公开(公告)号：US11911521B2

公开(公告)日：2024-02-27

申请号：US17227940

申请日：2021-04-12

Applicant: UNIVERSITY OF MANITOBA

Inventor： Song Liu ,  Sarvesh Logsetty

IPC: A61K9/70 ,  D01D5/00 ,  A61L15/24 ,  A61P17/02 ,  A61P31/04 ,  A61F13/00 ,  A61L15/26 ,  A61K47/32 ,  A61K47/34 ,  A61K9/00 ,  A61L15/46 ,  D01F1/10 ,  D01F8/14 ,  D01F8/10 ,  B82Y30/00

CPC classification number: A61K9/7007 ,  A61F13/00017 ,  A61K9/0092 ,  A61K9/703 ,  A61K47/32 ,  A61K47/34 ,  A61L15/24 ,  A61L15/26 ,  A61L15/46 ,  A61P17/02 ,  A61P31/04 ,  D01D5/0007 ,  D01F1/103 ,  D01F8/10 ,  D01F8/14 ,  A61F2013/00089 ,  A61L2300/208 ,  A61L2300/404 ,  A61L2300/604 ,  A61L2400/12 ,  B82Y30/00 ,  A61L15/24 ,  C08L39/06 ,  A61L15/26 ,  C08L67/04

Abstract: Bacteria-responsive core-shell nanofibers and a process for the preparation thereof are described. The nanofibers release of an antibacterial agent in response to the presence of bacteria. The core of the nanofiber comprises a biocompatible polymer together with an antibacterial agent such as a quaternary ammonium compound, for example benzyl dimethyl tetradecyl ammonium chloride (BTAC). Surrounding the core is shell comprised of a bacterially degradable polymer, which is susceptible to break-down by bacterial enzymes such as lipase, or to acidic pH conditions. The shell may comprise, for example, polycaprolactone (PCL) and poly(ethylene succinate) (PES). The nanofibers may be incorporated into wound dressings.

公开(公告)号：US10973775B2

公开(公告)日：2021-04-13

申请号：US16138577

申请日：2018-09-21

Applicant: UNIVERSITY OF MANITOBA

Inventor： Song Liu ,  Sarvesh Logsetty

IPC: A61K9/70 ,  D01D5/00 ,  A61L15/24 ,  A61P17/02 ,  A61P31/04 ,  A61F13/00 ,  A61L15/26 ,  A61K47/32 ,  A61K47/34 ,  A61K9/00 ,  A61L15/46 ,  D01F1/10 ,  D01F8/14 ,  D01F8/10 ,  B82Y30/00

Abstract: Bacteria-responsive core-shell nanofibers and a process for the preparation thereof are described. The nanofibers release of an antibacterial agent in response to the presence of bacteria. The core of the nanofiber comprises a biocompatible polymer together with an antibacterial agent such as a quaternary ammonium compound, for example benzyl dimethyl tetradecyl ammonium chloride (BTAC). Surrounding the core is shell comprised of a bacterially degradable polymer, which is susceptible to break-down by bacterial enzymes such as lipase, or to acidic pH conditions. The shell may comprise, for example, polycaprolactone (PCL) and poly(ethylene succinate) (PES). The nanofibers may be incorporated into wound dressings.