公开(公告)号：US20230147683A1

公开(公告)日：2023-05-11

申请号：US17995079

申请日：2021-03-26

申请人： UNION Therapeutics A/S

发明人： Morten SOMMER ,  Rasmus TOFT-KEHLER ,  Anne Katrine TOFT-KEHLER ,  Mads JELLINGSOE ,  Philippe ANDRES

IPC分类号： A61K31/609 ,  A61K47/10 ,  A61K47/22 ,  A61K31/167 ,  A61K9/00 ,  A61P31/14 ,  A61K47/32 ,  A61K47/40 ,  A61K47/20 ,  A61K47/00 ,  A61K9/08

CPC分类号： A61K31/609 ,  A61K47/10 ,  A61K47/22 ,  A61K31/167 ,  A61K9/0078 ,  A61P31/14 ,  A61K47/32 ,  A61K47/40 ,  A61K47/20 ,  A61K47/00 ,  A61K9/08 ,  A61K9/0043

摘要： Inhalable compositions comprising niclosamide, or a pharmaceutically acceptable salt thereof, and polyethylene glycol; aerosols of the compositions; and the pulmonary administrations for use in the treatment of viral infections, for example respiratory viral infections.

公开(公告)号：US20230190685A1

公开(公告)日：2023-06-22

申请号：US17995053

申请日：2021-03-26

申请人： UNION Therapeutics A/S

发明人： Morten SOMMER ,  Rasmus TOFT-KEHLER ,  Anne Katrine TOFT-KEHLER ,  Günter DITZINGER ,  Mads JELLINGSOE ,  Philippe ANDRES ,  Matthias Manne KNOPP

IPC分类号： A61K31/167 ,  A61K31/724 ,  A61K9/10 ,  A61K47/58 ,  A61K9/00 ,  A61P31/14

CPC分类号： A61K31/167 ,  A61K9/10 ,  A61K9/0043 ,  A61K31/724 ,  A61K47/58 ,  A61P31/14

摘要： The invention relates to formulations comprising a halogenated salicylanilide, or a pharmaceutically acceptable salt thereof, and a cyclodextrin. The formulations may be in the form of a liquid formulation, particularly an aqueous formulation, and provide high concentrations of solubilised halogenated salicylanilide. Also disclosed a formulations in the form of powders and aerosols. Also disclosed are the formulations for use in the treatment of bacterial and viral infections, and the treatment of inflammatory diseases. The formulations are particularly suitable for administration by inhalation for the treatment of bacterial and viral pulmonary infections and the treatment of pulmonary inflammatory diseases.