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    Medicinal composition
    2.
    发明申请
    Medicinal composition 审中-公开
    药用成分

    公开(公告)号：US20060160887A1

    公开(公告)日：2006-07-20

    申请号：US10562635

    申请日：2004-07-16

    申请人： Tsuyoshi Yamagata ,  Shiro Shirakura

    发明人： Tsuyoshi Yamagata ,  Shiro Shirakura

    IPC分类号： A61K31/381

    CPC分类号： C07D495/04 ,  A61K31/137 ,  A61K31/216 ,  A61K31/38 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides a pharmaceutical composition which is useful in the treatment for overactive bladder and the like, and comprises 3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-d ihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide or a pharmaceutically acceptable salt thereof, and an anticholinergic agent.

    摘要翻译： 本发明提供一种药物组合物，其可用于治疗膀胱过度活动症等，并且包含3,3,3-三氟-2-羟基-2-甲基-N-（5,5,10-三氧代-4 ，10-二氢噻吩并[3,2-c] [1]苯并硫代-9-基）丙酰胺或其药学上可接受的盐，和抗胆碱剂。

    Therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia
    3.
    发明授权
    Therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia 失效

    公开(公告)号：US07354949B2

    公开(公告)日：2008-04-08

    申请号：US10472148

    申请日：2002-03-29

    申请人： Tsuyoshi Yamagata ,  Kaoru Atsuki ,  Tetsuji Ohno ,  Shiro Shirakura ,  Akira Karasawa

    发明人： Tsuyoshi Yamagata ,  Kaoru Atsuki ,  Tetsuji Ohno ,  Shiro Shirakura ,  Akira Karasawa

    IPC分类号： A61K31/38 ,  A61K31/44 ,  A61K31/42

    CPC分类号： C07D495/04 ,  A61K31/55

    摘要： The present invention provides a therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia comprising, as an active ingredient, a tricyclic compound represented by formula (I): [wherein R1 represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy or halogen; X1-X2-X3 represents CR5═CR6—CR7═CR8, N(O)m═CR6—CR7═CR8, CR5═CR6—N(O)m═CR8, CR5═CR6—CR7═N(O)m, CR5═CR6—O, CR5═CR6—S, O—CR7═CR8, S—CR7═CR8 or O—CR7═N; Y represents 13 CH2S—, —CH2SO—, —CH2SO2—, —CH2O—, —CH═CH—, —(CH2)p—, —SCH2—, —SOCH2—, —SO2CH2— or —OCH2—; and R2 represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkoxy, amino, mono(substituted or unsubstituted lower alkyl)-substituted amino, di(substituted or unsubstituted lower alkyl)-substituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkylamino, substituted or unsubstituted arylamino or a substituted or unsubstituted heteroalicyclic group] or a pharmaceutically acceptable salt thereof.

    Remedies for vesical hyperactivity
    4.
    发明授权
    Remedies for vesical hyperactivity 失效
    用于膀胱活动过度的补救措施

    公开(公告)号：US07276532B2

    公开(公告)日：2007-10-02

    申请号：US10472143

    申请日：2002-03-29

    申请人： Tsuyoshi Yamagata ,  Kaoru Atsuki ,  Tetsuji Ohno ,  Shiro Shirakura ,  Akira Karasawa

    发明人： Tsuyoshi Yamagata ,  Kaoru Atsuki ,  Tetsuji Ohno ,  Shiro Shirakura ,  Akira Karasawa

    IPC分类号： A61K31/38

    CPC分类号： C07D495/04 ,  A61K31/55 ,  C07D337/12

    摘要： The present invention provides a therapeutic agent for overactive bladder comprising, as an active ingredient, a tricyclic compound represented by formula (I): [wherein R1 represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like; X1—X2—X3 represents CR5═CR6—CR7═CR8, CR5═CR6—S, and the like; Y represents —CH2S—, —SOCH2—, and the like; and R2 represents a hydrogen atom, and the like] or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供一种活性过氧化物的治疗剂，其包含作为活性成分的由式（I）表示的三环化合物：其中R 1表示氢原子，取代或未取代的低级烷基，和 类似; X 1 - 2 - - - - - - - - - - - - - - - - - - （3） CR 7 -CR 8，CR 5 -CR 6 -S等; Y表示-CH 2 -S-，-SOCH 2 - 等; 和R 2表示氢原子等]或其药学上可接受的盐。

    Medicinal composition
    6.
    发明申请
    Medicinal composition 审中-公开
    药用成分

    公开(公告)号：US20060148885A1

    公开(公告)日：2006-07-06

    申请号：US10562634

    申请日：2004-07-16

    申请人： Tsuyoshi Yamagata ,  Shiro Shirakura

    发明人： Tsuyoshi Yamagata ,  Shiro Shirakura

    IPC分类号： A61K31/38 ,  A61K31/381

    CPC分类号： A61K45/06 ,  A61K31/38 ,  A61K2300/00

    摘要： The present invention provides a pharmaceutical composition which is useful in the treatment for bladder irritative symptoms accompanied by benign prostatic hyperplasia and the like, and comprises 3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide or a pharmaceutically acceptable salt thereof, and an α1-adrenoceptor antagonist.

    摘要翻译： 本发明提供了可用于治疗伴有良性前列腺增生等的膀胱刺激症状的药物组合物，并且包含3,3,3-三氟-2-羟基-2-甲基-N-（5,5 ，10-三氧代-4,10-二氢噻吩并[3,2-c] [1]苯并噻吖庚因-9-基）丙酰胺或其药学上可接受的盐和α1 - 肾上腺素能受体拮抗剂。

    Prophylatic and/or therapeutic agents for chronic musculoskeletal pain
    7.
    发明申请
    Prophylatic and/or therapeutic agents for chronic musculoskeletal pain 审中-公开
    用于慢性肌肉骨骼疼痛的预防和/或治疗剂

    公开(公告)号：US20070149555A1

    公开(公告)日：2007-06-28

    申请号：US10594684

    申请日：2005-03-30

    申请人： Hiroshi Kase ,  Isami Takahashi ,  Shunji Kunori ,  Minoru Kobayashi ,  Shizuo Shiozaki ,  Shiro Shirakura

    发明人： Hiroshi Kase ,  Isami Takahashi ,  Shunji Kunori ,  Minoru Kobayashi ,  Shizuo Shiozaki ,  Shiro Shirakura

    IPC分类号： A61K31/522

    CPC分类号： A61K31/522 ,  C07D473/06 ,  Y02A50/401

    摘要： A prophylactic and/or therapeutic agent for diseases accompanied by chronic musculoskeletal pain comprising as an active ingredient a compound having an adenosine A2A receptor antagonistic action, for example, represented by the following formula (I) (wherein R1, R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R4 represents cycloalkyl, —(CH2)n—R5 or the following formula (II); and X1 and X2 are the same or different, each representing an oxygen atom or a sulfur atom) or a pharmaceutically acceptable salt thereof.

    摘要翻译： 一种伴有慢性肌肉骨骼疼痛的疾病的预防和/或治疗剂，其包含作为活性成分的具有腺苷A 2A受体拮抗作用的化合物，例如由下式（I）表示的化合物（其中 R 1，R 2和R 3相同或不同，各自表示氢原子，低级烷基，低级烯基或低级炔基; R 4表示环烷基， - （CH 2）n - R 5 -R 5或下式（II）; 和X 1和X 2相同或不同，各自表示氧原子或硫原子）或其药学上可接受的盐。

    Agents for treating migraine
    10.
    发明申请
    Agents for treating migraine 有权
    药物治疗偏头痛

    公开(公告)号：US20070161663A1

    公开(公告)日：2007-07-12

    申请号：US10587264

    申请日：2005-01-28

    申请人： Megumi Takeuchi ,  Makoto Takayama ,  Shiro Shirakura ,  Hiroshi Kase

    发明人： Megumi Takeuchi ,  Makoto Takayama ,  Shiro Shirakura ,  Hiroshi Kase

    IPC分类号： A61K31/522

    CPC分类号： A61K31/522 ,  C07D473/08

    摘要： (wherein R1, R2 and R3 are the same or different, and represent a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R4 represents cycloalkyl, —(CH2)n—R5 or a group represented by the above formula (II); and X1 and X2 are the same or different, and represent an oxygen atom or a sulfur atom) The present invention provides, for example, agents for treating migraine comprising, as an active ingredient, a xanthine derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof.

    摘要翻译： （其中R 1，R 2和R 3相同或不同，表示氢原子，低级烷基，低级烯基或低级 炔基; R 4表示环烷基， - （CH 2 CH 2）n -R 5或由下式表示的基团： 上述式（II）; X 1和X 2相同或不同，表示氧原子或硫原子）本发明提供例如， 用于治疗偏头痛的药剂，其包含作为活性成分的由上式（I）表示的黄嘌呤衍生物或其药学上可接受的盐。