公开(公告)号：US20140127675A1

公开(公告)日：2014-05-08

申请号：US14148945

申请日：2014-01-07

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： FAN REN ,  STEPHEN JOHN PEARTON ,  TANMAY P. LELE

IPC: G01N27/327

CPC classification number: G01N27/3275 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/56911 ,  G01N33/56983 ,  G01N2333/33

Abstract: Embodiments of the present invention provide binding molecule-functionalized high electron mobility transistors (HEMTs) that can be used to detect toxins, pathogens and other biological materials. In a specific embodiment, an antibody-functionalized HEMT can be used to detect botulinum toxin. The antibody can be anchored to a gold-layered gate area of theHEMT through immobilized thioglycolic acid. Embodiments of the subject detectors can be used in field-deployable electronic biological applications based on AlGaN/GaN HEMTs.

Abstract translation: 本发明的实施方案提供可用于检测毒素，病原体和其他生物材料的结合分子官能化的高电子迁移率晶体管（HEMT）。 在具体实施方案中，抗体功能化的HEMT可用于检测肉毒杆菌毒素。 抗体可以通过固定化的巯基乙酸锚定在HEMT的金层门区。 本发明的检测器的实施例可以用于基于AlGaN / GaN HEMT的现场可部署电子生物学应用中。