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    Oxidase activity of polymeric coated cerium oxide nano-particles
    3.
    发明授权
    Oxidase activity of polymeric coated cerium oxide nano-particles 有权

    公开(公告)号：US11307199B2

    公开(公告)日：2022-04-19

    申请号：US16358049

    申请日：2019-03-19

    申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

    发明人： Jesus Manuel Perez ,  Atul Asati ,  Santimukul Santra ,  Charalambos Kaittanis ,  Sudip Nath

    IPC分类号： G01N33/543 ,  G01N33/94 ,  B82Y15/00 ,  B01J31/26 ,  G01N33/574 ,  G01N33/58

    摘要： Methods, systems, compositions include biocompatible polymer coated nanoceria that function as aqueous redox catalyst with enhanced activity at an acidic to moderately alkaline pH value between 1 and 8. The compositions are used as oxidizing agents for decomposition, decontamination or inactivation of organic contaminants, such as, pesticides and chemical warfare agents. Another use includes nanoceria as targetable nanocatalyst prepared by conjugating various targeting ligands to the nanoparticle coating to form a colorimetric or fluorescent probe in immunoassays and other molecule binding assays that involve the use of a molecule in solution that changes the color of the solution or emits a fluorescent signal, where localization of nanoceria to organs or tissue is assessed by treatment with an oxidation sensitive dye or other detection devices. Versatility and uses of the nanoceria compositions are controlled by pH value, choice of dye substrate and thickness of the polymer coating on the ceria nanoparticles.

    DIFFERENTIAL TUMOR CELL CYTOTOXICITY VIA CONTACT WITH COATED CERIUM OXIDE NANOPARTICLES
    4.
    发明申请
    DIFFERENTIAL TUMOR CELL CYTOTOXICITY VIA CONTACT WITH COATED CERIUM OXIDE NANOPARTICLES 审中-公开

    公开(公告)号：US20190255101A1

    公开(公告)日：2019-08-22

    申请号：US16284784

    申请日：2019-02-25

    申请人： University of Central Florida Research Foundation, Inc.

    发明人： Jesus Manuel Perez ,  Atul Asati ,  Santimukul Santra ,  Charalambos Kaittanis

    IPC分类号： A61K33/24 ,  A61K9/51

    摘要： Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines. In contrast, minimal toxicity is observed when they localize into the cytoplasm or do not enter the cells.

    Oxidase activity of polymeric coated cerium oxide nano-particles
    5.
    发明授权
    Oxidase activity of polymeric coated cerium oxide nano-particles 有权

    公开(公告)号：US10261074B1

    公开(公告)日：2019-04-16

    申请号：US14537102

    申请日：2014-11-10

    申请人： University of Central Florida Research Foundation, Inc.

    发明人： Jesus Manuel Perez ,  Atul Asati ,  Santimukul Santra ,  Charalambos Kaittanis ,  Sudip Nath

    IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/58 ,  G01N33/574 ,  B01J31/26

    摘要： Methods, systems, compositions include biocompatible polymer coated nanoceria that function as aqueous redox catalyst with enhanced activity at an acidic to moderately alkaline pH value between 1 and 8. The compositions are used as oxidizing agents for decomposition, decontamination or inactivation of organic contaminants, such as, pesticides and chemical warfare agents. Another use includes nanoceria as targetable nanocatalyst prepared by conjugating various targeting ligands to the nanoparticle coating to form a colorimetric or fluorescent probe in immunoassays and other molecule binding assays that involve the use of a molecule in solution that changes the color of the solution or emits a fluorescent signal, where localization of nanoceria to organs or tissue is assessed by treatment with an oxidation sensitive dye or other detection devices. Versatility and uses of the nanoceria compositions are controlled by pH value, choice of dye substrate and thickness of the polymer coating on the ceria nanoparticles.