公开(公告)号：US20190152953A1

公开(公告)日：2019-05-23

申请号：US15750583

申请日：2016-08-05

申请人： UBE INDUSTRIES, LTD.

发明人： Ken-ichi KOMORI ,  Akishi NINOMIYA ,  Shigeru USHIYAMA ,  Masaru SHINOHARA ,  Koji ITO ,  Tetsuo KAWAGUCHI ,  Yasunori TOKUNAGA ,  Hiroyoshi KAWADA ,  Haruka YAMADA ,  Yusuke SHIRAISHI ,  Masahiro KOJIMA ,  Masaaki ITO ,  Tomio KIMURA

IPC分类号： C07D403/04 ,  C07F7/08 ,  C07D405/14 ,  C07D401/04 ,  C07D403/14 ,  C07D413/14 ,  C07D401/14 ,  C07C59/255 ,  C07C57/145 ,  C07C55/10

摘要： The present invention provides a compound of general formula (I) (wherein, R1, X, p and q are as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

公开(公告)号：US20160213657A1

公开(公告)日：2016-07-28

申请号：US14915805

申请日：2014-09-02

申请人： UBE INDUSTRIES, LTD.

发明人： Kenji YONEDA ,  Nobuhiko SHIBAKAWA ,  Tetsushi KATSUBE ,  Tomoko KANDA ,  Koji ITO ,  Kiyoshi YAMAMOTO ,  Masaru SHINOHARA ,  Noriaki IWASE ,  Shigeru USHIYAMA

IPC分类号： A61K31/44 ,  A61K31/4436 ,  A61K31/444

CPC分类号： A61K31/44 ,  A61K31/4436 ,  A61K31/444

摘要： Provided is a pharmaceutical composition containing, as an active ingredient thereof, a substituted biaryl compound represented by general formula (I), wherein, R1, W, R2 and Z are as defined in the claims and description, or a pharmacologically acceptable salt thereof. The pharmaceutical composition of the present invention is useful as a therapeutic drug and/or prophylactic drug for chronic obstructive pulmonary disease due to having an excellent anti-inflammatory effect.

摘要翻译： 本发明提供含有通式（I）所示的取代的联芳基化合物作为活性成分的药物组合物，其中，R1，W，R2和Z如权利要求和说明书所定义，或其药理学上可接受的盐。 由于具有优异的抗炎作用，本发明的药物组合物可用作慢性阻塞性肺疾病的治疗药物和/或预防药物。

公开(公告)号：US20200347011A1

公开(公告)日：2020-11-05

申请号：US16760755

申请日：2018-11-02

申请人： UBE INDUSTRIES, LTD.

发明人： Haruka YAMADA ,  Ken-ichi KOMORI ,  Yusuke SHIRAISHI ,  Satoshi UMEZAKI ,  Naoya KINOSHITA ,  Koji ITO ,  Tomoko KANDA ,  Kenji YONEDA ,  Yasunori TOKUNAGA ,  Tomio KIMURA

IPC分类号： C07C307/06 ,  C07C279/18 ,  C07D407/12 ,  A61P3/04

摘要： The present invention provides a compound that is highly safe and useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical composition containing the compound, a method for producing the compound, and the like. Specifically, the present invention provides a compound represented by the following general formula (I): [wherein: A1 and A2 each independently represent an inhibitor residue having at least one activity selected from an enteropeptidase inhibitory activity and a trypsin inhibitory activity; and Z represents a spacer that links A1 to A2] or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20190337962A1

公开(公告)日：2019-11-07

申请号：US16474339

申请日：2017-12-27

申请人： UBE INDUSTRIES, LTD.

发明人： Ken-ichi KOMORI ,  Akishi NINOMIYA ,  Shigeru USHIYAMA ,  Masaru SHINOHARA ,  Koji ITO ,  Tetsuo KAWAGUCHI ,  Yasunori TOKUNAGA ,  Hiroyoshi KAWADA ,  Haruka YAMADA ,  Yusuke SHIRAISHI ,  Masahiro KOJIMA ,  Masaaki ITO ,  Tomio KIMURA

IPC分类号： C07D491/107 ,  C07D401/04 ,  C07D405/12

摘要： The present invention provides a compound of general formula (I) (wherein X is as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

公开(公告)号：US20160060221A1

公开(公告)日：2016-03-03

申请号：US14780249

申请日：2014-03-28

申请人： UBE INDUSTRIES LTD.

发明人： Nobuhiko SHIBAKAWA ,  Kenji YONEDA ,  Tetsushi KATSUBE ,  Tomoko KANDA ,  Koji ITO ,  Kiyoshi YAMAMOTO ,  Noriaki IWASE ,  Shigeru USHIYAMA

IPC分类号： C07D213/74 ,  C07D409/12

CPC分类号： C07D213/74 ,  C07D409/12

摘要： The present invention provides a substituted biaryl compound of general formula (I): wherein, R1, W, R2, and Z are as defined in the claims and the description, or a pharmacologically acceptable salt thereof. The compound according to the present invention has an excellent inhibition effect of pulmonary fibroblast proliferation, and is therefore useful as a therapeutic agent and/or a prophylactic agent for interstitial pneumonia and pulmonary fibrosis.

摘要翻译： 本发明提供通式（I）的取代的联芳基化合物：其中R1，W，R2和Z如权利要求书和说明书中所定义，或其药理学上可接受的盐。 根据本发明的化合物对肺成纤维细胞增殖具有优异的抑制作用，因此可用作间质性肺炎和肺纤维化的治疗剂和/或预防剂。