公开(公告)号：US20180024343A1

公开(公告)日：2018-01-25

申请号：US15539320

申请日：2015-12-16

申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS ,  ISERM (INSTITUT NATIONAL DE LA SANTE ET LA RECHERCHE MEDICALE) ,  UNIVERSITE PARIS-SUD ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS - APHP

发明人： Guillaume CHENEGROS ,  Ryad BENOSMAN ,  Nicolas LIBERT ,  Jacques DURENTEAU ,  Anatole HARROIS ,  Serge PICAUD ,  Jose-Alain SAHEL

IPC分类号： G02B21/36 ,  A61B5/026 ,  G02B21/06 ,  G01N21/53

CPC分类号： G02B21/361 ,  A61B5/0077 ,  A61B5/0261 ,  A61B5/14556 ,  A61B5/7285 ,  G01N21/474 ,  G01N21/53 ,  G01N2021/4709 ,  G01N2021/4759 ,  G01N2201/06113 ,  G01N2201/062 ,  G02B21/06

摘要： Disclosed is an imaging device including a light source arranged so as to generate an optical signal, an optical support coupled to the light source and arranged so as to project a luminous excitation signal with a substantially constant light intensity, from the light source to a body to be observed during the use of the device, and an asynchronous camera coupled to the optical support and designed so as to generate a signal including, for each pixel of a first pixel matrix, a signal sequence representing asynchronous events corresponding to variations of the light backscattered by the body to be observed for the pixel.

公开(公告)号：US20170111619A1

公开(公告)日：2017-04-20

申请号：US15128996

申请日：2015-03-12

申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS

发明人： Ryad BENOSMAN ,  Guillaume CHENEGROS ,  Serge PICAUD ,  Siohoi IENG ,  Jose-Alain SAHEL

IPC分类号： H04N9/31 ,  A61N1/05 ,  A61N1/36 ,  G02B26/08 ,  G02C11/00

CPC分类号： H04N9/312 ,  A61B5/6821 ,  A61N1/0543 ,  A61N1/36046 ,  G02B26/0833 ,  G02B27/017 ,  G02B27/18 ,  G02B2027/0118 ,  G02B2027/014 ,  G02B2027/0178 ,  G02C11/10

摘要： A device for displaying an image sequence in the form of a pixel matrix, includes a control unit coupled to a projector. The control unit includes an input interface designed to receive asynchronous information representing, for each pixel of the matrix, events concerning the pixel, and a processor designed to control the activation of each pixel of the matrix at moments determined by the respective events indicated by the asynchronous information for the pixel. The projector is disposed on a support so as to illuminate the light receptors of the eye when the device is in use and is designed to project a light flux corresponding to the pixels activated by the control unit.

公开(公告)号：US20210308169A1

公开(公告)日：2021-10-07

申请号：US15865354

申请日：2018-01-09

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  Universite Pierre et Marie Curie (Paris 6) ,  Centre National de la Recherche Scientifique (CNRS)

发明人： Jose-Alain SAHEL ,  Serge PICAUD ,  Thierry LEVEILLARD ,  Deniz DALKARA ,  Jens DUEBEL ,  Botond ROSKA

IPC分类号： A61K31/7088 ,  A61K38/16 ,  C07K14/47 ,  C07K14/215 ,  A61K38/17

摘要： The present invention relates to an isolated nucleic acid molecule comprising i) a nucleotide sequence coding for a hyperpolarizing light-gated ion channel or pump gene from an archeon or for a light-active fragment of said gene, or the nucleotide sequence and ii) a nucleotide sequence coding for a neurotrophic factor for use in the treatment of a retinal degenerative disease.

公开(公告)号：US20160213701A1

公开(公告)日：2016-07-28

申请号：US15092129

申请日：2016-04-06

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  Universite Pierre et Marie Curie (Paris 6) ,  Centre National de la Recherche Scientifique (CNRS)

发明人： Jose-Alain SAHEL ,  Serge PICAUD ,  Thierry LEVEILLARD ,  Deniz DALKARA ,  Jens DUEBEL ,  Botond ROSKA

IPC分类号： A61K31/7088

CPC分类号： A61K31/7088 ,  A61K38/16 ,  A61K38/164 ,  A61K38/1709 ,  A61K48/00 ,  C07K14/215 ,  C07K14/47 ,  Y02A50/465 ,  A61K2300/00

摘要： The present invention relates to an isolated nucleic acid molecule comprising i) a nucleotide sequence coding for a hyperpolarizing light-gated ion channel or pump gene from an archeon or for a light-active fragment of said gene, or the nucleotide sequence and ii) a nucleotide sequence coding for a neurotrophic factor for use in the treatment of a retinal degenerative disease.

公开(公告)号：US20150343202A1

公开(公告)日：2015-12-03

申请号：US14655021

申请日：2013-12-24

申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Serge PICAUD ,  Amel BENDALI ,  Philippe BERGONZO ,  Valerie FOSTER-FRADOT ,  Jose-Alain SAHEL

IPC分类号： A61N1/05

CPC分类号： A61N1/0526 ,  A61N1/05 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/36036 ,  A61N1/36046 ,  B82Y5/00

摘要： A biocompatible carbon based electrode, and its preparation process are described. The electrode is formed by first and second biocompatible chemically oxygen terminated or H-terminated carbon-based materials. The first material is configured to promote the growth or at least the direct interfacing of adult neurons on the first material without substantially promoting the growth and direct interfacing of glial cells on the first material. The second material presents a peptide coating to promote the growth and at least the direct interfacing of adult glial cells.

摘要翻译： 描述了一种生物相容性碳基电极及其制备方法。 电极由第一和第二生物相容的化学氧封端或H封端的碳基材料形成。 第一材料被配置成促进成体神经元在第一材料上的生长或至少直接接合，而基本上不促进胶质细胞在第一材料上的生长和直接接合。 第二种材料呈现肽包被促进成长胶原细胞的生长和至少直接接合。

公开(公告)号：US20190269755A1

公开(公告)日：2019-09-05

申请号：US16097204

申请日：2017-04-28

申请人： Gensight Biologics SA ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSITITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICALE

发明人： Didier PRUNEAU ,  Anne DOUAR ,  Deniz DALKARA ,  Jens DUEBEL ,  Romain CAPLETTE ,  Gregory GAUVAIN ,  Melissa DESROSIERS ,  Jose SAHEL ,  Serge PICAUD

IPC分类号： A61K38/17 ,  A61K38/16 ,  A61K35/761 ,  A61K9/00 ,  A61P27/02

摘要： Disclosed are, among other methods, methods for reactivating retinal ganglion cells in mammals by administering an effective amount of channelrhodopsins (such as ChrimsonR), or an effective amount of such channelrhodopsins (such as ChrimsonR) fused to a fluorescent protein, in the form of protein or nucleic acids, and compositions thereof. The methods may include a light stimuli level inducing RGCs response that is below radiation safety limit. The methods may include delivery by an adenoassociated virus vector. The methods may include use of a CAG promoter. The methods may result in a long term expression of an effective amount of the channelrhodopsins (such as ChrimsonR protein).