公开(公告)号：US12178571B2

公开(公告)日：2024-12-31

申请号：US17333161

申请日：2021-05-28

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Boris P. Kovatchev ,  Marc D. Breton ,  Stephen D. Patek

IPC: A61B5/145 ,  A61B5/00 ,  A61M5/172 ,  G16H20/17 ,  G16H40/63 ,  G16H40/67 ,  G16H50/50

Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.

公开(公告)号：US11986294B2

公开(公告)日：2024-05-21

申请号：US18325564

申请日：2023-05-30

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Boris P. Kovatchev ,  Marc D. Breton ,  Stephen D. Patek

IPC: A61B5/145 ,  A61B5/00 ,  A61M5/172 ,  G16H20/17 ,  G16H40/63 ,  G16H50/50 ,  G16H40/67

CPC classification number: A61B5/14532 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/4839 ,  A61B5/7275 ,  A61B5/746 ,  A61M5/1723 ,  G16H20/17 ,  G16H40/63 ,  G16H50/50 ,  G16H40/67

Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.

公开(公告)号：US11751779B2

公开(公告)日：2023-09-12

申请号：US18069551

申请日：2022-12-21

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Boris P. Kovatchev ,  Marc D. Breton ,  Stephen D. Patek

IPC: A61M31/00 ,  A61B5/145 ,  G16H50/50 ,  A61B5/00 ,  G16H20/17 ,  A61M5/172 ,  G16H40/63 ,  G16H40/67

CPC classification number: A61B5/14532 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/4839 ,  A61B5/7275 ,  A61B5/746 ,  A61M5/1723 ,  G16H20/17 ,  G16H40/63 ,  G16H50/50 ,  G16H40/67

Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.

公开(公告)号：US11309088B2

公开(公告)日：2022-04-19

申请号：US16073920

申请日：2017-01-30

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Stephen D. Patek ,  Marc D. Breton

IPC: G16H50/50 ,  G16H50/70 ,  G16H10/60 ,  G16H40/63

Abstract: A method and system use mathematical models and available patient information to virtualize a continuous glucose monitoring trace for a period of time. Such a method and system can generate the virtualized trace when episodic patient data is incomplete. Such a method and system can also rely on self-monitored blood glucose measurement information to improve the virtualized continuous glucose monitoring trace.

公开(公告)号：US11179517B2

公开(公告)日：2021-11-23

申请号：US16483487

申请日：2018-02-05

Applicant: University of Virginia Patent Foundation

Inventor： Stephen D. Patek ,  Marc D. Breton

IPC: A61M5/172 ,  G16H20/17 ,  G16H40/67 ,  G16H10/60 ,  A61B5/145 ,  A61M5/142 ,  A61K38/28

Abstract: Equivalent insulin pump retrospective virtual basal rates for daily injections are constructed from planned insulin injections according to a virtual basal rate profile developed for a patient, and a database of historical insulin injections, i.e. basal injections actually administered by the patient, providing a unified framework for analysis, design, optimization, and adaptation of MDI (multiple daily injections) and CSII (continuous subcutaneous insulin infusion (i.e. insulin pump)) treatment parameters for patients with diabetes.

公开(公告)号：US12017045B2

公开(公告)日：2024-06-25

申请号：US17502346

申请日：2021-10-15

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Stephen D. Patek ,  Marc D. Breton

IPC: A61M5/172 ,  A61B5/145 ,  A61M5/142 ,  G16H10/60 ,  G16H20/17 ,  G16H40/67 ,  A61K38/28

CPC classification number: A61M5/1723 ,  A61B5/14532 ,  A61M5/14244 ,  G16H10/60 ,  G16H20/17 ,  G16H40/67 ,  A61K38/28 ,  A61M2205/3303 ,  A61M2205/3584 ,  A61M2205/502 ,  A61M2205/52

Abstract: Equivalent insulin pump retrospective virtual basal rates for daily injections are constructed from planned insulin injections according to a virtual basal rate profile developed for a patient, and a database of historical insulin injections, i.e. basal injections actually administered by the patient, providing a unified framework for analysis, design, optimization, and adaptation of MDI (multiple daily injections) and CSII (continuous subcutaneous insulin infusion (i.e. insulin pump)) treatment parameters for patients with diabetes.

公开(公告)号：US20200214629A1

公开(公告)日：2020-07-09

申请号：US16789901

申请日：2020-02-13

Applicant: University of Virginia Patent Foundation

Inventor： Boris P. Kovatchev ,  Patrick T. Keith-Hynes ,  Marc D. Breton ,  Stephen D. Patek

IPC: A61B5/00 ,  G16H50/20 ,  G16H50/30 ,  A61M5/172 ,  A61M5/168 ,  A61K38/28 ,  A61B5/11 ,  A61B5/0402 ,  A61B5/021 ,  A61B5/0205 ,  A61B5/145

Abstract: A flexible system for utilizing data from different monitoring techniques and capable of providing assistance to patients with diabetes at several scalable levels, ranging from advice about long-term trends and prognosis to real-time automated closed-loop control (artificial pancreas). These scalable monitoring and treatment strategies are delivered by a unified system called the Diabetes Assistant (DiAs) platform. The system provides a foundation for implementation of various monitoring, advisory, and automated diabetes treatment algorithms or methods. The DiAs recommendations are tailored to the specifics of an individual patient, and to the patient risk assessment at any given moment.

公开(公告)号：US20180279914A1

公开(公告)日：2018-10-04

申请号：US15764063

申请日：2016-09-28

Applicant: University of Virginia Patent Foundation

Inventor： Stephen D. Patek ,  Matthew M. Engelhard ,  John Lach ,  Myla D. Goldman

IPC: A61B5/11 ,  G06K9/00 ,  G06K9/62

Abstract: A gait pathology detection and monitoring system, and method using rotation, scale, and offset invariant dynamic time warping (RSOI-DTW).

公开(公告)号：US20150193589A1

公开(公告)日：2015-07-09

申请号：US14419375

申请日：2013-08-05

Applicant: University of Virginia Patent Foundation

Inventor： Edward A. Ortiz ,  Stephen D. Patek ,  Marc D. Breton ,  Leon S. Farhi ,  Boris P. Kovatchev

IPC: G06F19/00

CPC classification number: G16H50/50 ,  C12Q1/54

Abstract: Time-varying hyperglycemic stresses are derived from actual ICU patients and applied to non-critically ill virtual patients, using any model of normal glucose-insulin physiology that fulfills certain requirements, in order to model and simulate stress hyperglycemia. Other aspects provide: 1) a methodology to perform sensitivity analyses of the parameters of ICU insulin infusion therapy protocols and to improve the protocols; and 2) a training system for clinicians about the course and management of stress hyperglycemia in the ICU or other facility.

Abstract translation: 随时间变化的高血糖应激来自实际的ICU患者，并应用于非危重症虚拟患者，使用任何符合某些要求的正常葡萄糖 - 胰岛素生理模型，以模拟和模拟应激性高血糖。 其他方面提供：1）对ICU胰岛素输注治疗方案参数进行灵敏度分析的方法，并改进方案; 和2）临床医生关于ICU或其他设施中压力高血糖过程和管理的培训系统。

公开(公告)号：US12266436B2

公开(公告)日：2025-04-01

申请号：US17339153

申请日：2021-06-04

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Marc D. Breton ,  Stephen D. Patek ,  Boris P. Kovatchev ,  Colleen H. Karvetski

IPC: G16H20/17 ,  A61M5/168 ,  G01N33/74

Abstract: An insulin delivery supervisor (IDS) with a safety analysis and supervision function that can reside between the insulin request and the insulin delivery and can intercept any excessive insulin requests before the insulin was delivered. The IDS can be implemented in any system based on insulin pump or pen and will work with either SMBG or CGM modes of blood glucose monitoring.