公开(公告)号：US20240401108A1

公开(公告)日：2024-12-05

申请号：US18649007

申请日：2024-04-29

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Scott R. Kennedy ,  Jesse J. Salk ,  Michael Hipp ,  Elizabeth Schmidt ,  Rosa Ana Risques ,  Daniela Nachmanson

IPC: C12Q1/6806 ,  C12Q1/6855 ,  C12Q1/686

Abstract: The present technology relates generally to methods and compositions for targeted nucleic acid sequence enrichment, as well as uses of such enrichment for error-corrected nucleic acid sequencing applications. In some embodiments, highly accurate, error corrected and massively parallel sequencing of nucleic acid material is possible using a combination of uniquely labeled strands in a double-stranded nucleic acid complex in such a way that each strand can be informatically related to its complementary strand, but also distinguished from it following sequencing of each strand or an amplified product derived therefrom. In various embodiments, this information can be used for the purpose of error correction of the determined sequence.

公开(公告)号：US12006532B2

公开(公告)日：2024-06-11

申请号：US17933058

申请日：2022-09-16

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Scott R. Kennedy ,  Jesse J. Salk ,  Michael Hipp ,  Elizabeth Schmidt ,  Rosa Ana Risques ,  Daniela Nachmanson

IPC: C12Q1/6806 ,  C12Q1/6855 ,  C12Q1/686

CPC classification number: C12Q1/6806 ,  C12Q1/6855 ,  C12Q1/686 ,  C12Q2521/501 ,  C12Q2525/191 ,  C12Q2531/113 ,  C12Q2535/119 ,  C12Q2535/122

Abstract: The present technology relates generally to methods and compositions for targeted nucleic acid sequence enrichment, as well as uses of such enrichment for error-corrected nucleic acid sequencing applications. In some embodiments, highly accurate, error corrected and massively parallel sequencing of nucleic acid material is possible using a combination of uniquely labeled strands in a double-stranded nucleic acid complex in such a way that each strand can be informatically related to its complementary strand, but also distinguished from it following sequencing of each strand or an amplified product derived therefrom. In various embodiments, this information can be used for the purpose of error correction of the determined sequence.

公开(公告)号：US11479807B2

公开(公告)日：2022-10-25

申请号：US16496936

申请日：2018-03-23

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Scott R. Kennedy ,  Jesse J. Salk ,  Michael Hipp ,  Elizabeth Schmidt ,  Rosa Ana Risques ,  Daniela Nachmanson

IPC: C12Q1/6806 ,  C12Q1/6855 ,  C12Q1/686

Abstract: The present technology relates generally to methods and compositions for targeted nucleic acid sequence enrichment, as well as uses of such enrichment for error-corrected nucleic acid sequencing applications. In some embodiments, highly accurate, error corrected and massively parallel sequencing of nucleic acid material is possible using a combination of uniquely labeled strands in a double-stranded nucleic acid complex in such a way that each strand can be informatically related to its complementary strand, but also distinguished from it following sequencing of each strand or an amplified product derived therefrom. In various embodiments, this information can be used for the purpose of error correction of the determined sequence.

公开(公告)号：US20230295686A1

公开(公告)日：2023-09-21

申请号：US17933058

申请日：2022-09-16

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Scott R. Kennedy ,  Jesse J. Salk ,  Michael Hipp ,  Elizabeth Schmidt ,  Rosa Ana Risques ,  Daniela Nachmanson

IPC: C12Q1/6806 ,  C12Q1/6855 ,  C12Q1/686

CPC classification number: C12Q1/6806 ,  C12Q1/6855 ,  C12Q1/686 ,  C12Q2521/501 ,  C12Q2525/191 ,  C12Q2531/113 ,  C12Q2535/119 ,  C12Q2535/122

Abstract: The present technology relates generally to methods and compositions for targeted nucleic acid sequence enrichment, as well as uses of such enrichment for error-corrected nucleic acid sequencing applications. In some embodiments, highly accurate, error corrected and massively parallel sequencing of nucleic acid material is possible using a combination of uniquely labeled strands in a double-stranded nucleic acid complex in such a way that each strand can be informatically related to its complementary strand, but also distinguished from it following sequencing of each strand or an amplified product derived therefrom. In various embodiments, this information can be used for the purpose of error correction of the determined sequence.