公开(公告)号：US20200080999A1

公开(公告)日：2020-03-12

申请号：US16684532

申请日：2019-11-14

Applicant: UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

Inventor： Joo Hun Kang ,  Se Yong Kwon ,  Min Seok Lee

IPC: G01N33/543 ,  B01L3/00

Abstract: Provided are a method of and apparatus for evaluating immune cells using magnetic particles. According to an aspect of the method, magnetic particles may be used to measure interaction of the magnetic particles with immune cells, thereby diagnosing or evaluating a degree of activation of immune cells of a subject or immune-related diseases of the subject. Further, according to an aspect of the apparatus, a phenomenon of interaction of magnetic particles and activated immune cells via endocytosis may be used to collect magnetic particle-immune cell complexes resulting from the interaction with the magnetic particles by applying a magnetic field, thereby effectively isolating the activated immune cells in a short period of time.

公开(公告)号：US20230149614A1

公开(公告)日：2023-05-18

申请号：US18156965

申请日：2023-01-19

Applicant: UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

Inventor： Joo Hun Kang ,  Se Yong Kwon ,  Bong Hwan Jang ,  Min Seok Lee

IPC: A61M1/34

CPC classification number: A61M1/3406

Abstract: A method of removing harmful substances in blood according to an embodiment of the present disclosure is performed by a fluidic device including an inlet into which isolated blood is injected and at least one blood-clot generating and fixing unit, and the method includes injecting isolated blood into the inlet and removing harmful substances in blood by generating blood clots in the at least one blood-clot generating and fixing unit from the injected blood and fixing the blood clots.

公开(公告)号：US20200261922A1

公开(公告)日：2020-08-20

申请号：US16785396

申请日：2020-02-07

Applicant: UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

Inventor： Joo Hun Kang ,  Se Yong Kwon ,  Ji Eung Oh

IPC: B03C1/32 ,  B03C1/035 ,  G01N33/543

Abstract: One embodiment relates to a system and method by which the magnetic susceptibility of a fluid is changed to separate the fluid according to differences in magnetic susceptibility. According to one embodiment, a fluid separation system and method can efficiently separate materials contained in a fluid according to magnetic susceptibility, without damage such as hemolysis or without changes in the types or concentrations of marker proteins in plasma.

公开(公告)号：US20240286145A1

公开(公告)日：2024-08-29

申请号：US18643136

申请日：2024-04-23

Applicant: UNIST (ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

Inventor： Joo Hun Kang ,  Se Yong Kwon ,  Min Seok Lee

IPC: B03C1/32 ,  B03C1/01

CPC classification number: B03C1/32 ,  B03C1/01 ,  B03C2201/20

Abstract: Provided are a method of and apparatus for evaluating immune cells using magnetic particles. According to an aspect of the method, magnetic particles may be used to measure interaction of the magnetic particles with immune cells, thereby diagnosing or evaluating a degree of activation of immune cells of a subject or immune-related diseases of the subject. Further, according to an aspect of the apparatus, a phenomenon of interaction of magnetic particles and activated immune cells via endocytosis may be used to collect magnetic particle-immune cell complexes resulting from the interaction with the magnetic particles by applying a magnetic field, thereby effectively isolating the activated immune cells in a short period of time.

公开(公告)号：US20240174962A1

公开(公告)日：2024-05-30

申请号：US18551788

申请日：2022-03-24

Applicant: UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

Inventor： Joo Hun Kang ,  Brian Choi ,  Jeongwon Choi ,  Tae-eun Park

IPC: C12M1/00 ,  C12M1/26 ,  C12M3/06

CPC classification number: C12M29/04 ,  C12M23/16 ,  C12M23/20 ,  C12M33/04 ,  C12M33/14

Abstract: The disclosure relates to a functional membrane, a microfluidic chip including the same, and a method of manufacturing the microfluidic chip. The functional membrane according to an embodiment includes a membrane having one or more pores, and a coating material covering the pores, on at least one surface of the membrane.

公开(公告)号：US20220072047A1

公开(公告)日：2022-03-10

申请号：US17012614

申请日：2020-09-04

Applicant: UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

Inventor： Joo Hun Kang ,  Seyong Kwon

IPC: A61K35/18 ,  A61K47/69 ,  A61K47/52 ,  A61P31/04 ,  A61P31/12 ,  A61P39/00 ,  A61K47/02 ,  G01N33/543 ,  A61M1/16 ,  A61M1/36

Abstract: Provided are magnetic immunoparticles and use thereof, specifically, magnetic immunoparticles including a cell membrane capable of capturing a pathogenic material and magnetic particles attached to the cell membrane, a method of detecting pathogenic materials using the magnetic immunoparticles, and a method of diagnosing and treating an infectious disease using the magnetic immunoparticles. The magnetic immunoparticles according to an aspect may include cell membranes capable of capturing pathogenic materials, and thus may minimize side effects in vivo, and may detect various kinds of pathogenic materials due to characteristics of the cells from which the cell membranes are derived. Further, since the magnetic immunoparticles include magnetic particles, the magnetic immunoparticles may be easily separated by applying a magnetic field, and thus pathogenic materials may be more effectively detected and removed.