公开(公告)号：US10134497B2

公开(公告)日：2018-11-20

申请号：US15087111

申请日：2016-03-31

Applicant: UCHICAGO ARGONNE, LLC

Inventor： David A. Ehst ,  James L. Willit

IPC: G21G1/12 ,  G21G1/00 ,  B01D7/00 ,  H05H6/00

Abstract: The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.

公开(公告)号：US11049628B2

公开(公告)日：2021-06-29

申请号：US16166441

申请日：2018-10-22

Applicant: UCHICAGO ARGONNE, LLC

Inventor： David A. Ehst ,  James L. Willit

IPC: G21K5/08 ,  B01D7/00 ,  H05H6/00 ,  G21G1/12 ,  G21G1/00

Abstract: A target unit for producing Cu67 radioisotope is described herein, and comprises a cage body releasably coupled to a screw-on cap; and a ceramic capsule containing a solid Zn68 target ingot and having one open end and one closed end and defining an interior chamber for the target ingot. The ceramic capsule is releasably contained between the cage body and the screw-on cap with a lid disposed on the open end of the capsule and a washer positioned between the lid and the screw-on cap. The screw-on cap and the washer provide a water-tight seal between the lid and the capsule. The interior of the capsule is in intimate physical contact with the target ingot; and the Zn68 of the target ingot is free of traces of residual oxygen that interfere with contact of the Zn68 to the capsule.

公开(公告)号：US20200066418A1

公开(公告)日：2020-02-27

申请号：US16113817

申请日：2018-08-27

Applicant: UCHICAGO ARGONNE, LLC

Inventor： David A. Rotsch ,  Nicholas A. Smith ,  David A. Ehst ,  Sergey A. Chemerisov ,  Jerry A. Nolen, JR. ,  Michael Alexander Brown ,  James J. Grudzinski ,  James L. Bailey ,  Ronald T. Kmak

IPC: G21G1/00 ,  G21G4/08

Abstract: A system for producing and harvesting radioisotopes is provided, the system having a converter housing defining a first beam window; a converter carrier and cartridge in slidable communication with the converter housing; a target housing positioned downstream from the converter housing, the target housing defining a second beam window; and a target carrier in slidable communication with the target housing.

公开(公告)号：US12014838B2

公开(公告)日：2024-06-18

申请号：US16113817

申请日：2018-08-27

Applicant: UCHICAGO ARGONNE, LLC

Inventor： David A. Rotsch ,  Nicholas A. Smith ,  David A. Ehst ,  Sergey A. Chemerisov ,  Jerry A. Nolen, Jr. ,  Michael Alexander Brown ,  James J. Grudzinski ,  James L. Bailey ,  Ronald T. Kmak

IPC: G21G1/12 ,  G21G1/10 ,  G21K5/08

CPC classification number: G21G1/12 ,  G21G1/10 ,  G21K5/08

Abstract: A system for producing and harvesting radioisotopes is provided, the system having a converter housing defining a first beam window; a converter carrier and cartridge in slidable communication with the converter housing; a target housing positioned downstream from the converter housing, the target housing defining a second beam window; and a target carrier in slidable communication with the target housing.