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    Immunogenic compositions, antigen screening methods, and methods of generating immune responses
    1.
    发明授权
    Immunogenic compositions, antigen screening methods, and methods of generating immune responses 有权

    公开(公告)号：US12233117B2

    公开(公告)日：2025-02-25

    申请号：US18359740

    申请日：2023-07-26

    Applicant: UNIVERSITY OF WASHINGTON

    Inventor： Sean C. Murphy ,  Bradley C. Stone

    IPC: A61K39/015 ,  A61K45/06 ,  A61K47/69 ,  A61P33/06 ,  C07K14/15 ,  A61K39/00

    Abstract: An immunogenic composition is provided herein. The immunogenic compositions are used to identify and select immunogenic antigens that elicit immune responses in a subject and may be subsequently used in multi-antigen vaccine compositions against one or more diseases or conditions. According to some embodiments, the immunogenic composition may include a plurality of nucleic acid fragments or minigenes derived from a nucleic acid library, wherein each nucleic acid fragment encodes a different antigen or functional portion thereof, and wherein the different antigens or functional portions thereof are associated with one or more disease or condition. The immunogenic composition may also include a delivery medium loaded with the plurality of nucleic acid fragments and in some embodiments, the delivery medium is loaded with nucleic acid fragments in such a way that individual antigen presenting cells receive only a subset of the nucleic acids within a vaccine in order to minimize antigenic competition.

    Immunogenic compositions, antigen screening methods, and methods of generating immune responses
    2.
    发明授权
    Immunogenic compositions, antigen screening methods, and methods of generating immune responses 有权

    公开(公告)号：US10925950B2

    公开(公告)日：2021-02-23

    申请号：US15749928

    申请日：2016-08-03

    Applicant: UNIVERSITY OF WASHINGTON

    Inventor： Sean C. Murphy ,  Brad Stone

    IPC: A61K48/00 ,  A61K39/015 ,  A61K47/69 ,  A61P33/06 ,  A61K45/06 ,  C07K14/15 ,  A61K39/00

    Abstract: An immunogenic composition is provided herein. The immunogenic compositions are used to identify and select immunogenic antigens that elicit immune responses in a subject and may be subsequently used in multi-antigen vaccine compositions against one or more diseases or conditions. According to some embodiments, the immunogenic composition may include a plurality of nucleic acid fragments or minigenes derived from a nucleic acid library, wherein each nucleic acid fragment encodes a different antigen or functional portion thereof, and wherein the different antigens or functional portions thereof are associated with one or more disease or condition. The immunogenic composition may also include a delivery medium loaded with the plurality of nucleic acid fragments and in some embodiments, the delivery medium is loaded with nucleic acid fragments in such a way that individual antigen presenting cells receive only a subset of the nucleic acids within a vaccine in order to minimize antigenic competition.

    Targeted vaccination in the liver
    4.
    发明授权
    Targeted vaccination in the liver 有权

    公开(公告)号：US12144853B2

    公开(公告)日：2024-11-19

    申请号：US17147438

    申请日：2021-01-12

    Applicant: UNIVERSITY OF WASHINGTON

    Inventor： Sean C. Murphy ,  Bradley C. Stone

    IPC: A61K39/015 ,  A61K39/00 ,  A61P33/06 ,  C07K14/445

    Abstract: In one aspect, the present disclosure provides a trapping vaccine composition comprising a trapping antigenic component, a protective component, and a liver cell-targeting component, wherein the trapping antigenic component comprises a nucleic acid molecule or a protein, the protective component comprises a synthetic or non-natural molecule or formation of synthetic or non-natural molecules, and wherein the liver cell-targeting component is capable of delivering the vaccine composition to a liver cell or liver tissue. The present disclosure additional provides vaccination methods comprising (i) administering a priming composition comprising a priming antigenic component or a first dose comprising the priming composition to the mammal; and (ii) administering a trapping composition comprising a trapping antigenic component, a protective component, and a liver cell-targeting component, or a second dose comprising the second composition to the mammal, wherein the priming and trapping compositions or doses are not administered concurrently and wherein the number of resident memory T cells in the liver are increased following administration of the trapping composition. In certain embodiments, vaccine compositions and regimes are provided that protect against liver-tropic pathogens, e.g., a malarial infection. In an embodiment, a vaccine composition and regimen are provided that protect against an infection caused by P. falciparum or P. yoelli sporozoites.

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