公开(公告)号：US20220227764A1

公开(公告)日：2022-07-21

申请号：US17614067

申请日：2020-06-24

Applicant: UCB Biopharma SRL

Inventor： Anne Marie Foley ,  Fabien Claude Lecomte ,  James Thomas Reuberson ,  Matthew Duncan Selby ,  Richard David Taylor ,  Paul Jonathan Hickford ,  Gareth Neil Brace

IPC: C07D471/04

Abstract: A series of substituted fused bicyclic imidazole derivatives, including imidazo[1,2-a]pyridine derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US11052076B2

公开(公告)日：2021-07-06

申请号：US16619573

申请日：2018-06-12

Applicant: UCB BIOPHARMA SRL

Inventor： Gareth Neil Brace ,  Rose Elizabeth Chappell ,  Hervé Jean Claude Deboves ,  Anne Marie Foley ,  Gregory Foulkes ,  Elizabeth Pearl Jones ,  Fabien Claude Lecomte ,  Joanna Rachel Quincey ,  Monika-Sarah Elisabeth Dorothea Schulze ,  Matthew Duncan Selby ,  Adam Peter Smalley ,  Richard David Taylor ,  Robert James Townsend ,  Zhaoning Zhu

IPC: C07D471/10 ,  C07D487/10 ,  C07D495/10 ,  C07D491/20 ,  A61K31/4439 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/427 ,  A61K31/433 ,  A61K31/437 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  C07D491/107 ,  C07D519/00

Abstract: A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US20240140951A1

公开(公告)日：2024-05-02

申请号：US18267235

申请日：2021-12-06

Applicant: UCB Biopharma SRL

Inventor： Gareth Neil Brace ,  Shuyu Chu ,  Anne Marie Foley ,  James Andrew Johnson ,  Timothy John Norman ,  Joanna Rachel Quincey ,  James Thomas Reuberson ,  Robert Straker ,  Robert James Townsend

IPC: C07D487/04 ,  A61P29/00 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61P29/00 ,  C07D519/00

Abstract: A series of substituted imidazo[1,2-b]pyridazine derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US20220073485A1

公开(公告)日：2022-03-10

申请号：US17299137

申请日：2019-11-27

Applicant: UCB Biopharma SRL

Inventor： Anne Marie Foley ,  Jag Paul Heer ,  Fabien Claude Lecomte ,  Nathaniel Julius Thomas Monck ,  Matthew Duncan Selby ,  Mengyang Xuan ,  Lihu Yang

IPC: C07D309/04 ,  C07D413/14

Abstract: A series of functionalised amine derivatives of formula (I) as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.