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17 条记录 (耗时 0.027 秒)

    Prophylatic and/or therapeutic agents for chronic musculoskeletal pain
    1.
    发明申请
    Prophylatic and/or therapeutic agents for chronic musculoskeletal pain 审中-公开
    用于慢性肌肉骨骼疼痛的预防和/或治疗剂

    公开(公告)号：US20070149555A1

    公开(公告)日：2007-06-28

    申请号：US10594684

    申请日：2005-03-30

    申请人： Hiroshi Kase ,  Isami Takahashi ,  Shunji Kunori ,  Minoru Kobayashi ,  Shizuo Shiozaki ,  Shiro Shirakura

    发明人： Hiroshi Kase ,  Isami Takahashi ,  Shunji Kunori ,  Minoru Kobayashi ,  Shizuo Shiozaki ,  Shiro Shirakura

    IPC分类号： A61K31/522

    CPC分类号： A61K31/522 ,  C07D473/06 ,  Y02A50/401

    摘要： A prophylactic and/or therapeutic agent for diseases accompanied by chronic musculoskeletal pain comprising as an active ingredient a compound having an adenosine A2A receptor antagonistic action, for example, represented by the following formula (I) (wherein R1, R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R4 represents cycloalkyl, —(CH2)n—R5 or the following formula (II); and X1 and X2 are the same or different, each representing an oxygen atom or a sulfur atom) or a pharmaceutically acceptable salt thereof.

    摘要翻译： 一种伴有慢性肌肉骨骼疼痛的疾病的预防和/或治疗剂，其包含作为活性成分的具有腺苷A 2A受体拮抗作用的化合物，例如由下式（I）表示的化合物（其中 R 1，R 2和R 3相同或不同，各自表示氢原子，低级烷基，低级烯基或低级炔基; R 4表示环烷基， - （CH 2）n - R 5 -R 5或下式（II）; 和X 1和X 2相同或不同，各自表示氧原子或硫原子）或其药学上可接受的盐。

    Piperidine derivatives
    4.
    发明申请
    Piperidine derivatives 审中-公开
    哌啶衍生物

    公开(公告)号：US20070185168A1

    公开(公告)日：2007-08-09

    申请号：US11547810

    申请日：2005-04-07

    申请人： Haruki Takai ,  Shunji Kunori ,  Shiro Shirakura ,  Katsumi Shinoda ,  Atsuko Mizutani ,  Koji Yamada ,  Shinichiro Toki ,  Tomoyuki Nishikawa

    发明人： Haruki Takai ,  Shunji Kunori ,  Shiro Shirakura ,  Katsumi Shinoda ,  Atsuko Mizutani ,  Koji Yamada ,  Shinichiro Toki ,  Tomoyuki Nishikawa

    IPC分类号： A61K31/4439

    CPC分类号： C07D409/14

    摘要： For example, a piperidine derivative represented by following formula (I) (wherein, —C(═O)-Z- represents —C(═O)—CH2—, —C(═O)—C(CH3)2—, —C(═O)—NH—, —C(═O)—O—, —C(═O)—S—, —C(═O)—CH2CH2—, —C(═O)—CH═CH—, —C(═O)—CH2O—, —C(═O)—CH2S—, —C(═O)—CH2CH2CH2— or —C(═O)—NR8CH2—; R1 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R2 represents a hydrogen atom or hydroxy; R3 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R5 represents a hydrogen atom, hydroxy, or the like; R6 represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkyl, or the like, etc.; R7 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like; n and k each independently represents an integer of 0 to 2; and ---- represents a single bond, or a double bond together with R4, where in case ---- is a single bond, R4 represents a hydrogen atom, hydroxy, or the like) or a pharmaceutically acceptable salt thereof and the like having an antagonistic activity for a glutamic acid receptor (NR2B/NMDA receptor) of an N-methyl-D-aspartic acid (NMDA) type containing an NR2B subunit are provided.

    摘要翻译： 例如，由下式（I）表示的哌啶衍生物（其中，-C（-O）-Z-表示-C（-O）-CH 2 - ， - C（ - -C（= O）-NH-， - C（-O）-O - ， - C（-O） - S - ， - C（-O）-CH 2 CH 2 - ， - C（-O）-CH-CH - ， - C（-O）-CH O - ， - C（-O）-CH 2 S - ， - C（-O）-CH 2 CH 2 2-CH 2 - 或-C（ - ）-NR 8 CH 2 - ; R 1 - SUP>表示氢原子，取代或未取代的低级烷基等; R 2表示氢原子或羟基; R 3表示氢原子，取代或未取代的 低级烷基等; R 5表示氢原子，羟基等; R 6表示氢原子，羟基，取代或未取代的低级烷基，或 R 7表示氢原子，卤素，取代或未取代的低级烷基等; n和k各自独立地表示0〜2的整数;＆lt; U STYLE = “ SINGLE“> ----表示单键，或与R 4连接的双键，其中如果是单键，则R” 对于N-甲基-D-葡萄糖酸的谷氨酸受体（NR2B / NMDA受体）具有拮抗作用的氨基酸或其药学上可接受的盐等） 提供了含有NR2B亚基的天冬氨酸（NMDA）型。

    Agents for treating migraine
    6.
    发明申请
    Agents for treating migraine 有权
    药物治疗偏头痛

    公开(公告)号：US20070161663A1

    公开(公告)日：2007-07-12

    申请号：US10587264

    申请日：2005-01-28

    申请人： Megumi Takeuchi ,  Makoto Takayama ,  Shiro Shirakura ,  Hiroshi Kase

    发明人： Megumi Takeuchi ,  Makoto Takayama ,  Shiro Shirakura ,  Hiroshi Kase

    IPC分类号： A61K31/522

    CPC分类号： A61K31/522 ,  C07D473/08

    摘要： (wherein R1, R2 and R3 are the same or different, and represent a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R4 represents cycloalkyl, —(CH2)n—R5 or a group represented by the above formula (II); and X1 and X2 are the same or different, and represent an oxygen atom or a sulfur atom) The present invention provides, for example, agents for treating migraine comprising, as an active ingredient, a xanthine derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof.

    摘要翻译： （其中R 1，R 2和R 3相同或不同，表示氢原子，低级烷基，低级烯基或低级 炔基; R 4表示环烷基， - （CH 2 CH 2）n -R 5或由下式表示的基团： 上述式（II）; X 1和X 2相同或不同，表示氧原子或硫原子）本发明提供例如， 用于治疗偏头痛的药剂，其包含作为活性成分的由上式（I）表示的黄嘌呤衍生物或其药学上可接受的盐。

    Medicinal composition
    8.
    发明申请
    Medicinal composition 审中-公开
    药用成分

    公开(公告)号：US20060160887A1

    公开(公告)日：2006-07-20

    申请号：US10562635

    申请日：2004-07-16

    申请人： Tsuyoshi Yamagata ,  Shiro Shirakura

    发明人： Tsuyoshi Yamagata ,  Shiro Shirakura

    IPC分类号： A61K31/381

    CPC分类号： C07D495/04 ,  A61K31/137 ,  A61K31/216 ,  A61K31/38 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides a pharmaceutical composition which is useful in the treatment for overactive bladder and the like, and comprises 3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-d ihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide or a pharmaceutically acceptable salt thereof, and an anticholinergic agent.

    摘要翻译： 本发明提供一种药物组合物，其可用于治疗膀胱过度活动症等，并且包含3,3,3-三氟-2-羟基-2-甲基-N-（5,5,10-三氧代-4 ，10-二氢噻吩并[3,2-c] [1]苯并硫代-9-基）丙酰胺或其药学上可接受的盐，和抗胆碱剂。

    Therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia
    9.
    发明授权
    Therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia 失效

    公开(公告)号：US07354949B2

    公开(公告)日：2008-04-08

    申请号：US10472148

    申请日：2002-03-29

    申请人： Tsuyoshi Yamagata ,  Kaoru Atsuki ,  Tetsuji Ohno ,  Shiro Shirakura ,  Akira Karasawa

    发明人： Tsuyoshi Yamagata ,  Kaoru Atsuki ,  Tetsuji Ohno ,  Shiro Shirakura ,  Akira Karasawa

    IPC分类号： A61K31/38 ,  A61K31/44 ,  A61K31/42

    CPC分类号： C07D495/04 ,  A61K31/55

    摘要： The present invention provides a therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia comprising, as an active ingredient, a tricyclic compound represented by formula (I): [wherein R1 represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy or halogen; X1-X2-X3 represents CR5═CR6—CR7═CR8, N(O)m═CR6—CR7═CR8, CR5═CR6—N(O)m═CR8, CR5═CR6—CR7═N(O)m, CR5═CR6—O, CR5═CR6—S, O—CR7═CR8, S—CR7═CR8 or O—CR7═N; Y represents 13 CH2S—, —CH2SO—, —CH2SO2—, —CH2O—, —CH═CH—, —(CH2)p—, —SCH2—, —SOCH2—, —SO2CH2— or —OCH2—; and R2 represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkoxy, amino, mono(substituted or unsubstituted lower alkyl)-substituted amino, di(substituted or unsubstituted lower alkyl)-substituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkylamino, substituted or unsubstituted arylamino or a substituted or unsubstituted heteroalicyclic group] or a pharmaceutically acceptable salt thereof.