公开(公告)号：US20160122268A1

公开(公告)日：2016-05-05

申请号：US14891496

申请日：2014-05-16

Applicant: UNIVERSITY OF MARYLAND, COLLEGE PARK

Inventor： Frederick KHACHIK

IPC: C07C29/84 ,  B01D9/00 ,  B01D11/02

CPC classification number: C07C29/84 ,  A23L5/44 ,  A23V2002/00 ,  A61K2236/00 ,  B01D9/00 ,  B01D11/0219 ,  B01D11/0296 ,  B01D2009/0086 ,  A23V2250/211

Abstract: The present invention is in the field of organic and natural product chemistry. The present invention relates to an efficient process for purification, simultaneous extraction, and separation of monohydroxycarotenoids from dihydroxycarotenoids in various natural products or in synthetic mixtures. Similarly, the process can also be applied to the simultaneous extraction, saponification, and separation of esterified mono- and dihydroxycarotenoids in natural products and their oleoresins or in their synthetic mixtures. Therefore, esterified and unesterified monohydroxycarotenoids such as (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin can be efficiently separated from their corresponding dihydroxycarotenoids such as (3R,3′R,6′R)-lutein and (3R,3′R)-zeaxanthin that are found in various plants or in synthetic mixtures.

Abstract translation: 本发明在有机和天然产物化学领域。 本发明涉及从各种天然产物或合成混合物中的二羟基类胡萝卜素提纯，同时提取和分离单羟基类胡萝卜素的有效方法。 类似地，该方法也可以应用于天然产物及其油树脂或其合成混合物中酯化的单和二羟基类胡萝卜素的同时提取，皂化和分离。 因此，酯化和未酯化的单羟基类胡萝卜素如（3R） - 和 - 隐黄质和（3R，6'R）-α-隐黄质可以有效地从相应的二羟基类胡萝卜素中分离出来，如（3R，3'R，6'R） - 在各种植物或合成混合物中发现的叶黄素和（3R，3'R） - 次黄豆素。

公开(公告)号：US20160115122A1

公开(公告)日：2016-04-28

申请号：US14891499

申请日：2014-05-16

Applicant: UNIVERSITY OF MARYLAND, COLLEGE PARK

Inventor： Frederick KHACHIK

IPC: C07C403/24

CPC classification number: C07C403/24 ,  C07C2601/16

Abstract: The present invention relates to a process for converting commercially available lutein and/or lutein esters from extracts of marigold flower petals to (3R)-β-cryptoxanthin (major) and (3R,6′R)-α-cryptoxanthin (minor) in ratios ranging from 95:5 to 98:2 in a one-pot reaction at room temperature. Because the entire process can be carried out by employing safe and environmentally friendly food-grade reagents, the resulting mixture of these carotenoids is suitable for human consumption as a dietary supplement.

Abstract translation: 本发明涉及将市售的叶黄素和/或叶黄素酯从万寿菊花瓣提取物转化为（3R） - 重金黄素（主要）和（3R，6'R）-α-隐黄质（小） 在室温下的一锅反应中的比例为95:5至98:2。 因为整个过程可以通过使用安全和环保的食品级试剂进行，所得到的这些类胡萝卜素的混合物适合人类作为膳食补充剂使用。