公开(公告)号：US11472794B2

公开(公告)日：2022-10-18

申请号：US16959339

申请日：2019-01-10

申请人： UCB Biopharma SRL

发明人： Gareth Neil Brace ,  Rose Elizabeth Bardell-Cox ,  Gregory Foulkes ,  James Richard Frost ,  Helen Tracey Horsley ,  Elizabeth Pearl Jones ,  Fabien Claude Lecomte ,  James Thomas Reuberson ,  Monika-Sarah Elizabeth Dorothea Schulze ,  Richard David Taylor ,  Wei Tsung Yau ,  Zhaoning Zhu

IPC分类号： C07D403/12 ,  C07D413/12 ,  C07D407/14 ,  C07D235/16 ,  C07D401/14 ,  C07D413/14

摘要： A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US20220227764A1

公开(公告)日：2022-07-21

申请号：US17614067

申请日：2020-06-24

申请人： UCB Biopharma SRL

发明人： Anne Marie Foley ,  Fabien Claude Lecomte ,  James Thomas Reuberson ,  Matthew Duncan Selby ,  Richard David Taylor ,  Paul Jonathan Hickford ,  Gareth Neil Brace

IPC分类号： C07D471/04

摘要： A series of substituted fused bicyclic imidazole derivatives, including imidazo[1,2-a]pyridine derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US11052076B2

公开(公告)日：2021-07-06

申请号：US16619573

申请日：2018-06-12

申请人： UCB BIOPHARMA SRL

发明人： Gareth Neil Brace ,  Rose Elizabeth Chappell ,  Hervé Jean Claude Deboves ,  Anne Marie Foley ,  Gregory Foulkes ,  Elizabeth Pearl Jones ,  Fabien Claude Lecomte ,  Joanna Rachel Quincey ,  Monika-Sarah Elisabeth Dorothea Schulze ,  Matthew Duncan Selby ,  Adam Peter Smalley ,  Richard David Taylor ,  Robert James Townsend ,  Zhaoning Zhu

IPC分类号： C07D471/10 ,  C07D487/10 ,  C07D495/10 ,  C07D491/20 ,  A61K31/4439 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/427 ,  A61K31/433 ,  A61K31/437 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  C07D491/107 ,  C07D519/00

摘要： A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US20220073485A1

公开(公告)日：2022-03-10

申请号：US17299137

申请日：2019-11-27

申请人： UCB Biopharma SRL

发明人： Anne Marie Foley ,  Jag Paul Heer ,  Fabien Claude Lecomte ,  Nathaniel Julius Thomas Monck ,  Matthew Duncan Selby ,  Mengyang Xuan ,  Lihu Yang

IPC分类号： C07D309/04 ,  C07D413/14

摘要： A series of functionalised amine derivatives of formula (I) as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US20210228547A1

公开(公告)日：2021-07-29

申请号：US17058973

申请日：2019-07-08

申请人： UCB Biopharma SRL

发明人： Gareth Neil Brace ,  Daniel Christopher Brookings ,  Gregory Foulkes ,  Fabien Claude Lecomte

IPC分类号： A61K31/422 ,  C07D413/12 ,  C07D405/12 ,  C07D491/107 ,  C07D493/10 ,  C07D311/96 ,  C07D491/20 ,  C07D405/14 ,  A61K31/4155 ,  A61K31/427 ,  A61K31/407 ,  A61K31/4245 ,  A61K31/352 ,  A61K31/437

摘要： A series of substituted spirocyclic indane derivatives of Formula (I), and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US11458124B2

公开(公告)日：2022-10-04

申请号：US17058973

申请日：2019-07-08

申请人： UCB Biopharma SRL

发明人： Gareth Neil Brace ,  Daniel Christopher Brookings ,  Gregory Foulkes ,  Fabien Claude Lecomte

IPC分类号： C07D405/14 ,  A61K31/422 ,  A61K31/352 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  C07D311/96 ,  C07D405/12 ,  C07D413/12 ,  C07D491/107 ,  C07D491/20 ,  C07D493/10

摘要： A series of substituted spirocyclic indane derivatives of Formula (I), and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US20210053952A1

公开(公告)日：2021-02-25

申请号：US16959339

申请日：2019-01-10

申请人： UCB Biopharma SRL

发明人： Gareth Neil Brace ,  Rose Elizabeth Chappell ,  Gregory Foulkes ,  James Richard Frost ,  Helen Tracey Horsley ,  Elizabeth Pearl Jones ,  Fabien Claude Lecomte ,  James Thomas Reuberson ,  Monika-Sarah Elizabeth Dorothea Schulze ,  Richard David Taylor ,  Wei Tsung Yau ,  Zhaoning Zhu

IPC分类号： C07D407/14 ,  C07D413/12 ,  C07D413/14 ,  C07D235/16 ,  C07D401/14

摘要： A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US20210380573A1

公开(公告)日：2021-12-09

申请号：US17287861

申请日：2019-11-27

申请人： UCB Biopharma SRL

发明人： Fabien Claude Lecomte ,  Matthew Duncan Selby

IPC分类号： C07D413/14 ,  A61K45/06

摘要： A series of substituted benzimidazol-2-one derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.