公开(公告)号：US11771755B2

公开(公告)日：2023-10-03

申请号：US16971278

申请日：2019-02-28

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Neil King ,  David Baker ,  Lance Stewart ,  Brooke Fiala ,  Daniel Ellis ,  Lauren Carter ,  Rashmi Ravichandran ,  George Ueda ,  Jorge Fallas ,  Una Nattermann

IPC: A61K39/12 ,  C12N15/86 ,  B82Y5/00 ,  B82Y40/00

CPC classification number: A61K39/12 ,  C12N15/86 ,  B82Y5/00 ,  B82Y40/00 ,  C12N2710/16134 ,  C12N2710/16234 ,  C12N2760/00034

Abstract: Nanostructures and nanostructure-based vaccines that display antigens capable of eliciting immune responses to infectious agents such as bacteria, viruses, and pathogens are provided. Some vaccines are useful for preventing or decreasing the severity of infection with an infectious agent, including, for example and without limitation, lyme disease, pertussis, herpes virus, orthomyxovirus, paramyxovirus, pneumovirus, filovirus, flavivirus, reovirus, retrovirus, meningococcus, or malaria. The antigens may be attached to the core of the nanostructure either non-covalently or covalently, including as a fusion protein or by other means. Multimeric antigens may optionally be displayed along a symmetry axis of the nanostructure. Also provided are proteins and nucleic acid molecules encoding such proteins, vaccine compositions, and methods of administration.

公开(公告)号：US20230075095A1

公开(公告)日：2023-03-09

申请号：US17760180

申请日：2021-02-12

Applicant: University of Washington

Inventor： Neil P. KING ,  Carl Walkey ,  Jing Yang Wang ,  Brooke Fiala ,  David Veesler ,  Alexandra C. Walls ,  Una Nattermann

IPC: C07K14/005 ,  C12N15/63 ,  G16B20/50

Abstract: Polypeptides are disclosed herein having significantly improved secretion ability from eukaryotic cells, together with fusion proteins, nanoparticles, and uses thereof, and methods for designing such polypeptides.