公开(公告)号：US20180325780A1

公开(公告)日：2018-11-15

申请号：US15772345

申请日：2016-10-28

Applicant: University of Florida Research Foundation, Inc.

Inventor： JOSEPHINE F. ESQUIVEL-UPSHAW ,  FAN REN ,  ARTHUR E. CLARK

IPC: A61K6/00 ,  A61K6/027

Abstract: Dental prosthetic restoration coatings made of dielectric materials, methods of fabricating the same, as well as methods of testing dental prosthetic restorations are provided. A prosthetic restoration coating can include dielectric materials such as Al2O3, ZrO2, SiNx, SiC, and SiO2. Application can take place using plasma enhanced chemical vapor deposition (PECVD) methods, and alternating materials can be used to achieve desired anticorrosive, structural integrity, hardness, adhesion, and color characteristics. A testing method can include immersing a test device in solutions of differing pH, with or without abrasive steps. The cycling can include an acidic solution and a basic solution, with an optional neutral solution. As the abrasive step, a chewing simulator can be utilized.

公开(公告)号：US20160175243A1

公开(公告)日：2016-06-23

申请号：US14591729

申请日：2015-01-07

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： TANMAY P. LELE ,  FAN REN ,  BENJAMIN G. KESELOWSKY ,  JIYEON LEE ,  ANAND GUPTE ,  BYUNG-HWAN CHU ,  KARL R. ZAWOY

IPC: A61K9/00 ,  A61K38/02 ,  A61K31/366 ,  A61K33/24 ,  A61K38/48 ,  C01G9/02 ,  A61K31/407

CPC classification number: A61K9/00 ,  A61K31/366 ,  A61K31/407 ,  A61K33/24 ,  A61K38/02 ,  A61K38/4893 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01G9/02 ,  C01G23/047 ,  C01P2004/03 ,  C01P2004/16 ,  C01P2004/62 ,  C01P2004/64 ,  C12Y304/24069 ,  C30B7/10 ,  C30B29/16 ,  C30B29/60 ,  Y10S977/762 ,  Y10S977/915 ,  Y10T428/249924 ,  Y10T428/249925 ,  Y10T428/24994 ,  Y10T428/294 ,  Y10T428/2958 ,  Y10T428/2964 ,  Y10T428/298

Abstract: The subject invention concerns nanorods, compositions and substrates comprising nanorods, and methods of making and using nanorods and nanorod compositions and substrates. In one embodiment, the nanorod is composed of Zinc oxide (ZnO). In a further embodiment, a nanorod of the invention further comprises SiO2 or TiO2. In a specific embodiment, a nanorod of the invention is composed of ZnO coated with SiO2. Nanorods of the present invention are useful as an adhesion-resistant biomaterial capable of reducing viability in anchorage-dependent cells.

Abstract translation: 本发明涉及包含纳米棒的纳米棒，组合物和底物，以及制备和使用纳米棒和纳米棒组合物和底物的方法。 在一个实施方案中，纳米棒由氧化锌（ZnO）组成。 在另一个实施方案中，本发明的纳米棒还包含SiO 2或TiO 2。 在具体实施方案中，本发明的纳米棒由涂覆有SiO 2的ZnO组成。 本发明的纳米棒可用作能够降低锚定依赖性细胞活力的耐粘附生物材料。

公开(公告)号：US20140127675A1

公开(公告)日：2014-05-08

申请号：US14148945

申请日：2014-01-07

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： FAN REN ,  STEPHEN JOHN PEARTON ,  TANMAY P. LELE

IPC: G01N27/327

CPC classification number: G01N27/3275 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/56911 ,  G01N33/56983 ,  G01N2333/33

Abstract: Embodiments of the present invention provide binding molecule-functionalized high electron mobility transistors (HEMTs) that can be used to detect toxins, pathogens and other biological materials. In a specific embodiment, an antibody-functionalized HEMT can be used to detect botulinum toxin. The antibody can be anchored to a gold-layered gate area of theHEMT through immobilized thioglycolic acid. Embodiments of the subject detectors can be used in field-deployable electronic biological applications based on AlGaN/GaN HEMTs.

Abstract translation: 本发明的实施方案提供可用于检测毒素，病原体和其他生物材料的结合分子官能化的高电子迁移率晶体管（HEMT）。 在具体实施方案中，抗体功能化的HEMT可用于检测肉毒杆菌毒素。 抗体可以通过固定化的巯基乙酸锚定在HEMT的金层门区。 本发明的检测器的实施例可以用于基于AlGaN / GaN HEMT的现场可部署电子生物学应用中。