公开(公告)号：US10766956B2

公开(公告)日：2020-09-08

申请号：US16307444

申请日：2017-06-07

Applicant: UCB BIOPHARMA SPRL

Inventor： Helene Bon ,  Joanne Elizabeth Compson ,  Kate Louise Dixon ,  Carl Brendan Doyle ,  Mark Ellis ,  Maria Margarida Gouveia Sancho ,  Raymond Anthony Jupp ,  Lara Kevorkian ,  Daniel John Lightwood ,  Diane Marshall ,  Andrew Charles Payne ,  Joseph Michael David Rastrick ,  Monika-Sarah Schulze ,  Alison Turner ,  Kerry Louise Tyson

IPC: C07K16/22 ,  A61P11/00 ,  A61K9/00 ,  A61P11/12 ,  A61K39/395

Abstract: The present disclosure relates to TGF-beta antibodies and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The disclosure also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment of various diseases including fibrosis.

公开(公告)号：US20200291104A1

公开(公告)日：2020-09-17

申请号：US16063133

申请日：2016-12-14

Applicant: UCB BIOPHARMA SPRL

Inventor： Ralph Adams ,  Pallavi Bhatta ,  Emma Dave ,  Sam Philip Heywood ,  Dave Paul Humphreys ,  Diane Marshall ,  Daniel John Lightwood

IPC: C07K16/24 ,  C12N15/63

Abstract: The invention relates to antibody molecules having specificity for TNF alpha, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：US10775385B2

公开(公告)日：2020-09-15

申请号：US15736614

申请日：2015-10-22

Applicant: UCB Biopharma SPRL

Inventor： James Philip O'Connell ,  John Robert Porter ,  Alastair Lawson ,  Boris Kroeplien ,  Stephen Edward Rapecki ,  Timothy John Norman ,  Graham John Warrellow ,  Tracy Lynn Arakaki ,  Alex Buntin Burgin ,  William Ross Pitt ,  Mark Daniel Calmiano ,  David Andreas Schubert ,  Daniel John Lightwood ,  Rebecca Jayne Wootton

IPC: G01N33/68 ,  C07K14/525 ,  C07K14/705 ,  C07K16/24 ,  A61P37/00 ,  C07D401/14 ,  C07D471/00 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D471/04 ,  A61K47/64 ,  A61P35/00

Abstract: A new, stable trimeric TNFα structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNFα/TNFR1 interaction. Membrane-bound TNFα is not affected in its ability to signal through TNFR2, and thus the new structure of TNFα may be used in therapies which do not significantly raise the risk of infection or malignancy.

公开(公告)号：US20200377578A1

公开(公告)日：2020-12-03

申请号：US16919576

申请日：2020-07-02

Applicant: UCB Biopharma SPRL

Inventor： David Paul Humphreys ,  Daniel John Lightwood ,  Kerry Louise Tyson ,  David Edward Ormonde Knight ,  Karine Jeannine Madeleine Hervé ,  Joanne Elizabeth Compson ,  Matthew Jon Timothy Page ,  Andrew Charles Payne ,  Nicola Louise Fisher ,  Brendon MacKenzie ,  Matthew Cox

IPC: C07K16/12 ,  A61K39/40 ,  A61K45/06 ,  G01N33/569 ,  G01N33/573 ,  G01N33/68

Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.

公开(公告)号：US09957320B2

公开(公告)日：2018-05-01

申请号：US15180916

申请日：2016-06-13

Applicant: UCB BIOPHARMA SPRL

Inventor： Neil Gozzard ,  Alastair David Griffiths Lawson ,  Daniel John Lightwood ,  Roger Thomas Palframan ,  Bryan John Smith ,  Kerry Louise Tyson

IPC: C07K16/24 ,  A61K39/395 ,  A61K9/00 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K9/0078 ,  A61K39/395 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/544 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing antibody molecules.

公开(公告)号：US20160289323A1

公开(公告)日：2016-10-06

申请号：US15180916

申请日：2016-06-13

Applicant: UCB BIOPHARMA SPRL

Inventor： Neil Gozzard ,  Alastair David Griffiths Lawson ,  Daniel John Lightwood ,  Roger Thomas Palframan ,  Bryan John Smith ,  Kerry Louise Tyson

IPC: C07K16/24 ,  A61K9/00 ,  A61K39/395

CPC classification number: C07K16/244 ,  A61K9/0078 ,  A61K39/395 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/544 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

Abstract translation: 本发明涉及对人IL-13的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。