-
公开(公告)号：US20240319213A1
公开(公告)日：2024-09-26
申请号：US18694171
申请日：2022-09-26
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Shafique Keshavjee , Andrew Sage , Marcelo Cypel , Tereza Martinu
IPC: G01N33/92 , G01N33/543 , G01N33/68
CPC classification number: G01N33/92 , G01N33/54388 , G01N33/6869 , G01N33/6893 , G01N2333/521 , G01N2333/5412 , G01N2333/5421 , G01N2800/06 , G01N2800/24 , G01N2800/50
Abstract: Methods, kits and devices for assessing bile acid in a donor lung and/or a transplant recipient are described. The methods involve obtaining from the donor lung or transplant recipient a bronchial wash sample, optionally a bronchoalveolar lavage (BAL) sample or a large airway bronchial wash (LABW) sample; measuring in the bronchial wash sample the level of bile acid and optionally one or more inflammation markers, comparing biomarker levels with a control or cut-off level, wherein a differential biomarker level is indicative of an outcome of the donor lung or transplant recipient, including risk of aspiration, suitability of the donor lung, or risk of a particular outcome in the transplant recipient.
-
公开(公告)号：US12207651B2
公开(公告)日：2025-01-28
申请号：US16500657
申请日：2018-03-29
Applicant: University Health Network , Universidade de São Paulo
Inventor： Vanderlei Salvador Bagnato , Marcelo Cypel , Shafique Keshavjee , Thomas Kenneth Waddell , Marcos Theophilo Galasso
Abstract: Disclosed are apparatuses and methods for irradiating a perfusate. The apparatus includes a tank which defines a first chamber. A separator is located inside the first chamber. The separator defines a second chamber. The first chamber and the second chamber are concentric and have substantially annular cross sections, each having at least one diameter and a substantially common longitudinal axis. A perfusate is introduced into the first chamber by an inlet. A UV radiation-emitting device is disposed inside the second chamber for providing irradiation to the perfusate. Irradiated perfusate is removed from the tank by an outlet. Other apparatuses and systems are described and methods for inactivating micro organisms by performing EVP and irradiating the perfusate.
-
公开(公告)号：US20240251783A1
公开(公告)日：2024-08-01
申请号：US18565387
申请日：2022-03-08
Applicant: University Health Network
Inventor： Mingyao Liu , Shafique Keshavjee , Marcelo Cypel
IPC: A01N1/02
CPC classification number: A01N1/0226 , A01N1/0284
Abstract: Provided is a lung preservation composition comprising a non-carbonic buffered nutrient media, preferably a phosphate buffered nutrient media, and a dextran, optionally Dextran 40 and and optionally prostaglandin E1 (PGE1), and optionally at least one of alpha 1 antitrypsin (A1AT), an impermeant, optionally raffinose, an antioxidant, optionally glutathione, and necrostatin-1. Also described is a method of preserving a lung prior to and/or during transplant using said lung preservation composition, and kits comprising one or more components of the lung preservation composition.
-
公开(公告)号：US20220181020A1
公开(公告)日：2022-06-09
申请号：US17598179
申请日：2020-03-27
Applicant: University Health Network
Inventor： Shafique Keshavjee , Marijana Zubrinic , Lukasz Brzozowski , Xun Lin , Zigang Jimmy Qiu , An Wang
IPC: G16H40/67 , G16H40/20 , G16H50/20 , A61B5/11 , A61B5/00 , G06V20/52 , G06V10/25 , G06V10/28 , G06V10/44 , G06V10/70 , H04N5/232 , G06F3/01 , G06F40/58
Abstract: A system and method for providing and managing a remote patient monitoring (RPM) system. The method is implemented by a central server, an RPM client, and a networked monitoring device. The RPM client is a software program that is executed by a computing device that is connected to the server via a network. The networked monitoring device is implemented as a locator or a smart mobile cart. More specifically, the RPM system can provide a tele-monitor with the ability to remotely monitor multiple patients, control remote cameras, and address abnormal patient situations. The RPM system can enhance tele-monitor effectiveness by detecting patient motion and tracking tele-monitor alertness.
-
公开(公告)号：US20230384186A1
公开(公告)日：2023-11-30
申请号：US18034278
申请日：2021-10-28
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Kieran Murphy , Diana Vucevic , Shafique Keshavjee
IPC: G01N1/30 , C12Q1/6806 , G01N1/31
CPC classification number: G01N1/30 , C12Q1/6806 , G01N1/31 , G01N2001/302 , G01N2001/305
Abstract: Provided is a fixative composition comprising from at least 5 percent to 50 percent syrup, optionally honey, preferably, at least 10 syrup, and dextran and optionally coconut oil, optionally from at least 10 g/L to about 60 g/L of dextran, preferably about 50 g/L and/or from at least 0.5 percent to 15 percent coconut oil, preferably at least 1 percent coconut oil, methods of making the solution, methods of using the solution, for example methods for preserving a biological sample in said solution, and containers and kits comprising the solution.
-
Patent Agency Ranking
公开(公告)号：US20230100616A1
公开(公告)日：2023-03-30
申请号：US17911208
申请日：2021-03-15
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Andrew Sage , Jerome Valero , Lorenzo Del Sorbo , Marcelo Cypel , Bo Wang , Shafique Keshavjee
Abstract: Methods and kits for screening, diagnosing, detecting or predicting a patient outcome/risk in a patient with a respiratory illness, the method comprising: a. obtaining a sample obtained from the patient; b. quantitatively measuring in the sample a polypeptide level of one or more biomarkers selected from: IL-6, CXCL8, IL-10, IL-IRA, IL-2, IL-4, IL-7, IL-9, IL-13, IL-17, IFN-g, IP-10, MCP-1, G-CSF, GM-CSF, FGF-basic, SCGF-β, GRO-α, MIP1-α, MIP1-β, CK-18, PDGF-bb, caspase 3, HMGB-1, TNF α, VEGF, sTNFR1 and sTREM1; and c. i) comparing the level of the one or more biomarkers in the sample with a control or cut-off level, wherein the differential level is indicative of patient outcome risk; or ii) using the polypeptide level of several of the biomarkers in combination, as inputs for an algebraic calculation or machine learning model of patient outcome risk.
-
公开(公告)号：US11045633B2
公开(公告)日：2021-06-29
申请号：US15302751
申请日：2015-04-10
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Daniel Gavin Harrison , Geoffrey Samuel Frost , Thomas Kenneth Waddell , Laura Ann Wyvill , Raymond Francis Cracauer , Shafique Keshavjee , Marcelo Cypel , Randy Yang
Abstract: A cannula for connecting a medical device to a biological system is taught. The cannula includes a tissue engagement portion, preferably in the form of an annulus, to which a vacuum is applied through the cannula to attract and hold tissue of the biological system in an initial connection while an affixment device is applied to complete the connection. In addition to a working fluid conduit, comprising a main port, a working fluid passage and a working fluid port, and a port to apply the vacuum, the cannula can include a sensor port to allow sensing pressure or other characteristics of the working fluid at a point closely adjacent to the connection between the cannula and the biological system.
-
公开(公告)号：US20220341944A1
公开(公告)日：2022-10-27
申请号：US17413772
申请日：2019-12-13
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Shafique Keshavjee , Mingyao Liu , Marcelo Cypel , Andrew Sage
Abstract: Methods and kits for screening, diagnosing, detecting or predicting a patient outcome/risk variable for a lung transplant recipient after transplant or an EVLP outcome by measuring biomarker levels of at least three biomarkers selected from IL-6, IL-8, IL-10 and IL-1β optionally in combination with one or both of sTNFR1 and sTREM1 in EVLP perfusate are described. The methods involve for example, i. obtaining one or more test EVLP perfusate samples of a donor lung; ii. determining in one or more test EVLP perfusate sample of a donor lung, a polypeptide level of the at least three biomarkers selected from IL-8, IL-6, IL-10 and IL-1β and optionally one or both of sTNFR1 and sTREM1 i; and iii. a) comparing the one or more parameter values related to a level of the at least three biomarkers in the perfusate sample with control EVLP data or a cut-off level, wherein the differential level is indicative of outcome/risk of after transplant or of an EVLP outcome; or b) using the one or more parameter values related to a level of the at least three biomarkers in combination, as part of an algebraic calculation or model of outcome/risk.
-
公开(公告)号：US20200253195A1
公开(公告)日：2020-08-13
申请号：US16500657
申请日：2018-03-29
Applicant: Vanderlei Salvador Bagnato , University Health Network
Inventor： Vanderlei Salvador Bagnato , Marcelo Cypel , Shafique Keshavjee , Thomas Kenneth Waddell , Marcos Theophilo Galasso
Abstract: Disclosed are apparatuses and methods for irradiating a perfusate. The apparatus includes a tank which defines a first chamber. A separator is located inside the first chamber. The separator defines a second chamber. The first chamber and the second chamber are concentric and have substantially annular cross sections, each having at least one diameter and a substantially common longitudinal axis. A perfusate is introduced into the first chamber by an inlet. A UV radiation-emitting device is disposed inside the second chamber for providing irradiation to the perfusate. Irradiated perfusate is removed from the tank by an outlet. Other apparatuses and systems are described and methods for inactivating micro organisms by performing EVP and irradiating the perfusate.
-
公开(公告)号：US20170036006A1
公开(公告)日：2017-02-09
申请号：US15302751
申请日：2015-04-10
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Daniel Gavin Harrison , Geoffrey Samuel Frost , Thomas Kenneth Waddell , Laura Ann Wyvill , Raymond Francis Cracauer , Shafique Keshavjee , Marcelo Cypel , Randy Yang
CPC classification number: A61M39/0247 , A01N1/0247 , A61M2039/0258 , A61M2039/0261 , A61M2039/0264 , A61M2039/0273 , A61M2039/0276
Abstract: A cannula for connecting a medical device to a biological system is taught. The cannula includes a tissue engagement portion, preferably in the form of an annulus, to which a vacuum is applied through the cannula to attract and hold tissue of the biological system in an initial connection while an affixment device is applied to complete the connection. In addition to a working fluid conduit, comprising a main port, a working fluid passage and a working fluid port, and a port to apply the vacuum, the cannula can include a sensor port to allow sensing pressure or other characteristics of the working fluid at a point closely adjacent to the connection between the cannula and the biological system.
Abstract translation: 教导了用于将医疗装置连接到生物系统的套管。 套管包括优选为环形的组织接合部分，当施加固定装置以完成连接时，真空通过套管施加真空以在初始连接中吸引和保持生物系统的组织。 除了包括主端口，工作流体通道和工作流体端口以及施加真空的端口的工作流体导管之外，套管还可以包括传感器端口，以允许感测工作流体的压力或其它特性 与插管和生物系统之间的连接紧密相邻的点。
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.018 seconds)
