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公开(公告)号：US20080114019A1
公开(公告)日：2008-05-15
申请号：US10595058
申请日：2004-08-12
申请人： Tushar A. Kshirsagar , David T. Amos , Joseph F. Dellaria, Jr. , Philip D. Heppner , Scott E. Langer , Bernhard M. Zimmermann
发明人： Tushar A. Kshirsagar , David T. Amos , Joseph F. Dellaria, Jr. , Philip D. Heppner , Scott E. Langer , Bernhard M. Zimmermann
IPC分类号： A61K31/437 , A61K31/4375 , A61P31/12 , A61P35/00 , C07D471/04 , C07D471/14
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazoquinoline compounds with an oxime substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译： 公开了在1位具有肟取代基的咪唑并喹啉化合物，含有化合物的化合物的药物组合物，中间体和这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病的疾病。
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公开(公告)号：US08673932B2
公开(公告)日：2014-03-18
申请号：US10595065
申请日：2004-08-12
申请人： Tushar A. Kshirsagar , David T. Amos , Joseph F. Dellaria, Jr. , Philip D. Heppner , Scott E. Langer , Bernhard M. Zimmermann
发明人： Tushar A. Kshirsagar , David T. Amos , Joseph F. Dellaria, Jr. , Philip D. Heppner , Scott E. Langer , Bernhard M. Zimmermann
IPC分类号： C07D487/04 , C07D487/06 , A61K31/437
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译： 在1位具有肟取代基的含咪唑的化合物（例如咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有这些化合物的化合物，中间体和使用这些化合物作为免疫调节剂的方法用于在动物中诱导细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。
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公开(公告)号：US07648997B2
公开(公告)日：2010-01-19
申请号：US10595058
申请日：2004-08-12
申请人： Tushar A. Kshirsagar , David T. Amos , Joseph F. Dellaria, Jr. , Philip D. Heppner , Scott E. Langer , Bernhard M. Zimmermann
发明人： Tushar A. Kshirsagar , David T. Amos , Joseph F. Dellaria, Jr. , Philip D. Heppner , Scott E. Langer , Bernhard M. Zimmermann
IPC分类号： A61K31/437
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, imidazopyridines) with a hydrox-ylamine substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译： 在1-位具有羟基胺取代基的含咪唑化合物（例如咪唑并喹啉，咪唑并吡啶，咪唑并吡啶），含有这些化合物的化合物的药物组合物，中间体和这些化合物作为免疫调节剂的方法，用于在动物中诱导细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。
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公开(公告)号：US08143270B2
公开(公告)日：2012-03-27
申请号：US11574460
申请日：2005-09-01
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , C07D471/14
摘要： 1H-Imidazo ring systems (e.g., imidazopyridines, imidazoquinolines, imidazonaphthyridines, 6,7,8,9-tetrahydro imidazoquinolines and imidazonaphthyridines) with an amino substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译： 在2-位具有氨基取代基的1H-咪唑环体系（例如咪唑并吡啶，咪唑并喹啉，咪唑并吡啶，6,7,8,9-四氢咪唑并喹啉和咪唑并吡啶），含这些化合物的药物组合物，制备化合物的方法，中间体 ，以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病的方法。
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公开(公告)号：US20090023720A1
公开(公告)日：2009-01-22
申请号：US11574460
申请日：2005-09-01
IPC分类号： A61K31/437 , C07D471/04 , A61K31/5377 , A61P31/12 , C07D413/14
CPC分类号： C07D471/04 , C07D471/14
摘要： 1H-Imidazo ring systems (e.g., imidazopyridines, imidazoquinolines, imidazonaphthyridines, 6,7,8,9-tetrahydro imidazoquinolines and imidazonaphthyridines) with an amino substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译： 在2-位具有氨基取代基的1H-咪唑环体系（例如咪唑并吡啶，咪唑并喹啉，咪唑并吡啶，6,7,8,9-四氢咪唑并喹啉和咪唑并吡啶），含这些化合物的药物组合物，制备化合物的方法，中间体 ，以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病的方法。
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公开(公告)号：US20090221556A1
公开(公告)日：2009-09-03
申请号：US12092625
申请日：2006-11-03
IPC分类号： A61K31/437 , C07D471/04 , C07D413/14 , C07D243/08 , A61K31/5377 , A61K31/551 , A61P37/00
CPC分类号： C07D471/04
摘要： 1H-Imidazo[4,5-c]quinolin-4-amines with a hydroxy, alkoxy, hydroxyalkoxy, or alkoxyalkoxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译： 在2-位具有羟基，烷氧基，羟基烷氧基或烷氧基烷氧基取代基的1H-咪唑并[4,5-c]喹啉-4-胺，含有这些化合物的药物组合物，制备化合物的方法，中间体和使用方法 的这些化合物作为免疫调节剂，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病的疾病。
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公开(公告)号：US08846710B2
公开(公告)日：2014-09-30
申请号：US11884982
申请日：2006-02-22
申请人： Tushar A. Kshirsagar , Bryon A. Merrill , Scott E. Langer , Kyle J. Lindstrom , Sarah C. Slania , Gregory J. Marszalek , Joshua R. Wurst , Karl J. Manske , Shri Niwas , Gregory D. Lundquist, Jr. , Philip D. Heppner , George W. Griesgraber , Michael E. Danielson
发明人： Tushar A. Kshirsagar , Bryon A. Merrill , Scott E. Langer , Kyle J. Lindstrom , Sarah C. Slania , Gregory J. Marszalek , Joshua R. Wurst , Karl J. Manske , Shri Niwas , Gregory D. Lundquist, Jr. , Philip D. Heppner , George W. Griesgraber , Michael E. Danielson
IPC分类号： A61K31/4745 , C07D471/04 , C07D471/14
CPC分类号： A61K31/4745 , C07D471/04 , C07D471/14 , Y02A50/409 , Y02A50/411 , Y02A50/481
摘要： A method of preferentially inducing IFN-α biosynthesis in an animal comprising administering certain imidazo[4,5-c] ring compounds with a hydroxymethyl or hydroxyethyl substituent at the 2-position or pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of using these compounds a immunomodulators for treatment of diseases including viral and neoplastic diseases comprising preferentially inducing IFN-α biosynthesis in an animal are disclosed.
摘要翻译： 一种在动物中优先诱导IFN-α生物合成的方法，其包括在2-位上给予某些咪唑并[4,5-c]环化合物与羟甲基或羟乙基取代基或含有化合物，中间体，制备方法和 公开了使用这些化合物的免疫调节剂用于治疗包括病毒和肿瘤疾病在内的疾病的方法，其包括在动物中优先诱导IFN-α生物合成。
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![Substituted fused[1,2] imidazo[4,5-c] ring compounds and methods](/abs-image/US/2012/01/03/US08088788B2/abs.jpg.150x150.jpg)
8.发明授权公开(公告)号：US08088788B2
公开(公告)日：2012-01-03
申请号：US12281728
申请日：2007-03-14
申请人： Tushar A. Kshirsagar , Karl J. Manske , Larry R. Krepski , Joan T. Moseman , George W. Griesgraber , Sarah Johannessen Slania , Scott E. Langer , Philip D. Heppner
发明人： Tushar A. Kshirsagar , Karl J. Manske , Larry R. Krepski , Joan T. Moseman , George W. Griesgraber , Sarah Johannessen Slania , Scott E. Langer , Philip D. Heppner
IPC分类号： A61K31/4745 , C07D471/14
CPC分类号： C07D498/14 , C07D471/14 , C07D471/22
摘要： [1,2]Imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and imidazo[4,5-c]pyridines) substituted with a fused ring containing an oxygen and/or nitrogen atom attached at the 1- and/or 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译： [1,2]咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]喹啉，咪唑并[4,5-c]萘啶和咪唑并[4,5-c]吡啶） 含有在1-和/或2-位连接的氧和/或氮原子的稠环，含有化合物的药物组合物，中间体，制备化合物的方法以及这些化合物作为免疫调节剂的用途的方法，用于诱导 公开了动物中的细胞因子生物合成和包括病毒和肿瘤疾病在内的疾病的治疗。
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公开(公告)号：US08343993B2
公开(公告)日：2013-01-01
申请号：US11885007
申请日：2006-02-22
申请人： Tushar A. Kshirsagar , Scott E. Langer , Shri Niwas , George W. Griesgraber , Philip D. Heppner , Kyle J. Lindstrom
发明人： Tushar A. Kshirsagar , Scott E. Langer , Shri Niwas , George W. Griesgraber , Philip D. Heppner , Kyle J. Lindstrom
IPC分类号： A61K31/4375 , C07D513/16
CPC分类号： C07D471/14
摘要： Certain imidazonaphthyridines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-α biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译： 某些具有2-位羟基甲基或羟乙基取代基的咪唑并吡啶类，含有化合物的药物组合物，中间体，制备方法以及这些化合物作为免疫调节剂的使用方法，用于优先诱导动物中的IFN-α生物合成和治疗疾病 包括病毒和肿瘤疾病。
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公开(公告)号：US20090030031A1
公开(公告)日：2009-01-29
申请号：US11884982
申请日：2006-02-22
申请人： Tushar A. Kshirsagar , Bryon A. Merrill , Scott E. Langer , Kyle J. Lindstrom , Sarah C. Slania , Gregory J. Marszalek , Joshua R. Wurst , Karl J. Manske , Shri Niwas , Gregory D. Lundquist, JR. , Philip D. Heppner , George W. Griesgraber , Michael E. Danielson
发明人： Tushar A. Kshirsagar , Bryon A. Merrill , Scott E. Langer , Kyle J. Lindstrom , Sarah C. Slania , Gregory J. Marszalek , Joshua R. Wurst , Karl J. Manske , Shri Niwas , Gregory D. Lundquist, JR. , Philip D. Heppner , George W. Griesgraber , Michael E. Danielson
IPC分类号： A61K31/4375 , A61K31/437 , A61P35/00 , A61P31/12
CPC分类号： A61K31/4745 , C07D471/04 , C07D471/14 , Y02A50/409 , Y02A50/411 , Y02A50/481
摘要： A method of preferentially inducing IFN-α biosynthesis in an animal comprising administering certain imidazo[4,5-c] ring compounds with a hydroxymethyl or hydroxyethyl substituent at the 2-position or pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of using these compounds a immunomodulators for treatment of diseases including viral and neoplastic diseases comprising preferentially inducing IFN-α biosynthesis in an animal are disclosed.
摘要翻译： 一种在动物中优先诱导IFN-α生物合成的方法，其包括在2-位上给予某些咪唑并[4,5-c]环化合物与羟甲基或羟乙基取代基或含有化合物，中间体，制备方法和 公开了使用这些化合物的免疫调节剂用于治疗疾病的方法，所述疾病包括在动物中优先诱导IFN-α生物合成的病毒和肿瘤疾病。
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