公开(公告)号：US20170166519A1

公开(公告)日：2017-06-15

申请号：US15124748

申请日：2015-03-12

Applicant: UNIVERSITY OF WARWICK

Inventor： Andrew EASTON ,  Phillip GOULD ,  Andrew MARSH

IPC: C07C275/30 ,  C07C275/40 ,  C07C323/44 ,  G01N33/53 ,  C07C317/42 ,  C07D239/42 ,  C07D295/16 ,  G01N33/573 ,  C07C275/42 ,  C07D213/75

CPC classification number: C07C275/30 ,  A61K31/17 ,  A61K31/4402 ,  A61K31/505 ,  A61K31/5375 ,  C07C275/34 ,  C07C275/40 ,  C07C275/42 ,  C07C317/42 ,  C07C323/36 ,  C07C323/44 ,  C07C335/16 ,  C07C2601/14 ,  C07D213/72 ,  C07D213/75 ,  C07D239/42 ,  C07D295/16 ,  C12Q1/18 ,  C12Y306/04013 ,  G01N33/5308 ,  G01N33/56983 ,  G01N33/573 ,  G01N2333/135 ,  G01N2333/914 ,  G01N2500/02

Abstract: The invention relates to a DDX3X inhibitorfor use in the treatment of pneumovirus infection in a mammal, wherein the DDX3X inhibitor may be a compound of Formula (I) wherein y, Z, R1, X, L, Ra and Rb are as defined herein. The invention also relates to compounds of Formula (I).