公开(公告)号：US20240319213A1

公开(公告)日：2024-09-26

申请号：US18694171

申请日：2022-09-26

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Shafique Keshavjee ,  Andrew Sage ,  Marcelo Cypel ,  Tereza Martinu

IPC: G01N33/92 ,  G01N33/543 ,  G01N33/68

CPC classification number: G01N33/92 ,  G01N33/54388 ,  G01N33/6869 ,  G01N33/6893 ,  G01N2333/521 ,  G01N2333/5412 ,  G01N2333/5421 ,  G01N2800/06 ,  G01N2800/24 ,  G01N2800/50

Abstract: Methods, kits and devices for assessing bile acid in a donor lung and/or a transplant recipient are described. The methods involve obtaining from the donor lung or transplant recipient a bronchial wash sample, optionally a bronchoalveolar lavage (BAL) sample or a large airway bronchial wash (LABW) sample; measuring in the bronchial wash sample the level of bile acid and optionally one or more inflammation markers, comparing biomarker levels with a control or cut-off level, wherein a differential biomarker level is indicative of an outcome of the donor lung or transplant recipient, including risk of aspiration, suitability of the donor lung, or risk of a particular outcome in the transplant recipient.