公开(公告)号：US20200347011A1

公开(公告)日：2020-11-05

申请号：US16760755

申请日：2018-11-02

申请人： UBE INDUSTRIES, LTD.

发明人： Haruka YAMADA ,  Ken-ichi KOMORI ,  Yusuke SHIRAISHI ,  Satoshi UMEZAKI ,  Naoya KINOSHITA ,  Koji ITO ,  Tomoko KANDA ,  Kenji YONEDA ,  Yasunori TOKUNAGA ,  Tomio KIMURA

IPC分类号： C07C307/06 ,  C07C279/18 ,  C07D407/12 ,  A61P3/04

摘要： The present invention provides a compound that is highly safe and useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical composition containing the compound, a method for producing the compound, and the like. Specifically, the present invention provides a compound represented by the following general formula (I): [wherein: A1 and A2 each independently represent an inhibitor residue having at least one activity selected from an enteropeptidase inhibitory activity and a trypsin inhibitory activity; and Z represents a spacer that links A1 to A2] or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20190337962A1

公开(公告)日：2019-11-07

申请号：US16474339

申请日：2017-12-27

申请人： UBE INDUSTRIES, LTD.

发明人： Ken-ichi KOMORI ,  Akishi NINOMIYA ,  Shigeru USHIYAMA ,  Masaru SHINOHARA ,  Koji ITO ,  Tetsuo KAWAGUCHI ,  Yasunori TOKUNAGA ,  Hiroyoshi KAWADA ,  Haruka YAMADA ,  Yusuke SHIRAISHI ,  Masahiro KOJIMA ,  Masaaki ITO ,  Tomio KIMURA

IPC分类号： C07D491/107 ,  C07D401/04 ,  C07D405/12

摘要： The present invention provides a compound of general formula (I) (wherein X is as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

公开(公告)号：US20220259223A1

公开(公告)日：2022-08-18

申请号：US17614941

申请日：2020-05-29

申请人： UBE INDUSTRIES, LTD.

发明人： Ken-ichi KOMORI ,  Hayato NISHIYAMA ,  Naoya KINOSHITA ,  Yukinori WADA ,  Kousuke MORISHITA ,  Akishi NINOMIYA ,  Yuusuke SHIRAISHI ,  Kazuhiro ONUMA ,  Sayaka OGI ,  Hiroyoshi KAWADA ,  Tomio KIMURA

IPC分类号： C07D498/04 ,  C07D413/10 ,  A61P1/16

摘要： The present invention provides a compound having Keap1 inhibitory effects and a pharmaceutical composition containing the same. Specifically, the present invention provides a compound represented by the following general formula (I): [wherein the symbols have the same meanings as those described in the description] or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing the same.

公开(公告)号：US20190152953A1

公开(公告)日：2019-05-23

申请号：US15750583

申请日：2016-08-05

申请人： UBE INDUSTRIES, LTD.

发明人： Ken-ichi KOMORI ,  Akishi NINOMIYA ,  Shigeru USHIYAMA ,  Masaru SHINOHARA ,  Koji ITO ,  Tetsuo KAWAGUCHI ,  Yasunori TOKUNAGA ,  Hiroyoshi KAWADA ,  Haruka YAMADA ,  Yusuke SHIRAISHI ,  Masahiro KOJIMA ,  Masaaki ITO ,  Tomio KIMURA

IPC分类号： C07D403/04 ,  C07F7/08 ,  C07D405/14 ,  C07D401/04 ,  C07D403/14 ,  C07D413/14 ,  C07D401/14 ,  C07C59/255 ,  C07C57/145 ,  C07C55/10

摘要： The present invention provides a compound of general formula (I) (wherein, R1, X, p and q are as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.