  Hirohisa Omiya ,  Naoki Umezawa ,  Hye-Sook Kim ,  Yusuke Wataya

发明人： Tsunehiko Higuchi ,  Hirohisa Omiya ,  Naoki Umezawa ,  Hye-Sook Kim ,  Yusuke Wataya

IPC分类号： A61K31/47 ,  C07D215/46

CPC分类号： C07D401/12

摘要： Compounds with high antimalarial activity; and antimalarial drugs containing the same as an active ingredient. There are provided compounds with antimalarial activity represented by the chemical formula: (wherein R1 is H, Cl or OCH3; R2 is H or CH3; R3 is CH, CH2, C(CH3), CH(CH3) or C(CH3)2; Ar is imidazole, triazole, pyridine, benzene, pyrrole, furan, thiophene or derivatives thereof; n is 1 to 5; and m is 1 to 5). Further, there are provided antimalarial drugs containing these compounds with antimalarial activity or pharmacologically acceptable salts thereof as active ingredients.

摘要翻译： 抗疟活性高的化合物 和含有与活性成分相同的抗疟药。 提供具有化学式表示的抗疟活性化合物：其中R1为H，Cl或OCH3; R2为H或CH3; R3为CH，CH2，C（CH3），CH（CH3）或C（CH3）2 ; Ar为咪唑，三唑，吡啶，苯，吡咯，呋喃，噻吩或其衍生物; n为1至5; m为1至5）。 此外，提供了含有抗疟活性化合物的抗疟药物或其药理学上可接受的盐作为活性成分。

公开(公告)号：US20090275612A1

公开(公告)日：2009-11-05

申请号：US12224387

申请日：2007-02-26

申请人： Tsunehiko Higuchi ,  Hirohisa Omiya ,  Naoki Umezawa ,  Hye-Sook Kim ,  Yusuke Wataya

发明人： Tsunehiko Higuchi ,  Hirohisa Omiya ,  Naoki Umezawa ,  Hye-Sook Kim ,  Yusuke Wataya

IPC分类号： A61K31/4709 ,  C07D215/38 ,  A61P33/06

CPC分类号： C07D401/12

摘要： Compounds with high antimalarial activity; and antimalarial drugs containing the same as an active ingredient. There are provided compounds with antimalarial activity represented by the chemical formula: (wherein R1 is H, Cl or OCH3; R2 is H or CH3; R3 is CH, CH2, C(CH3), CH(CH3) or C(CH3)2; Ar is imidazole, triazole, pyridine, benzene, pyrrole, furan, thiophene or derivatives thereof; n is 1 to 5; and m is 1 to 5). Further, there are provided antimalarial drugs containing these compounds with antimalarial activity or pharmacologically acceptable salts thereof as active ingredients.

摘要翻译： 抗疟活性高的化合物 和含有与活性成分相同的抗疟药。 提供具有化学式表示的抗疟活性化合物：其中R1为H，Cl或OCH3; R2为H或CH3; R3为CH，CH2，C（CH3），CH（CH3）或C（CH3）2 ; Ar为咪唑，三唑，吡啶，苯，吡咯，呋喃，噻吩或其衍生物; n为1至5; m为1至5）。 此外，提供了含有抗疟活性化合物的抗疟药物或其药理学上可接受的盐作为活性成分。