公开(公告)号：US11472794B2

公开(公告)日：2022-10-18

申请号：US16959339

申请日：2019-01-10

Applicant: UCB Biopharma SRL

Inventor： Gareth Neil Brace ,  Rose Elizabeth Bardell-Cox ,  Gregory Foulkes ,  James Richard Frost ,  Helen Tracey Horsley ,  Elizabeth Pearl Jones ,  Fabien Claude Lecomte ,  James Thomas Reuberson ,  Monika-Sarah Elizabeth Dorothea Schulze ,  Richard David Taylor ,  Wei Tsung Yau ,  Zhaoning Zhu

IPC: C07D403/12 ,  C07D413/12 ,  C07D407/14 ,  C07D235/16 ,  C07D401/14 ,  C07D413/14

Abstract: A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US12018021B2

公开(公告)日：2024-06-25

申请号：US16973701

申请日：2019-06-20

Applicant: UCB Biopharma SRL

Inventor： Pfrafulkumar Tulshibhai Chovatia ,  Rickki Lee Connelly ,  Richard Jeremy Franklin ,  Gregory William Haslett ,  Alistair James Henry ,  James Madden ,  Judi Charlotte Neuss ,  Timothy John Norman ,  Oliver Philps ,  William Ross Pitt ,  Konstantinos Rampalakos ,  Matthew Duncan Selby ,  Selvaratnam Suganthan ,  Giancarlo Trani ,  Zhaoning Zhu

IPC: C07D409/14 ,  C07D333/50 ,  C07D333/78 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D495/04 ,  C07D495/10 ,  C07D498/10

CPC classification number: C07D409/14 ,  C07D333/50 ,  C07D333/78 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D495/04 ,  C07D495/10 ,  C07D498/10

Abstract: Thiophene derivatives of formula (I) and a pharmaceutically acceptable salt thereof are provided. These compounds have utility for the treatment or prevention of disorders caused by IgE, such as allergy, type 1 hypersensitivity or familiar sinus inflammation.

公开(公告)号：US20230250105A1

公开(公告)日：2023-08-10

申请号：US18175030

申请日：2023-02-27

Applicant: UCB Biopharma SRL ,  SANOFI

Inventor： Daniel Christopher Brookings ,  Teresa De Haro Garcia ,  Yann Foricher ,  Helen Tracey Horsley ,  Martin Clive Hutchings ,  James Andrew Johnson ,  Malcolm Maccoss ,  Mengyang Xuan ,  Zhaoning Zhu

IPC: C07D487/18

CPC classification number: C07D487/18 ,  C07B2200/05

Abstract: A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：US20210252012A1

公开(公告)日：2021-08-19

申请号：US17176018

申请日：2021-02-15

Applicant: UCB Biopharma SRL ,  SANOFI

Inventor： Daniel Christopher Brookings ,  Teresa De Haro Garcia ,  Yann Foricher ,  Helen Tracey Horsley ,  Martin Clive Hutchings ,  James Andrew Johnson ,  Malcolm Maccoss ,  Mengyang Xuan ,  Zhaoning Zhu

IPC: A61K31/55 ,  C07D487/18

Abstract: A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：US20210053952A1

公开(公告)日：2021-02-25

申请号：US16959339

申请日：2019-01-10

Applicant: UCB Biopharma SRL

Inventor： Gareth Neil Brace ,  Rose Elizabeth Chappell ,  Gregory Foulkes ,  James Richard Frost ,  Helen Tracey Horsley ,  Elizabeth Pearl Jones ,  Fabien Claude Lecomte ,  James Thomas Reuberson ,  Monika-Sarah Elizabeth Dorothea Schulze ,  Richard David Taylor ,  Wei Tsung Yau ,  Zhaoning Zhu

IPC: C07D407/14 ,  C07D413/12 ,  C07D413/14 ,  C07D235/16 ,  C07D401/14

Abstract: A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US11912721B2

公开(公告)日：2024-02-27

申请号：US17102790

申请日：2020-11-24

Applicant: UCB Biopharma SRL ,  Sanofi

Inventor： Teresa De Haro Garcia ,  Michael Deligny ,  Jag Paul Heer ,  Joanna Rachel Quincey ,  Mengyang Xuan ,  Zhaoning Zhu ,  Daniel Christopher Brookings ,  Mark Daniel Calmiano ,  Yves Evrard ,  Martin Clive Hutchings ,  James Andrew Johnson ,  Sophie Jadot ,  Jean Keyaerts ,  Malcolm MacCoss ,  Matthew Duncan Selby ,  Michael Alan Shaw ,  Dominique Louis Leon Swinnen ,  Laurent Schio ,  Yann Foricher ,  Bruno Filoche-Romme

IPC: C07D519/00 ,  C07D491/08 ,  C07D487/08 ,  C07D491/18 ,  C07D495/08 ,  C07D471/18 ,  C07D487/18 ,  C07D493/18 ,  C07D495/18 ,  C07D513/18 ,  C07F7/18 ,  A61K31/4184 ,  A61K31/506 ,  A61K31/55

CPC classification number: C07D519/00 ,  A61K31/4184 ,  A61K31/506 ,  A61K31/55 ,  C07D471/18 ,  C07D487/08 ,  C07D487/18 ,  C07D491/08 ,  C07D491/18 ,  C07D493/18 ,  C07D495/08 ,  C07D495/18 ,  C07D513/18 ,  C07F7/1804

Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

公开(公告)号：US20210155637A1

公开(公告)日：2021-05-27

申请号：US17102790

申请日：2020-11-24

Applicant: UCB Biopharma SRL ,  Sanofi

Inventor： Teresa De Haro Garcia ,  Michael Deligny ,  Jag Paul Heer ,  Joanna Rachel Quincey ,  Mengyang Xuan ,  Zhaoning Zhu ,  Daniel Christopher Brookings ,  Mark Daniel Calmiano ,  Yves Evrard ,  Martin Clive Hutchings ,  James Andrew Johnson ,  Sophie Jadot ,  Jean Keyaerts ,  Malcolm Mac Coss ,  Matthew Duncan Selby ,  Michael Alan Shaw ,  Dominique Louis Leon Swinnen ,  Laurent Schio ,  Yann Foricher ,  Bruno Filoche-Romme

IPC: C07D519/00 ,  C07F7/18 ,  C07D491/08 ,  A61K31/4184 ,  A61K31/506 ,  A61K31/55 ,  C07D487/08 ,  C07D491/18 ,  C07D495/08 ,  C07D471/18 ,  C07D487/18 ,  C07D493/18 ,  C07D495/18 ,  C07D513/18

Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

公开(公告)号：US10953019B2

公开(公告)日：2021-03-23

申请号：US16487988

申请日：2018-03-14

Applicant: UCB Biopharma SRL ,  Sanofi

Inventor： Julien Alistair Brown ,  Daniel Christopher Brookings ,  Jag Paul Heer ,  James Andrew Johnson ,  Zhaoning Zhu

IPC: A61K31/55 ,  C07D471/22

Abstract: A series of substituted fused pentacyclic imidazopyridine and imidazopyridazine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：US20220332709A1

公开(公告)日：2022-10-20

申请号：US16973701

申请日：2019-06-20

Applicant: UCB Biopharma SRL

Inventor： Pfrafulkumar Tulshibhai Chovatia ,  Rickki Lee Connelly ,  Richard Jeremy Franklin ,  Gregory William Haslett ,  Alistair James Henry ,  James Madden ,  Judi Charlotte Neuss ,  Timothy John Norman ,  Oliver Philps ,  William Ross Pitt ,  Konstantinos Rampalakos ,  Matthew Duncan Selby ,  Suganthan Selvaratnam ,  Giancarlo Trani ,  Zhaoning Zhu

IPC: C07D409/14 ,  C07D495/04 ,  C07D333/78 ,  C07D333/50 ,  C07D409/12 ,  C07D413/12 ,  C07D487/04 ,  C07D417/12 ,  C07D498/10 ,  C07D409/04 ,  C07D413/04 ,  C07D409/06 ,  C07D495/10

Abstract: Thiophene derivatives of formula (I) and a pharmaceutically acceptable salt thereof are provided. These compounds have utility for the treatment or prevention of disorders caused by IgE, such as allergy, type 1 hypersensitivity or familiar sinus inflammation.

公开(公告)号：US20220242855A1

公开(公告)日：2022-08-04

申请号：US17621877

申请日：2020-06-24

Applicant: UCB Biopharma SRL

Inventor： Shuyu Chu ,  Helen Tracey Horsley ,  James Thomas Reuberson ,  Richard David Taylor ,  Zhaoning Zhu ,  Rose Elizabeth Chappell ,  Gregory William Haslett ,  Adam Peter Smalley ,  Nathaniel Julius Thomas Monck ,  Gareth Neil Brace ,  Prafulkumar Tulshibhai Chovatia

IPC: C07D405/14 ,  C07D487/04 ,  A61K45/06 ,  A61K31/501 ,  A61K31/519 ,  A61K31/4353 ,  C07D498/04 ,  A61K31/4245 ,  A61K31/4439 ,  A61K31/497 ,  C07D417/14

Abstract: A series of substituted fused bicyclic imidazole derivatives of formula (I), including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments including inflammatory and autoimmune disorders, wherein i. a. A represents C—R1 or N; B represents C—R2 or N; D represents C—R3 or N; E represents C—R4 or N; Z represents —CH(R5)N(H)CH2R6, —CH(R5)N(H)S(O)2R6, —C(═CR5aR5b)N(H)C(O)R6, —CH(R5)R7, —CH(R5)N(H)R7 or —CH(R5)C(O)N(H)R7; R0 represents hydrogen or C1-6 alkyl.