公开(公告)号：US20220242855A1

公开(公告)日：2022-08-04

申请号：US17621877

申请日：2020-06-24

申请人： UCB Biopharma SRL

发明人： Shuyu Chu ,  Helen Tracey Horsley ,  James Thomas Reuberson ,  Richard David Taylor ,  Zhaoning Zhu ,  Rose Elizabeth Chappell ,  Gregory William Haslett ,  Adam Peter Smalley ,  Nathaniel Julius Thomas Monck ,  Gareth Neil Brace ,  Prafulkumar Tulshibhai Chovatia

IPC分类号： C07D405/14 ,  C07D487/04 ,  A61K45/06 ,  A61K31/501 ,  A61K31/519 ,  A61K31/4353 ,  C07D498/04 ,  A61K31/4245 ,  A61K31/4439 ,  A61K31/497 ,  C07D417/14

摘要： A series of substituted fused bicyclic imidazole derivatives of formula (I), including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments including inflammatory and autoimmune disorders, wherein i. a. A represents C—R1 or N; B represents C—R2 or N; D represents C—R3 or N; E represents C—R4 or N; Z represents —CH(R5)N(H)CH2R6, —CH(R5)N(H)S(O)2R6, —C(═CR5aR5b)N(H)C(O)R6, —CH(R5)R7, —CH(R5)N(H)R7 or —CH(R5)C(O)N(H)R7; R0 represents hydrogen or C1-6 alkyl.

公开(公告)号：US11052076B2

公开(公告)日：2021-07-06

申请号：US16619573

申请日：2018-06-12

申请人： UCB BIOPHARMA SRL

发明人： Gareth Neil Brace ,  Rose Elizabeth Chappell ,  Hervé Jean Claude Deboves ,  Anne Marie Foley ,  Gregory Foulkes ,  Elizabeth Pearl Jones ,  Fabien Claude Lecomte ,  Joanna Rachel Quincey ,  Monika-Sarah Elisabeth Dorothea Schulze ,  Matthew Duncan Selby ,  Adam Peter Smalley ,  Richard David Taylor ,  Robert James Townsend ,  Zhaoning Zhu

IPC分类号： C07D471/10 ,  C07D487/10 ,  C07D495/10 ,  C07D491/20 ,  A61K31/4439 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/427 ,  A61K31/433 ,  A61K31/437 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  C07D491/107 ,  C07D519/00

摘要： A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.