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公开(公告)号：US11975061B2
公开(公告)日：2024-05-07
申请号：US17273801
申请日：2019-09-05
Inventor： Roy Curtiss, III
CPC classification number: A61K39/098 , A61K2039/522 , A61K2039/523 , A61K2039/70
Abstract: Bacterial pathogens have evolved means to succeed as pathogens by infecting without recognition by receptors triggering innate immunity, by suppressing induction of immunity and by inducing immune responses to antigens that confer no protectives immunity. Embodiments described herein circumvent these abilities in Salmonella so as to provide a vector system that induces maximal protective immune responses. Another major problem in using live attenuated bacterial vaccine vectors is the accumulation of attenuating mutations that confer a virulence and safety but which decrease the ability of the vaccine to invade cells in the MALT to colonize and persist in internal effector lymphoid tissues. The embodiments disclosed herein solve this problem in multiple ways by using regulated delayed in vivo shut off of virulence genes, regulated delayed synthesis of recombinant protective antigens and regulated delayed lysis in vivo to confer biological containment with no persistence of vaccine cells and no survival if excreted.
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公开(公告)号：US20200368339A1
公开(公告)日：2020-11-26
申请号：US16636251
申请日：2018-08-03
Inventor： Roy Curtiss, III , Shifeng Wang
Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens from Clostridium Perfringens as vaccines to prevent necrotic enteritis (NE).
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公开(公告)号：US11969468B2
公开(公告)日：2024-04-30
申请号：US17291480
申请日：2019-11-04
Inventor： Roy Curtiss, III
CPC classification number: A61K39/39 , A61K35/74 , A61K39/04 , A61P37/04 , A61K2039/522 , A61K2039/523 , A61K2039/55594
Abstract: Disclosed herein are unique adjuvant compositions comprising an attenuated derivative of a bacterial pathogen that undergoes lysis in vivo. In exemplary embodiments, the bacterial pathogen is a Salmonella spp. Also disclosed are methods for enhancing an immune response using the adjuvants disclosed herein.
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公开(公告)号：US11788056B2
公开(公告)日：2023-10-17
申请号：US17213619
申请日：2021-03-26
Inventor： Roy Curtiss, III , Shifeng Wang
CPC classification number: C12N1/36 , A61K39/0275 , A61K39/08 , A61P31/04 , C12N15/74 , A61K2039/522 , A61K2039/523 , A61K2039/542
Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
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公开(公告)号：US20210283235A1
公开(公告)日：2021-09-16
申请号：US17207948
申请日：2021-03-22
Inventor： Roy Curtiss, III , Soo-Young Wanda
IPC: A61K39/112 , A61K39/02 , A61K39/205 , C07K14/205 , C12N1/36 , C12N15/74
Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.
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Patent Agency Ranking
公开(公告)号：US11766475B2
公开(公告)日：2023-09-26
申请号：US17207948
申请日：2021-03-22
Inventor： Roy Curtiss, III , Soo-Young Wanda
IPC: A61K39/02 , A61K39/112 , A61K39/205 , C07K14/205 , C12N1/36 , C12N15/74 , A61K39/00
CPC classification number: A61K39/0275 , A61K39/105 , A61K39/205 , C07K14/205 , C12N1/36 , C12N15/74 , A61K2039/522 , A61K2039/523 , A61K2039/58 , A61K2039/70
Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.
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公开(公告)号：US11596677B2
公开(公告)日：2023-03-07
申请号：US16636251
申请日：2018-08-03
Inventor： Roy Curtiss, III , Shifeng Wang
Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens from Clostridium Perfringens as vaccines to prevent necrotic enteritis (NE).
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公开(公告)号：US20210284955A1
公开(公告)日：2021-09-16
申请号：US17213619
申请日：2021-03-26
Inventor： Roy Curtiss, III , Shifeng Wang
IPC: C12N1/36 , A61P31/04 , A61K39/112 , A61K39/08 , C12N15/74
Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
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公开(公告)号：US10988729B2
公开(公告)日：2021-04-27
申请号：US16480253
申请日：2018-01-23
Inventor： Roy Curtiss, III , Shifeng Wang
Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
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10.发明申请公开(公告)号：US20200009240A1
公开(公告)日：2020-01-09
申请号：US16480904
申请日：2018-01-26
Inventor： Roy Curtiss, III , Soo-Young Wanda
IPC: A61K39/112 , A61K39/02 , A61K39/205 , C07K14/205 , C12N1/36 , C12N15/74
Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.
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