公开(公告)号：US20200291104A1

公开(公告)日：2020-09-17

申请号：US16063133

申请日：2016-12-14

Applicant: UCB BIOPHARMA SPRL

Inventor： Ralph Adams ,  Pallavi Bhatta ,  Emma Dave ,  Sam Philip Heywood ,  Dave Paul Humphreys ,  Diane Marshall ,  Daniel John Lightwood

IPC: C07K16/24 ,  C12N15/63

Abstract: The invention relates to antibody molecules having specificity for TNF alpha, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：US10421814B2

公开(公告)日：2019-09-24

申请号：US15883130

申请日：2018-01-30

Applicant: UCB BIOPHARMA SPRL

Inventor： Graham Craggs ,  Karine Jeannine Madeleine Herve ,  Diane Marshall

IPC: C07K16/28 ,  C07K16/00 ,  A61K38/18 ,  A61K39/00

Abstract: The present invention relates to an anti-CSF-1R antibody and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The present invention also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment.

公开(公告)号：US09908939B2

公开(公告)日：2018-03-06

申请号：US14914676

申请日：2014-08-26

Applicant: UCB BIOPHARMA SPRL

Inventor： Graham Craggs ,  Karine Jeannine Madeleine Hervé ,  Diane Marshall

IPC: C07K16/28 ,  C07K16/00 ,  C12P21/08 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention relates to an anti-CSF-1R antibody and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The present invention also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment.

公开(公告)号：US10766956B2

公开(公告)日：2020-09-08

申请号：US16307444

申请日：2017-06-07

Applicant: UCB BIOPHARMA SPRL

Inventor： Helene Bon ,  Joanne Elizabeth Compson ,  Kate Louise Dixon ,  Carl Brendan Doyle ,  Mark Ellis ,  Maria Margarida Gouveia Sancho ,  Raymond Anthony Jupp ,  Lara Kevorkian ,  Daniel John Lightwood ,  Diane Marshall ,  Andrew Charles Payne ,  Joseph Michael David Rastrick ,  Monika-Sarah Schulze ,  Alison Turner ,  Kerry Louise Tyson

IPC: C07K16/22 ,  A61P11/00 ,  A61K9/00 ,  A61P11/12 ,  A61K39/395

Abstract: The present disclosure relates to TGF-beta antibodies and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The disclosure also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment of various diseases including fibrosis.