公开(公告)号：US12071653B2

公开(公告)日：2024-08-27

申请号：US17712765

申请日：2022-04-04

Applicant: Ultima Genomics, Inc.

Inventor： Linda Lee ,  Steven Menchen ,  Theo Nikiforov ,  Gilad Almogy ,  Florian Oberstrass

IPC: C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6823 ,  C12Q1/6869 ,  G01N21/64

CPC classification number: C12Q1/6823 ,  C12Q1/6806 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N2021/6439

Abstract: The disclosure provides methods for sequencing nucleic acids using, including with nucleotide analogs and subsequently appended labels.

公开(公告)号：US20240132955A1

公开(公告)日：2024-04-25

申请号：US18475532

申请日：2023-09-27

Applicant: Ultima Genomics, Inc.

Inventor： Linda LEE ,  Theo Nikiforov ,  Alexander Joseph Limardo ,  Maya H. Reamey ,  Steven Menchen ,  Gilad Almogy

IPC: C12Q1/6874 ,  C12Q1/6806 ,  G01N21/64

CPC classification number: C12Q1/6874 ,  C12Q1/6806 ,  G01N21/6486

Abstract: Provided herein are reagents, compositions, and methods for sequencing nucleic acids. Among the reagents disclosed are nucleotides labeled with cleavable linkers. Certain linkers are configured to undergo immolation reactions following cleavage, which can generate scars with enhanced properties for nucleic acid sequencing and synthesis. The present disclosure also provides reagents, compositions, and methods for capping scars generated through linker cleavage, which can alter scar properties, and in some cases can increase the rate and accuracy of nucleotide incorporations during polymerization.

公开(公告)号：US11505820B2

公开(公告)日：2022-11-22

申请号：US16936619

申请日：2020-07-23

Applicant: ULTIMA GENOMICS, INC.

Inventor： Eliane Trepagnier ,  Mark Pratt ,  Theo Nikiforov ,  Gilad Almogy

IPC: C12Q1/6818 ,  C12Q1/6869

Abstract: The present disclosure provides methods and systems for sequencing nucleic acid molecules in a manner that enables higher sequencing accuracy. Methods and systems provided herein may enable sequences that may have low-accuracy reads, such as homopolymer sequences or other repeating sequences, to be determined at a higher accuracy and efficiency.

公开(公告)号：US11326203B2

公开(公告)日：2022-05-10

申请号：US16822121

申请日：2020-03-18

Applicant: Ultima Genomics, Inc.

Inventor： Linda Lee ,  Steven Menchen ,  Theo Nikiforov ,  Gilad Almogy ,  Florian Oberstrass

IPC: C12Q1/68 ,  C12Q1/6823 ,  C12Q1/6806 ,  C12Q1/6869 ,  G01N21/64

Abstract: The disclosure provides methods for sequencing nucleic acids using, including with nucleotide analogs and subsequently appended labels.